Silencing synapses: A route to understanding synapse degeneration in chronic neurodegenerative disease
Silencing synapses: A route to understanding synapse degeneration in chronic neurodegenerative disease
The degeneration of pre-synaptic boutons in the stratum radiatum of the dorsal hippocampus is one of earliest components of neurodegeneration in several models of murine prion disease. We recently showed that blockade of synaptic transmission by infusion of botulinum neurotoxin A (BoNT/A) into the hippocampus several weeks prior to the onset of degeneration, had no detectable impact on the extent of the synaptic degeneration.1 We elaborate here on the rationale for these experiments and highlight why we believe that this negative result is interesting and important. We also discuss new observations that might provide insights into the molecular events that underlie synapse degeneration.
Mouse hippocampus, Neuronal activity, Protein misfolding diseases, SNAP-25, SNARE complex, Synaptic degeneration, Synaptic vesicle exocytosis, Synaptic vesicle recycling
147-150
Caleo, Matteo
f40884a6-2b30-4dc8-bbb8-47dfdc5cf2bc
Restani, Laura
6c20fd33-f21d-491b-bd4f-e37846571393
Hugh Perry, V.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Caleo, Matteo
f40884a6-2b30-4dc8-bbb8-47dfdc5cf2bc
Restani, Laura
6c20fd33-f21d-491b-bd4f-e37846571393
Hugh Perry, V.
8f29d36a-8e1f-4082-8700-09483bbaeae4
Caleo, Matteo, Restani, Laura and Hugh Perry, V.
(2013)
Silencing synapses: A route to understanding synapse degeneration in chronic neurodegenerative disease.
PRION, 7 (2), .
(doi:10.4161/pri.23327).
Abstract
The degeneration of pre-synaptic boutons in the stratum radiatum of the dorsal hippocampus is one of earliest components of neurodegeneration in several models of murine prion disease. We recently showed that blockade of synaptic transmission by infusion of botulinum neurotoxin A (BoNT/A) into the hippocampus several weeks prior to the onset of degeneration, had no detectable impact on the extent of the synaptic degeneration.1 We elaborate here on the rationale for these experiments and highlight why we believe that this negative result is interesting and important. We also discuss new observations that might provide insights into the molecular events that underlie synapse degeneration.
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Accepted/In Press date: 18 December 2012
e-pub ahead of print date: 28 January 2013
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Restricted access, rolling paywall
Keywords:
Mouse hippocampus, Neuronal activity, Protein misfolding diseases, SNAP-25, SNARE complex, Synaptic degeneration, Synaptic vesicle exocytosis, Synaptic vesicle recycling
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Local EPrints ID: 479650
URI: http://eprints.soton.ac.uk/id/eprint/479650
ISSN: 1933-6896
PURE UUID: 8352dbd5-cc2b-4b4d-a2d8-c0ceb0d89d73
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Date deposited: 26 Jul 2023 16:44
Last modified: 17 Mar 2024 00:22
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Author:
Matteo Caleo
Author:
Laura Restani
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