Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
253-255
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Ward, Daniel
8343934a-ac4c-4042-ad30-93270144f77d
Murray, Anna
2c3bf35c-26dd-427d-9673-ccbfa7f17e9a
February 2006
Ennis, Sarah
7b57f188-9d91-4beb-b217-09856146f1e9
Ward, Daniel
8343934a-ac4c-4042-ad30-93270144f77d
Murray, Anna
2c3bf35c-26dd-427d-9673-ccbfa7f17e9a
Ennis, Sarah, Ward, Daniel and Murray, Anna
(2006)
Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers.
European Journal of Human Genetics, 14 (2), .
(doi:10.1038/sj.ejhg.5201510).
Abstract
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.
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Published date: February 2006
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Local EPrints ID: 47963
URI: http://eprints.soton.ac.uk/id/eprint/47963
ISSN: 1018-4813
PURE UUID: c145a6b7-ce4d-456c-92f5-483d4b0a3bf2
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Date deposited: 16 Aug 2007
Last modified: 16 Mar 2024 03:07
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Author:
Daniel Ward
Author:
Anna Murray
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