Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing
Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing
People with blood cancers have an increased risk of severe COVID-19 disease despite booster vaccine doses.1 This group, like other disease groups at increased risk of severe COVID-19, includes individuals with highly heterogeneous immune responses to vaccination.2 Although vaccine response studies and population studies identify similar diseases and treatments associated with increased risk of severe COVID-19, a direct correlation between antibody levels after vaccination and infection risk has been difficult to define. Identification of a laboratory correlate of infection risk would allow doctors and policy makers to target additional COVID-19 treatment or prophylactic efforts to people who are most in need.
99-102
Wijaya, Ratna
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Johnson, Marina
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Campbell, Nicola
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Stuart, Beth
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Kelly, Adam
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Tipler, Nicole
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Menne, Tobias
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Ahearne, Matthew J.
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Willimott, Victoria
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Bowzyk Al-Naeeb, Anna
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Fox, Christopher P.
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Fox, Graham P.
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Collins, Graham P.
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O'Callaghan, Ann
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Davies, Andrew J.
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Goldblatt, David
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Lim, Sean H.
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6 July 2023
Wijaya, Ratna
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Johnson, Marina
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Campbell, Nicola
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Stuart, Beth
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Kelly, Adam
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Tipler, Nicole
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Menne, Tobias
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Ahearne, Matthew J.
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Willimott, Victoria
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Bowzyk Al-Naeeb, Anna
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Fox, Christopher P.
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Fox, Graham P.
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Collins, Graham P.
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O'Callaghan, Ann
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Davies, Andrew J.
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Goldblatt, David
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Lim, Sean H.
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Wijaya, Ratna, Johnson, Marina, Campbell, Nicola, Stuart, Beth, Kelly, Adam, Tipler, Nicole, Menne, Tobias, Ahearne, Matthew J., Willimott, Victoria, Bowzyk Al-Naeeb, Anna, Fox, Christopher P., Fox, Graham P., Collins, Graham P., O'Callaghan, Ann, Davies, Andrew J., Goldblatt, David and Lim, Sean H.
,
PROSECO investigators
(2023)
Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing.
The Lancet, 402 (10396), .
(doi:10.1016/S0140-6736(23)01180-7).
Abstract
People with blood cancers have an increased risk of severe COVID-19 disease despite booster vaccine doses.1 This group, like other disease groups at increased risk of severe COVID-19, includes individuals with highly heterogeneous immune responses to vaccination.2 Although vaccine response studies and population studies identify similar diseases and treatments associated with increased risk of severe COVID-19, a direct correlation between antibody levels after vaccination and infection risk has been difficult to define. Identification of a laboratory correlate of infection risk would allow doctors and policy makers to target additional COVID-19 treatment or prophylactic efforts to people who are most in need.
Text
1-s2.0-S0140673623011807-main
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More information
e-pub ahead of print date: 29 June 2023
Published date: 6 July 2023
Identifiers
Local EPrints ID: 479434
URI: http://eprints.soton.ac.uk/id/eprint/479434
ISSN: 0140-6736
PURE UUID: 7268f118-deca-469a-bf18-add42d94b5bd
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Date deposited: 24 Jul 2023 16:43
Last modified: 16 Aug 2024 01:41
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Contributors
Author:
Ratna Wijaya
Author:
Marina Johnson
Author:
Nicola Campbell
Author:
Adam Kelly
Author:
Nicole Tipler
Author:
Tobias Menne
Author:
Matthew J. Ahearne
Author:
Victoria Willimott
Author:
Anna Bowzyk Al-Naeeb
Author:
Christopher P. Fox
Author:
Graham P. Fox
Author:
Graham P. Collins
Author:
Ann O'Callaghan
Author:
Andrew J. Davies
Author:
David Goldblatt
Corporate Author: PROSECO investigators
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