Impact of Circadian Disruption on Cardiovascular Function and Disease
Impact of Circadian Disruption on Cardiovascular Function and Disease
The circadian system, that is ubiquitous across species, generates ∼24 h rhythms in virtually all biological processes, and allows them to anticipate and adapt to the 24 h day/night cycle, thus ensuring optimal physiological function. Epidemiological studies show time-of-day variations in adverse cardiovascular (CV) events, and controlled laboratory studies demonstrate a circadian influence on key markers of CV function and risk. Furthermore, circadian misalignment, that is typically experienced by shift workers as well as by individuals who experience late eating, (social) jet lag, or circadian rhythm sleep-wake disturbances, increases CV risk factors. Therefore, understanding the mechanisms by which the circadian system regulates CV function, and which of these are affected by circadian disruption, may help to develop intervention strategies to mitigate CV risk.
767-779
Chellappa, Sarah
516582b5-3cba-4644-86c9-14c91a4510f2
Vujovic, Nina
df8c5f67-c138-4a62-ba41-0d390d209924
Williams, Jonathan
ad209a5e-c71e-4b7b-ab8a-a2d3fad464fb
Scheer, Frank
78a5044a-b185-46d3-a3cf-3916e5309056
3 October 2019
Chellappa, Sarah
516582b5-3cba-4644-86c9-14c91a4510f2
Vujovic, Nina
df8c5f67-c138-4a62-ba41-0d390d209924
Williams, Jonathan
ad209a5e-c71e-4b7b-ab8a-a2d3fad464fb
Scheer, Frank
78a5044a-b185-46d3-a3cf-3916e5309056
Chellappa, Sarah, Vujovic, Nina, Williams, Jonathan and Scheer, Frank
(2019)
Impact of Circadian Disruption on Cardiovascular Function and Disease.
Trends in Endocrinology and Metabolism: TEM, 30 (10), .
(doi:10.1016/j.tem.2019.07.008).
Abstract
The circadian system, that is ubiquitous across species, generates ∼24 h rhythms in virtually all biological processes, and allows them to anticipate and adapt to the 24 h day/night cycle, thus ensuring optimal physiological function. Epidemiological studies show time-of-day variations in adverse cardiovascular (CV) events, and controlled laboratory studies demonstrate a circadian influence on key markers of CV function and risk. Furthermore, circadian misalignment, that is typically experienced by shift workers as well as by individuals who experience late eating, (social) jet lag, or circadian rhythm sleep-wake disturbances, increases CV risk factors. Therefore, understanding the mechanisms by which the circadian system regulates CV function, and which of these are affected by circadian disruption, may help to develop intervention strategies to mitigate CV risk.
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e-pub ahead of print date: 16 August 2019
Published date: 3 October 2019
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Local EPrints ID: 479629
URI: http://eprints.soton.ac.uk/id/eprint/479629
PURE UUID: 40ab6d00-71b1-482c-89f9-bd6403ab75ad
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Date deposited: 26 Jul 2023 16:42
Last modified: 17 Mar 2024 04:20
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Author:
Sarah Chellappa
Author:
Nina Vujovic
Author:
Jonathan Williams
Author:
Frank Scheer
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