A metapopulation model of granuloma formation in the lung during infection with Mycobacterium tuberculosis
A metapopulation model of granuloma formation in the lung during infection with Mycobacterium tuberculosis
The immune response to Mycobacterium tuberculosis infection (Mtb) is the formation of unique lesions, called granulomas. How well these granulomas form and function is a key issue that might explain why individuals experience different disease outcomes. The spatial structures of these granulomas are not well understood. In this paper, we use a metapopulation framework to develop a spatio-temporal model of the immune response to Mtb. Using this model, we are able to investigate the spatial organization of the immune response in the lungs to Mtb. We identify both host and pathogen factors that contribute to successful infection control. Additionally, we identify specific spatial interactions and mechanisms important for successful granuloma formation. These results can be further studied in the experimental setting.
Mycobacterium tuberculosis, granuloma, mathematical model, metapopulation, chemotaxis, diffusion
535-560
Ganguli, S
800e7eac-87e8-437d-bafd-bcf59fc15ae6
Gammack, D
65b60f25-7546-4132-99da-e140f4727f8d
Kirschner, DE
d0e52b50-4e5f-4b34-ae70-f8d9e89bbd9d
1 August 2005
Ganguli, S
800e7eac-87e8-437d-bafd-bcf59fc15ae6
Gammack, D
65b60f25-7546-4132-99da-e140f4727f8d
Kirschner, DE
d0e52b50-4e5f-4b34-ae70-f8d9e89bbd9d
Ganguli, S, Gammack, D and Kirschner, DE
(2005)
A metapopulation model of granuloma formation in the lung during infection with Mycobacterium tuberculosis.
MATHEMATICAL BIOSCIENCES AND ENGINEERING, 2 (3), .
(doi:10.3934/mbe.2005.2.535).
Abstract
The immune response to Mycobacterium tuberculosis infection (Mtb) is the formation of unique lesions, called granulomas. How well these granulomas form and function is a key issue that might explain why individuals experience different disease outcomes. The spatial structures of these granulomas are not well understood. In this paper, we use a metapopulation framework to develop a spatio-temporal model of the immune response to Mtb. Using this model, we are able to investigate the spatial organization of the immune response in the lungs to Mtb. We identify both host and pathogen factors that contribute to successful infection control. Additionally, we identify specific spatial interactions and mechanisms important for successful granuloma formation. These results can be further studied in the experimental setting.
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Published date: 1 August 2005
Keywords:
Mycobacterium tuberculosis, granuloma, mathematical model, metapopulation, chemotaxis, diffusion
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Local EPrints ID: 479234
URI: http://eprints.soton.ac.uk/id/eprint/479234
ISSN: 1547-1063
PURE UUID: ccef879c-9634-4e7b-af77-20f04129f0f6
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Date deposited: 20 Jul 2023 16:47
Last modified: 17 Mar 2024 03:33
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Contributors
Author:
S Ganguli
Author:
DE Kirschner
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