Central macular choriocapillaris impairment as a manifestation of microvascular disease in eyes with subretinal drusenoid deposits
Central macular choriocapillaris impairment as a manifestation of microvascular disease in eyes with subretinal drusenoid deposits
Background/objectives: microvascular alterations and choroidal impairment are emerging as a pathologic pathway in age-related macular degeneration (AMD). This study aimed to evaluate the central macular choriocapillaris (CC) in eyes with subretinal drusenoid deposits (SDD) and the retinal microvasculature in patients with early AMD phenotypes.
Subjects/methods: this was an institutional, multicentric observational cross-sectional study. Ninety-nine eyes of 99 subjects; 33 eyes with SDD only, 33 eyes with conventional drusen (CD) only, and 33 eyes of healthy age-matched subjects were included. Comprehensive ophthalmologic examination and optical coherence tomography angiography (OCTA) was performed. The central macular flow area of the CC was analysed in the SDD group and the vessel density of the retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) was analysed in the SDD and CD groups using automated OCTA output parameters.
Results: the flow area of the CC in the SDD group was significantly reduced (p ≤ 0.001) with respect to the healthy control group. There was a trend of reduction of vessel density of the SCP and the DCP in the SDD and CD group with respect to controls, although this did not reach statistical significance.
Conclusions: OCTA data in the present report corroborate the role of vascular damage in early AMD with CC impairment in the central macular area in eyes with SDD.
eye diseases/complications, choriocapillaris, eyes, impairment, microvascular disease, subretinal drusenoid deposits
173-178
Abdolrahimzadeh, Solmaz
3aa4d304-cb8b-4830-8945-49261ac74993
Zweifel, Sandrine
ae1fd739-fc80-47ab-853f-6059033c7c72
Di Pippo, Mariachiara
1993f609-c150-4e15-832b-4a1b7821574b
Bajka, Anahita
d1a88de4-a30e-4d00-b3a0-b91e2b5c5f46
Scuderi, Gianluca
38e95e2e-eba5-4a10-a437-f7c28f36ea59
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
January 2024
Abdolrahimzadeh, Solmaz
3aa4d304-cb8b-4830-8945-49261ac74993
Zweifel, Sandrine
ae1fd739-fc80-47ab-853f-6059033c7c72
Di Pippo, Mariachiara
1993f609-c150-4e15-832b-4a1b7821574b
Bajka, Anahita
d1a88de4-a30e-4d00-b3a0-b91e2b5c5f46
Scuderi, Gianluca
38e95e2e-eba5-4a10-a437-f7c28f36ea59
Lotery, Andrew
5ecc2d2d-d0b4-468f-ad2c-df7156f8e514
Abdolrahimzadeh, Solmaz, Zweifel, Sandrine, Di Pippo, Mariachiara, Bajka, Anahita, Scuderi, Gianluca and Lotery, Andrew
(2024)
Central macular choriocapillaris impairment as a manifestation of microvascular disease in eyes with subretinal drusenoid deposits.
Eye, 38 (1), .
(doi:10.1038/s41433-023-02654-1).
Abstract
Background/objectives: microvascular alterations and choroidal impairment are emerging as a pathologic pathway in age-related macular degeneration (AMD). This study aimed to evaluate the central macular choriocapillaris (CC) in eyes with subretinal drusenoid deposits (SDD) and the retinal microvasculature in patients with early AMD phenotypes.
Subjects/methods: this was an institutional, multicentric observational cross-sectional study. Ninety-nine eyes of 99 subjects; 33 eyes with SDD only, 33 eyes with conventional drusen (CD) only, and 33 eyes of healthy age-matched subjects were included. Comprehensive ophthalmologic examination and optical coherence tomography angiography (OCTA) was performed. The central macular flow area of the CC was analysed in the SDD group and the vessel density of the retinal superficial capillary plexus (SCP) and deep capillary plexus (DCP) was analysed in the SDD and CD groups using automated OCTA output parameters.
Results: the flow area of the CC in the SDD group was significantly reduced (p ≤ 0.001) with respect to the healthy control group. There was a trend of reduction of vessel density of the SCP and the DCP in the SDD and CD group with respect to controls, although this did not reach statistical significance.
Conclusions: OCTA data in the present report corroborate the role of vascular damage in early AMD with CC impairment in the central macular area in eyes with SDD.
Text
s41433-023-02654-1
- Version of Record
More information
Accepted/In Press date: 21 June 2023
e-pub ahead of print date: 7 July 2023
Published date: January 2024
Additional Information:
Funding Information:
This research was supported by the Progetto di Ateneo Grant, Sapienza University of Rome, Italy (RP11916B7AC27CBC).
Publisher Copyright:
© 2023, The Author(s).
Keywords:
eye diseases/complications, choriocapillaris, eyes, impairment, microvascular disease, subretinal drusenoid deposits
Identifiers
Local EPrints ID: 479461
URI: http://eprints.soton.ac.uk/id/eprint/479461
ISSN: 0950-222X
PURE UUID: cf3e1b6e-0629-40b8-a49a-e7605e2773fd
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Date deposited: 24 Jul 2023 17:21
Last modified: 18 Mar 2024 02:57
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Contributors
Author:
Solmaz Abdolrahimzadeh
Author:
Sandrine Zweifel
Author:
Mariachiara Di Pippo
Author:
Anahita Bajka
Author:
Gianluca Scuderi
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