The effects of procaine/haematoporphyrin on age-related decline: a double-blind trial
The effects of procaine/haematoporphyrin on age-related decline: a double-blind trial
A randomized, double-blind study of procaine/haematoporphyrin (KH3) has been carried out over two years in a selected population of healthy elderly subjects. The period of study exceeds 500 patient years. The trial population was weighted to contain a larger proportion of subjects aged over 75 years than a standard population; those receiving active KH3 had similar characteristics on entry to those receiving placebo. Over the course of two years, KH3 was shown to be an active substance in that: (a) decrement in the consolidation of new learning was prevented in the treatment group (less than 1.0%, as against 38% in the placebo group); (b) the prevalence of incontinence increased significantly in the placebo group, but not in the active group (P less than 0.05); (c) there was a significant increase in grip strength in the active treatment group (+22%, P less than 0.01 v. placebo); (d) more adverse reactions were observed on treatment with KH3 (P less than 0.005).
Aged, Aging/drug effects, Clinical Trials as Topic, Double-Blind Method, Drug Combinations/adverse effects, Female, Hematoporphyrins/adverse effects, Humans, Learning/drug effects, Male, Mental Recall/drug effects, Procaine/adverse effects, Random Allocation, Urinary Incontinence/prevention & control
302-308
Hall, M R
68b97e3b-4f5d-4fc5-8910-d7a8d4e8ce9a
Briggs, R S
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
MacLennan, W J
c03e8a8f-70bd-4120-939c-e7a14b18486a
Marcer, D
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Robinson, M J
ec4b7a0f-84cf-430d-b382-8ffacf2525b5
Everett, F M
62d20bab-b97a-467a-8327-d6f5bf2296ac
1 November 1983
Hall, M R
68b97e3b-4f5d-4fc5-8910-d7a8d4e8ce9a
Briggs, R S
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
MacLennan, W J
c03e8a8f-70bd-4120-939c-e7a14b18486a
Marcer, D
5b013080-d910-46e8-b45a-9e2ba84abd49
Robinson, M J
ec4b7a0f-84cf-430d-b382-8ffacf2525b5
Everett, F M
62d20bab-b97a-467a-8327-d6f5bf2296ac
Hall, M R, Briggs, R S, MacLennan, W J, Marcer, D, Robinson, M J and Everett, F M
(1983)
The effects of procaine/haematoporphyrin on age-related decline: a double-blind trial.
Age and Ageing, 12 (4), .
(doi:10.1093/ageing/12.4.302).
Abstract
A randomized, double-blind study of procaine/haematoporphyrin (KH3) has been carried out over two years in a selected population of healthy elderly subjects. The period of study exceeds 500 patient years. The trial population was weighted to contain a larger proportion of subjects aged over 75 years than a standard population; those receiving active KH3 had similar characteristics on entry to those receiving placebo. Over the course of two years, KH3 was shown to be an active substance in that: (a) decrement in the consolidation of new learning was prevented in the treatment group (less than 1.0%, as against 38% in the placebo group); (b) the prevalence of incontinence increased significantly in the placebo group, but not in the active group (P less than 0.05); (c) there was a significant increase in grip strength in the active treatment group (+22%, P less than 0.01 v. placebo); (d) more adverse reactions were observed on treatment with KH3 (P less than 0.005).
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Published date: 1 November 1983
Keywords:
Aged, Aging/drug effects, Clinical Trials as Topic, Double-Blind Method, Drug Combinations/adverse effects, Female, Hematoporphyrins/adverse effects, Humans, Learning/drug effects, Male, Mental Recall/drug effects, Procaine/adverse effects, Random Allocation, Urinary Incontinence/prevention & control
Identifiers
Local EPrints ID: 479562
URI: http://eprints.soton.ac.uk/id/eprint/479562
ISSN: 0002-0729
PURE UUID: 8a1fbaaf-7e26-4425-9c98-a15eecaf0174
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Date deposited: 26 Jul 2023 16:37
Last modified: 17 Mar 2024 03:42
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Author:
M R Hall
Author:
R S Briggs
Author:
W J MacLennan
Author:
D Marcer
Author:
M J Robinson
Author:
F M Everett
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