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Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes

Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes
Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes

Background: Chewing imbalances are associated with neurodegeneration and are risk factors for senile dementia in humans and memory deficits in experimental animals. We investigated the impact of long-term reduced mastication on spatial memory in young, mature and aged female albino Swiss mice by stereological analysis of the laminar distribution of CA1 astrocytes. A soft diet (SD) was used to reduce mastication in the experimental group, whereas the control group was fed a hard diet (HD). Assays were performed in 3-, 6- and 18-month-old SD and HD mice.Results: Eating a SD variably affected the number of astrocytes in the CA1 hippocampal field, and SD mice performed worse on water maze memory tests than HD mice. Three-month-old mice in both groups could remember/find a hidden platform in the water maze. However, 6-month-old SD mice, but not HD mice, exhibited significant spatial memory dysfunction. Both SD and HD 18-month-old mice showed spatial memory decline. Older SD mice had astrocyte hyperplasia in the strata pyramidale and oriens compared to 6-month-old mice. Aging induced astrocyte hypoplasia at 18 months in the lacunosum-moleculare layer of HD mice.Conclusions: Taken together, these results suggest that the impaired spatial learning and memory induced by masticatory deprivation and aging may be associated with altered astrocyte laminar distribution and number in the CA1 hippocampal field. The underlying molecular mechanisms are unknown and merit further investigation.

1471-2202
Frota de Almeida, Marina N.
5946d1c0-19ef-4723-bd6c-d5e17ad8fa5c
de Siqueira Mendes, Fabíola D.C.C.
c6abe207-7b1f-458c-85e1-5d48ee712774
Gurgel Felício, André P.
eea698c1-9e31-4049-b5d9-c9dd2c59cc2d
Falsoni, Manoela
5cadcf04-cdf5-4ebb-a681-9aa379eea8c1
Ferreira de Andrade, Márcia L.
f02715c0-1088-4fbb-8a68-578b7402dec9
Bento-Torres, João
1a8c0126-eee8-4a32-9bda-5faae754dc3e
da Costa Vasconcelos, Pedro F.
4c996ece-f6f8-430c-a6be-5576f814d2e5
Perry, Victor H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Picanço-Diniz, Cristovam W.
014f722f-9f1f-498f-acc3-7ab499783417
Kronka Sosthenes, Marcia C.
ff7bf3e5-5d83-4a7a-9143-9a3769fc932b
Frota de Almeida, Marina N.
5946d1c0-19ef-4723-bd6c-d5e17ad8fa5c
de Siqueira Mendes, Fabíola D.C.C.
c6abe207-7b1f-458c-85e1-5d48ee712774
Gurgel Felício, André P.
eea698c1-9e31-4049-b5d9-c9dd2c59cc2d
Falsoni, Manoela
5cadcf04-cdf5-4ebb-a681-9aa379eea8c1
Ferreira de Andrade, Márcia L.
f02715c0-1088-4fbb-8a68-578b7402dec9
Bento-Torres, João
1a8c0126-eee8-4a32-9bda-5faae754dc3e
da Costa Vasconcelos, Pedro F.
4c996ece-f6f8-430c-a6be-5576f814d2e5
Perry, Victor H.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Picanço-Diniz, Cristovam W.
014f722f-9f1f-498f-acc3-7ab499783417
Kronka Sosthenes, Marcia C.
ff7bf3e5-5d83-4a7a-9143-9a3769fc932b

Frota de Almeida, Marina N., de Siqueira Mendes, Fabíola D.C.C., Gurgel Felício, André P., Falsoni, Manoela, Ferreira de Andrade, Márcia L., Bento-Torres, João, da Costa Vasconcelos, Pedro F., Perry, Victor H., Picanço-Diniz, Cristovam W. and Kronka Sosthenes, Marcia C. (2012) Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes. BMC Neuroscience, 13 (1), [23]. (doi:10.1186/1471-2202-13-23).

Record type: Article

Abstract

Background: Chewing imbalances are associated with neurodegeneration and are risk factors for senile dementia in humans and memory deficits in experimental animals. We investigated the impact of long-term reduced mastication on spatial memory in young, mature and aged female albino Swiss mice by stereological analysis of the laminar distribution of CA1 astrocytes. A soft diet (SD) was used to reduce mastication in the experimental group, whereas the control group was fed a hard diet (HD). Assays were performed in 3-, 6- and 18-month-old SD and HD mice.Results: Eating a SD variably affected the number of astrocytes in the CA1 hippocampal field, and SD mice performed worse on water maze memory tests than HD mice. Three-month-old mice in both groups could remember/find a hidden platform in the water maze. However, 6-month-old SD mice, but not HD mice, exhibited significant spatial memory dysfunction. Both SD and HD 18-month-old mice showed spatial memory decline. Older SD mice had astrocyte hyperplasia in the strata pyramidale and oriens compared to 6-month-old mice. Aging induced astrocyte hypoplasia at 18 months in the lacunosum-moleculare layer of HD mice.Conclusions: Taken together, these results suggest that the impaired spatial learning and memory induced by masticatory deprivation and aging may be associated with altered astrocyte laminar distribution and number in the CA1 hippocampal field. The underlying molecular mechanisms are unknown and merit further investigation.

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More information

Published date: 29 February 2012
Additional Information: Funding Information: This project was supported by research funds from the Brazilian Government. MCKS was supported by a grant from the Brazilian Research Council CNPq (grant number 475677/2008-0) and from FAPESPA - Fundação de Amparo à Pesquisa do Estado do Pará (grant number 136/08). Research funds from Fundação de Amparo e Desenvolvimento da Pesquisa – FADESP and Pró-Reitoria de Pesquisa e Pós-Graduação – PROPESP/UFPA covered proofreading, edition and publication fees.

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Local EPrints ID: 479180
URI: http://eprints.soton.ac.uk/id/eprint/479180
ISSN: 1471-2202
PURE UUID: e98daf3f-d7dd-44d2-8663-ed09f24869c1

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Date deposited: 20 Jul 2023 16:43
Last modified: 05 Jun 2024 20:04

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Contributors

Author: Marina N. Frota de Almeida
Author: Fabíola D.C.C. de Siqueira Mendes
Author: André P. Gurgel Felício
Author: Manoela Falsoni
Author: Márcia L. Ferreira de Andrade
Author: João Bento-Torres
Author: Pedro F. da Costa Vasconcelos
Author: Victor H. Perry
Author: Cristovam W. Picanço-Diniz
Author: Marcia C. Kronka Sosthenes

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