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Peritoneal fluid concentrations of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions

Cheong, Ying C., Shelton, Jenny B., Laird, Susan M., Li, Tin-Chiu, Ledger, William L. and Cooke, Ian D. (2003) Peritoneal fluid concentrations of matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and transforming growth factor-beta in women with pelvic adhesions Fertility and Sterility, 79, (5), pp. 1168-1175. (doi:10.1016/S0015-0282(03)00079-7).

Record type: Article

Abstract

Objective: to establish whether the concentration of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), and transforming growth factor-beta (TGF-beta) is influenced by the presence or absence of adhesions, and whether the concentration of these mediators vary throughout the menstrual cycle. Design: prospective case-control study. Setting: women undergoing laparoscopy in a university hospital in the United Kingdom. Patient(s): women undergoing laparoscopy for benign gynecological conditions. Intervention(s): samples of peritoneal fluid were collected at diagnostic laparoscopy in one group, and at laparoscopy and serially during the first 48 hours after laparoscopic adhesiolysis in a second group. We correlated the concentrations of mediators in serially sampled peritoneal fluid during the 48 hours following laparoscopic adhesiolysis to the adhesion formation and reformation found during second-look laparoscopy. Main outcome measures: the concentrations of MMP-9, TIMP-1, and TGF-beta in peritoneal fluid. Result(s): MMP-9 concentration was lower in the follicular phase than the luteal phase of the menstrual cycle. MMP-9 concentration was significantly lower in women with pelvic adhesions than in women with a normal pelvis. The MMP-9/TIMP-1 ratio is significantly higher in women with significant adhesions at second-look laparoscopy compared to women with minimal or no adhesions. Conclusion(s): the components of extracellular matrix remodeling may play an important part in the adhesion formation/reformation process.

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More information

Published date: May 2003
Keywords: adhesion, MMP, TIMP, TGF, peritoneal fluid, second-look laparoscopy, peritoneal drain

Identifiers

Local EPrints ID: 47953
URI: http://eprints.soton.ac.uk/id/eprint/47953
ISSN: 0015-0282
PURE UUID: 1c1a81f1-6f37-4071-89e6-338097dc1f20
ORCID for Ying C. Cheong: ORCID iD orcid.org/0000-0001-7687-4597

Catalogue record

Date deposited: 16 Aug 2007
Last modified: 17 Jul 2017 15:01

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Contributors

Author: Ying C. Cheong ORCID iD
Author: Jenny B. Shelton
Author: Susan M. Laird
Author: Tin-Chiu Li
Author: William L. Ledger
Author: Ian D. Cooke

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