Subjective mood in young unmedicated depressed women under high and low sleep pressure conditions
Subjective mood in young unmedicated depressed women under high and low sleep pressure conditions
Diurnal mood variations are one of the core symptoms in depression, and total sleep deprivation (SD) can induce rapid, short-lasting clinical improvement in depressed patients. Here, we investigated if differential sleep pressure conditions impact on subjective mood levels in young women with major depressive disorder (MDD) without sleep disturbances, and in healthy controls. Eight healthy and eight MDD women underwent 40-h SD (high sleep pressure) and 40-h multiple NAP (low sleep pressure) protocols under constant routine conditions during which subjective mood was assessed every 30-min. MDD women rated overall significantly worse mood than controls, with minimal values for both groups during the biological night (ca. 4 a.m.), under high and low sleep pressure conditions. During SD, nighttime mood ratings in MDD women were lower than in controls and partially recovered during the second day of SD, but never attained control levels. The degree of this diurnal time-course in mood under SD correlated positively with sleep quality in MDD women. Our data indicate that MDD women without sleep disturbances did not exhibit a SD-induced antidepressant response, suggesting that the mood enhancement response to sleep deprivation might be related to the co-existence of sleep disturbances, which is an association that remains to be fully established.
Birchler-Pedross, Angelina
c1d4bc9c-5ffa-4f15-ba6d-2c477a49ec42
Frey, Sylvia
1f9b67ba-1ddf-4364-95ca-4188449eccfb
Götz, Thomas
476691a8-d896-409c-8073-386508c7368b
Brunner, Patrick
08714219-251f-42ba-9963-838793826d15
Knoblauch, Vera
88072dbd-a484-4a60-b887-ff6300899b21
Wirz-Justice, Anna
d27caf13-6f36-48a8-bbb5-11295c6ad2d1
Chellappa, Sarah L.
516582b5-3cba-4644-86c9-14c91a4510f2
Cajochen, Christian
f605e720-e417-45dc-9b5c-244b1a1d6265
16 December 2016
Birchler-Pedross, Angelina
c1d4bc9c-5ffa-4f15-ba6d-2c477a49ec42
Frey, Sylvia
1f9b67ba-1ddf-4364-95ca-4188449eccfb
Götz, Thomas
476691a8-d896-409c-8073-386508c7368b
Brunner, Patrick
08714219-251f-42ba-9963-838793826d15
Knoblauch, Vera
88072dbd-a484-4a60-b887-ff6300899b21
Wirz-Justice, Anna
d27caf13-6f36-48a8-bbb5-11295c6ad2d1
Chellappa, Sarah L.
516582b5-3cba-4644-86c9-14c91a4510f2
Cajochen, Christian
f605e720-e417-45dc-9b5c-244b1a1d6265
Birchler-Pedross, Angelina, Frey, Sylvia, Götz, Thomas, Brunner, Patrick, Knoblauch, Vera, Wirz-Justice, Anna, Chellappa, Sarah L. and Cajochen, Christian
(2016)
Subjective mood in young unmedicated depressed women under high and low sleep pressure conditions.
Biology, 5 (4).
(doi:10.3390/biology5040052).
Abstract
Diurnal mood variations are one of the core symptoms in depression, and total sleep deprivation (SD) can induce rapid, short-lasting clinical improvement in depressed patients. Here, we investigated if differential sleep pressure conditions impact on subjective mood levels in young women with major depressive disorder (MDD) without sleep disturbances, and in healthy controls. Eight healthy and eight MDD women underwent 40-h SD (high sleep pressure) and 40-h multiple NAP (low sleep pressure) protocols under constant routine conditions during which subjective mood was assessed every 30-min. MDD women rated overall significantly worse mood than controls, with minimal values for both groups during the biological night (ca. 4 a.m.), under high and low sleep pressure conditions. During SD, nighttime mood ratings in MDD women were lower than in controls and partially recovered during the second day of SD, but never attained control levels. The degree of this diurnal time-course in mood under SD correlated positively with sleep quality in MDD women. Our data indicate that MDD women without sleep disturbances did not exhibit a SD-induced antidepressant response, suggesting that the mood enhancement response to sleep deprivation might be related to the co-existence of sleep disturbances, which is an association that remains to be fully established.
Text
biology-05-00052
- Version of Record
More information
Accepted/In Press date: 29 November 2016
Published date: 16 December 2016
Identifiers
Local EPrints ID: 479595
URI: http://eprints.soton.ac.uk/id/eprint/479595
ISSN: 2079-7737
PURE UUID: 3a6bf7ea-b3c2-454d-bf30-9251db3552e8
Catalogue record
Date deposited: 26 Jul 2023 16:40
Last modified: 17 Mar 2024 04:20
Export record
Altmetrics
Contributors
Author:
Angelina Birchler-Pedross
Author:
Sylvia Frey
Author:
Thomas Götz
Author:
Patrick Brunner
Author:
Vera Knoblauch
Author:
Anna Wirz-Justice
Author:
Sarah L. Chellappa
Author:
Christian Cajochen
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics