PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis
Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
Adenosine Triphosphate/metabolism Animals Binding Sites Cell Line, Transformed Cell Proliferation Cell Transformation, Neoplastic/genetics/*metabolism/pathology Fibroblasts/metabolism/pathology *Gene Expression Regulation, Neoplastic Guanosine Triphosphate/*metabolism Humans Isoenzymes/genetics/metabolism Kinetics Mice Mice, Nude Mutation Phosphatidylinositol Phosphates/*metabolism Phosphotransferases (Alcohol Group Acceptor)/*genetics/metabolism Protein Binding Signal Transduction
473-475
Fiume, R.
ed01a587-2ca6-480d-baa3-cc221a6830ae
Jones, D. R.
fcbc07f0-6ce7-4ea0-b8b3-f0e6a9581279
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
1 June 2016
Fiume, R.
ed01a587-2ca6-480d-baa3-cc221a6830ae
Jones, D. R.
fcbc07f0-6ce7-4ea0-b8b3-f0e6a9581279
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Fiume, R., Jones, D. R. and Divecha, N.
(2016)
PIP4K2B: Coupling GTP Sensing to PtdIns5P Levels to Regulate Tumorigenesis.
Trends in Biochemical Sciences, 41 (6), .
(doi:10.1016/j.tibs.2016.04.003).
Abstract
Although guanine nucleotides are essential for cell growth, how their levels are sensed in mammalian cells is unknown. Sumita et al. show that PIP4K2B, a phosphoinositide kinase, is a molecular sensor that transduces changes in GTP into changes in the levels of the phosphoinositide PtdIns5P to modulate tumour cell growth.
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Published date: 1 June 2016
Additional Information:
Fiume, Roberta Jones, David R Divecha, Nullin eng Comment Research Support, Non-U.S. Gov't England 2016/05/03 Trends Biochem Sci. 2016 Jun;41(6):473-475. doi: 10.1016/j.tibs.2016.04.003. Epub 2016 Apr 28.
Keywords:
Adenosine Triphosphate/metabolism Animals Binding Sites Cell Line, Transformed Cell Proliferation Cell Transformation, Neoplastic/genetics/*metabolism/pathology Fibroblasts/metabolism/pathology *Gene Expression Regulation, Neoplastic Guanosine Triphosphate/*metabolism Humans Isoenzymes/genetics/metabolism Kinetics Mice Mice, Nude Mutation Phosphatidylinositol Phosphates/*metabolism Phosphotransferases (Alcohol Group Acceptor)/*genetics/metabolism Protein Binding Signal Transduction
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Local EPrints ID: 479363
URI: http://eprints.soton.ac.uk/id/eprint/479363
ISSN: 0968-0004
PURE UUID: 22f851fe-64d4-4924-85a7-43735917fa93
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Date deposited: 20 Jul 2023 17:34
Last modified: 17 Mar 2024 02:59
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Author:
R. Fiume
Author:
D. R. Jones
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