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Nutrition for the ageing brain: Towards evidence for an optimal diet

Nutrition for the ageing brain: Towards evidence for an optimal diet
Nutrition for the ageing brain: Towards evidence for an optimal diet

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.

Cognition, Cognitive ageing, Cognitive decline, Neuroinflammation, Neuroprotection, Preventive diet
1568-1637
222-240
Vauzour, David
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Camprubi-Robles, Maria
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Miquel-Kergoat, Sophie
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Andres-Lacueva, Cristina
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Bánáti, Diána
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Barberger-Gateau, Pascale
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Bowman, Gene L.
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Caberlotto, Laura
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Clarke, Robert
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Hogervorst, Eef
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Kiliaan, Amanda J.
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Lucca, Ugo
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Manach, Claudine
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Minihane, Anne-Marie
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Mitchell, Ellen Siobhan
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Perneczky, Robert
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Perry, Hugh
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Roussel, Anne Marie
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Schuermans, Jeroen
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Sijben, John
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Spencer, Jeremy P.E.
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Thuret, Sandrine
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van de Rest, Ondine
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Vandewoude, Maurits
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Wesnes, Keith
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Williams, Robert J.
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Williams, Robin S.B.
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Ramirez, Maria
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Vauzour, David
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Camprubi-Robles, Maria
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Miquel-Kergoat, Sophie
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Andres-Lacueva, Cristina
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Bánáti, Diána
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Barberger-Gateau, Pascale
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Bowman, Gene L.
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Caberlotto, Laura
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Clarke, Robert
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Hogervorst, Eef
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Kiliaan, Amanda J.
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Lucca, Ugo
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Manach, Claudine
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Minihane, Anne-Marie
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Mitchell, Ellen Siobhan
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Perneczky, Robert
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Perry, Hugh
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Roussel, Anne Marie
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Schuermans, Jeroen
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Sijben, John
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Spencer, Jeremy P.E.
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Thuret, Sandrine
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van de Rest, Ondine
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Vandewoude, Maurits
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Wesnes, Keith
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Williams, Robert J.
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Williams, Robin S.B.
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Ramirez, Maria
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Vauzour, David, Camprubi-Robles, Maria, Miquel-Kergoat, Sophie, Andres-Lacueva, Cristina, Bánáti, Diána, Barberger-Gateau, Pascale, Bowman, Gene L., Caberlotto, Laura, Clarke, Robert, Hogervorst, Eef, Kiliaan, Amanda J., Lucca, Ugo, Manach, Claudine, Minihane, Anne-Marie, Mitchell, Ellen Siobhan, Perneczky, Robert, Perry, Hugh, Roussel, Anne Marie, Schuermans, Jeroen, Sijben, John, Spencer, Jeremy P.E., Thuret, Sandrine, van de Rest, Ondine, Vandewoude, Maurits, Wesnes, Keith, Williams, Robert J., Williams, Robin S.B. and Ramirez, Maria (2017) Nutrition for the ageing brain: Towards evidence for an optimal diet. Ageing Research Reviews, 35, 222-240. (doi:10.1016/j.arr.2016.09.010).

Record type: Review

Abstract

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.

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More information

Accepted/In Press date: 29 September 2016
e-pub ahead of print date: 15 March 2017
Published date: 1 May 2017
Keywords: Cognition, Cognitive ageing, Cognitive decline, Neuroinflammation, Neuroprotection, Preventive diet

Identifiers

Local EPrints ID: 479606
URI: http://eprints.soton.ac.uk/id/eprint/479606
ISSN: 1568-1637
PURE UUID: 49704883-7dbc-4ddb-8e1c-457cf9be446c

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Date deposited: 26 Jul 2023 16:41
Last modified: 10 May 2024 17:01

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Contributors

Author: David Vauzour
Author: Maria Camprubi-Robles
Author: Sophie Miquel-Kergoat
Author: Cristina Andres-Lacueva
Author: Diána Bánáti
Author: Pascale Barberger-Gateau
Author: Gene L. Bowman
Author: Laura Caberlotto
Author: Robert Clarke
Author: Eef Hogervorst
Author: Amanda J. Kiliaan
Author: Ugo Lucca
Author: Claudine Manach
Author: Anne-Marie Minihane
Author: Ellen Siobhan Mitchell
Author: Robert Perneczky
Author: Hugh Perry
Author: Anne Marie Roussel
Author: Jeroen Schuermans
Author: John Sijben
Author: Jeremy P.E. Spencer
Author: Sandrine Thuret
Author: Ondine van de Rest
Author: Maurits Vandewoude
Author: Keith Wesnes
Author: Robert J. Williams
Author: Robin S.B. Williams
Author: Maria Ramirez

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