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Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing

Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing
Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing
People with blood cancers have an increased risk of severe COVID-19 disease despite booster vaccine doses.1 This group, like other disease groups at increased risk of severe COVID-19, includes individuals with highly heterogeneous immune responses to vaccination.2 Although vaccine response studies and population studies identify similar diseases and treatments associated with increased risk of severe COVID-19, a direct correlation between antibody levels after vaccination and infection risk has been difficult to define. Identification of a laboratory correlate of infection risk would allow doctors and policy makers to target additional COVID-19 treatment or prophylactic efforts to people who are most in need.
0140-6736
99-102
Wijaya, Ratna
03dbd605-74df-4a5b-ad44-d04f7b17f5f4
Johnson, Marina
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Campbell, Nicola
dc81f433-c6de-4f77-b057-0d3a7801cbce
Stuart, Beth
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Kelly, Adam
f1934867-f5b4-4894-9336-4f6f878206c2
Tipler, Nicole
26959e6c-3a73-441e-9c7d-dfc3264cd81f
Menne, Tobias
c6321e46-2fc2-456e-a7aa-b39104d08eb6
Ahearne, Matthew J.
ca39ce66-5e6e-47d9-b464-6e05250ad633
Willimott, Victoria
4889fc95-6610-423f-bfc9-8a9617f8fc32
Bowzyk Al-Naeeb, Anna
1c8e649e-b52c-4c2e-bf6c-67be469ed507
Fox, Christopher P.
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Fox, Graham P.
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Collins, Graham P.
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O'Callaghan, Ann
891da9cd-d65b-4292-b936-ae5c95830052
Davies, Andrew J.
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Goldblatt, David
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Lim, Sean H.
1afe5aa1-61a4-4a7b-927f-5e671f885196
PROSECO investigators
Wijaya, Ratna
03dbd605-74df-4a5b-ad44-d04f7b17f5f4
Johnson, Marina
5942281a-061e-4889-a809-31dbd3d9cb55
Campbell, Nicola
dc81f433-c6de-4f77-b057-0d3a7801cbce
Stuart, Beth
626862fc-892b-4f6d-9cbb-7a8d7172b209
Kelly, Adam
f1934867-f5b4-4894-9336-4f6f878206c2
Tipler, Nicole
26959e6c-3a73-441e-9c7d-dfc3264cd81f
Menne, Tobias
c6321e46-2fc2-456e-a7aa-b39104d08eb6
Ahearne, Matthew J.
ca39ce66-5e6e-47d9-b464-6e05250ad633
Willimott, Victoria
4889fc95-6610-423f-bfc9-8a9617f8fc32
Bowzyk Al-Naeeb, Anna
1c8e649e-b52c-4c2e-bf6c-67be469ed507
Fox, Christopher P.
9ddc7032-e310-491d-a1b9-85d724d0bb50
Fox, Graham P.
6a443388-1dff-4b46-8cf9-b4f6a409214f
Collins, Graham P.
383f579f-8748-4d35-9b60-74508fdcda90
O'Callaghan, Ann
891da9cd-d65b-4292-b936-ae5c95830052
Davies, Andrew J.
6289b5e8-da1b-4189-b7ff-ac6ecf147afb
Goldblatt, David
0710c826-5bbe-49eb-8e0d-635b5e1ad0e3
Lim, Sean H.
1afe5aa1-61a4-4a7b-927f-5e671f885196

Wijaya, Ratna, Johnson, Marina, Campbell, Nicola, Stuart, Beth, Kelly, Adam, Tipler, Nicole, Menne, Tobias, Ahearne, Matthew J., Willimott, Victoria, Bowzyk Al-Naeeb, Anna, Fox, Christopher P., Fox, Graham P., Collins, Graham P., O'Callaghan, Ann, Davies, Andrew J., Goldblatt, David and Lim, Sean H. , PROSECO investigators (2023) Predicting COVID-19 infection risk in people who are immunocompromised by antibody testing. The Lancet, 402 (10396), 99-102. (doi:10.1016/S0140-6736(23)01180-7).

Record type: Letter

Abstract

People with blood cancers have an increased risk of severe COVID-19 disease despite booster vaccine doses.1 This group, like other disease groups at increased risk of severe COVID-19, includes individuals with highly heterogeneous immune responses to vaccination.2 Although vaccine response studies and population studies identify similar diseases and treatments associated with increased risk of severe COVID-19, a direct correlation between antibody levels after vaccination and infection risk has been difficult to define. Identification of a laboratory correlate of infection risk would allow doctors and policy makers to target additional COVID-19 treatment or prophylactic efforts to people who are most in need.

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e-pub ahead of print date: 29 June 2023
Published date: 6 July 2023

Identifiers

Local EPrints ID: 479434
URI: http://eprints.soton.ac.uk/id/eprint/479434
ISSN: 0140-6736
PURE UUID: 7268f118-deca-469a-bf18-add42d94b5bd
ORCID for Beth Stuart: ORCID iD orcid.org/0000-0001-5432-7437

Catalogue record

Date deposited: 24 Jul 2023 16:43
Last modified: 16 Aug 2024 01:41

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Contributors

Author: Ratna Wijaya
Author: Marina Johnson
Author: Nicola Campbell
Author: Beth Stuart ORCID iD
Author: Adam Kelly
Author: Nicole Tipler
Author: Tobias Menne
Author: Matthew J. Ahearne
Author: Victoria Willimott
Author: Anna Bowzyk Al-Naeeb
Author: Christopher P. Fox
Author: Graham P. Fox
Author: Graham P. Collins
Author: Ann O'Callaghan
Author: Andrew J. Davies
Author: David Goldblatt
Author: Sean H. Lim
Corporate Author: PROSECO investigators

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