PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions
It has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P(2) acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P(2) production, and discuss the role of these proteins in different cellular processes.
Animals *Gene Expression Regulation, Enzymologic Humans Multigene Family Phosphatidylinositol 4,5-Diphosphate/*metabolism Phosphotransferases (Alcohol Group Acceptor)/*genetics/*metabolism
3837-3850
van den Bout, I.
529d3340-8aeb-4d79-bb38-807a7cef83cb
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
1 November 2009
van den Bout, I.
529d3340-8aeb-4d79-bb38-807a7cef83cb
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
van den Bout, I. and Divecha, N.
(2009)
PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.
Journal of Cell Science, 122 (21), .
(doi:10.1242/jcs.056127).
Abstract
It has long been known that phosphoinositides are present in cellular membranes, but only in the past four decades has our understanding of their importance for proper cell function advanced significantly. Key to determining the biological roles of phosphoinositides is understanding the enzymes involved in their metabolism. Although many such enzymes have now been identified, there is still much to learn about their cellular functions. Phosphatidylinositol 4-phosphate 5-kinases (PIP5Ks) are a group of kinases that catalyse the production of phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P(2)]. As well as being a substrate for the enzymes phospholipase C (PLC) and phosphatidylinositol 3-kinase (PI3K), PtdIns(4,5)P(2) acts as a second messenger in its own right, influencing a variety of cellular processes. In this Commentary, we review how PIP5Ks are modulated to achieve regulated PtdIns(4,5)P(2) production, and discuss the role of these proteins in different cellular processes.
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Published date: 1 November 2009
Additional Information:
van den Bout, Iman Divecha, Nullin eng Review England 2009/11/06 J Cell Sci. 2009 Nov 1;122(Pt 21):3837-50. doi: 10.1242/jcs.056127.
Keywords:
Animals *Gene Expression Regulation, Enzymologic Humans Multigene Family Phosphatidylinositol 4,5-Diphosphate/*metabolism Phosphotransferases (Alcohol Group Acceptor)/*genetics/*metabolism
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Local EPrints ID: 479392
URI: http://eprints.soton.ac.uk/id/eprint/479392
ISSN: 1477-9137
PURE UUID: b7015c93-bad7-495a-b54b-67e6dc80c3b5
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Date deposited: 20 Jul 2023 17:41
Last modified: 17 Mar 2024 03:00
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Author:
I. van den Bout
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