Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers


Ennis, Sarah, Ward, Daniel and Murray, Anna (2006) Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers European Journal of Human Genetics, 14, (2), pp. 253-255. (doi:10.1038/sj.ejhg.5201510).

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Description/Abstract

FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1038/sj.ejhg.5201510
ISSNs: 1018-4813 (print)
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ePrint ID: 47963
Date :
Date Event
February 2006Published
Date Deposited: 16 Aug 2007
Last Modified: 16 Apr 2017 18:26
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/47963

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