The University of Southampton
University of Southampton Institutional Repository

Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults

Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults
Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults
Procedural learning declines with age and appropriately timed light exposure can improve cognitive performance in older individuals. Because cataract reduces light transmission and is associated with cognitive decline in older adults, we explored whether lens replacement (intraocular blue-blocking [BB] or UV-only blocking) in older patients with cataracts enhances the beneficial effects of light on procedural learning. Healthy older participants (n = 16) and older patients with post-cataract surgery (n = 13 with BB or UV lens replacement) underwent a randomized within-subject crossover laboratory design with three protocols. In each protocol, 3.5 hr dim–dark adaptation was followed by 2 hr evening blue-enriched (6,500K) or non-blue-enriched light exposure (3,000K or 2,500K), 30 min dim post-light, ~8 hr sleep and 2 hr morning dim light. Procedural learning was assessed by the alternating serial reaction time task (ASRT), as part of a larger test battery. Here, ASRT performance was indexed by type of trial (random or sequence) and sequence-specific (high or low probability) measures. During evening light exposure, we observed a significant effect of the interaction of “group” versus “light condition” on the type of trial (p = .04; p = .16; unadjusted and adjusted p-values, respectively) and sequence-specific learning (p = .04; p = .16; unadjusted and adjusted p-values, respectively), whereby patients with UV lens replacement performed better than patients with BB lens or non-cataract controls, during blue-enriched light exposure. Lens replacement in patients with cataracts may potentially be associated with beneficial effects of blue light on procedural learning. Thus, optimizing spectral lens transmission in patients with cataracts may help improve specific aspects of cognitive function, such as procedural learning.
0962-1105
Chellappa, Sarah L.
516582b5-3cba-4644-86c9-14c91a4510f2
Bromundt, Vivien
e1f6228d-9b6f-4aa3-a785-475f283b30e3
Frey, Sylvia
9242fbd1-e165-4242-aa2f-d81a5823365d
Schlote, Torsten
4ce23d73-6a79-40c3-ba5f-214a87b5cc08
Goldblum, David
55652fee-de90-4618-bd19-237757627831
Cajochen, Christian
f605e720-e417-45dc-9b5c-244b1a1d6265
Reichert, Carolin F.
8beb084e-1d68-475e-8777-9e0380f0b594
Chellappa, Sarah L.
516582b5-3cba-4644-86c9-14c91a4510f2
Bromundt, Vivien
e1f6228d-9b6f-4aa3-a785-475f283b30e3
Frey, Sylvia
9242fbd1-e165-4242-aa2f-d81a5823365d
Schlote, Torsten
4ce23d73-6a79-40c3-ba5f-214a87b5cc08
Goldblum, David
55652fee-de90-4618-bd19-237757627831
Cajochen, Christian
f605e720-e417-45dc-9b5c-244b1a1d6265
Reichert, Carolin F.
8beb084e-1d68-475e-8777-9e0380f0b594

Chellappa, Sarah L., Bromundt, Vivien, Frey, Sylvia, Schlote, Torsten, Goldblum, David, Cajochen, Christian and Reichert, Carolin F. (2020) Intraocular cataract lens replacement and light exposure potentially impact procedural learning in older adults. Journal of Sleep Research. (doi:10.1111/jsr.13043).

Record type: Article

Abstract

Procedural learning declines with age and appropriately timed light exposure can improve cognitive performance in older individuals. Because cataract reduces light transmission and is associated with cognitive decline in older adults, we explored whether lens replacement (intraocular blue-blocking [BB] or UV-only blocking) in older patients with cataracts enhances the beneficial effects of light on procedural learning. Healthy older participants (n = 16) and older patients with post-cataract surgery (n = 13 with BB or UV lens replacement) underwent a randomized within-subject crossover laboratory design with three protocols. In each protocol, 3.5 hr dim–dark adaptation was followed by 2 hr evening blue-enriched (6,500K) or non-blue-enriched light exposure (3,000K or 2,500K), 30 min dim post-light, ~8 hr sleep and 2 hr morning dim light. Procedural learning was assessed by the alternating serial reaction time task (ASRT), as part of a larger test battery. Here, ASRT performance was indexed by type of trial (random or sequence) and sequence-specific (high or low probability) measures. During evening light exposure, we observed a significant effect of the interaction of “group” versus “light condition” on the type of trial (p = .04; p = .16; unadjusted and adjusted p-values, respectively) and sequence-specific learning (p = .04; p = .16; unadjusted and adjusted p-values, respectively), whereby patients with UV lens replacement performed better than patients with BB lens or non-cataract controls, during blue-enriched light exposure. Lens replacement in patients with cataracts may potentially be associated with beneficial effects of blue light on procedural learning. Thus, optimizing spectral lens transmission in patients with cataracts may help improve specific aspects of cognitive function, such as procedural learning.

This record has no associated files available for download.

More information

e-pub ahead of print date: 14 April 2020

Identifiers

Local EPrints ID: 479489
URI: http://eprints.soton.ac.uk/id/eprint/479489
ISSN: 0962-1105
PURE UUID: a4d01b85-99c6-456f-92db-855f2a4dfbe5
ORCID for Sarah L. Chellappa: ORCID iD orcid.org/0000-0002-6190-464X

Catalogue record

Date deposited: 25 Jul 2023 16:39
Last modified: 17 Mar 2024 04:20

Export record

Altmetrics

Contributors

Author: Sarah L. Chellappa ORCID iD
Author: Vivien Bromundt
Author: Sylvia Frey
Author: Torsten Schlote
Author: David Goldblum
Author: Christian Cajochen
Author: Carolin F. Reichert

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×