Clinical and urodynamic effects of ephedrine in elderly incontinent patients
Clinical and urodynamic effects of ephedrine in elderly incontinent patients
The effect of ephedrine, an adrenergic receptor agonist, was investigated in 24 elderly patients with urinary incontinence associated with unstable detrusor contractions. After 3 weeks of oral ephedrine repeat cystometry showed mean increases of 21 per cent in bladder capacity and of 23 per cent in urethral pressure. Of 21 patients studied 7 became continent and 12 were improved. However, the urodynamic improvement did not reach statistical significance even in the continent group and, thus, the clinical improvement was unlikely to be owing to ephedrine. Therefore, open studies of drug treatment for detrusor instability may be misleading unless clinical and cystometric data are obtained.
Aged, Ephedrine/therapeutic use, Humans, Male, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Pressure, Urethra/drug effects, Urinary Bladder/drug effects, Urinary Incontinence/drug therapy, Urodynamics/drug effects
1250-2
Castleden, C M
ace1cafc-d68f-4b09-ad97-e8cd3056600d
Duffin, H M
2b238b9a-03d7-4baa-967f-00422112888c
Briggs, R S
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Ogden, B M
26e7c04c-c21e-4d82-8faf-ab8009c1ad22
1 December 1982
Castleden, C M
ace1cafc-d68f-4b09-ad97-e8cd3056600d
Duffin, H M
2b238b9a-03d7-4baa-967f-00422112888c
Briggs, R S
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Ogden, B M
26e7c04c-c21e-4d82-8faf-ab8009c1ad22
Castleden, C M, Duffin, H M, Briggs, R S and Ogden, B M
(1982)
Clinical and urodynamic effects of ephedrine in elderly incontinent patients.
The Journal of Urology, 128 (6), .
(doi:10.1016/s0022-5347(17)53448-5).
Abstract
The effect of ephedrine, an adrenergic receptor agonist, was investigated in 24 elderly patients with urinary incontinence associated with unstable detrusor contractions. After 3 weeks of oral ephedrine repeat cystometry showed mean increases of 21 per cent in bladder capacity and of 23 per cent in urethral pressure. Of 21 patients studied 7 became continent and 12 were improved. However, the urodynamic improvement did not reach statistical significance even in the continent group and, thus, the clinical improvement was unlikely to be owing to ephedrine. Therefore, open studies of drug treatment for detrusor instability may be misleading unless clinical and cystometric data are obtained.
This record has no associated files available for download.
More information
Published date: 1 December 1982
Keywords:
Aged, Ephedrine/therapeutic use, Humans, Male, Muscle Contraction/drug effects, Muscle, Smooth/drug effects, Pressure, Urethra/drug effects, Urinary Bladder/drug effects, Urinary Incontinence/drug therapy, Urodynamics/drug effects
Identifiers
Local EPrints ID: 479671
URI: http://eprints.soton.ac.uk/id/eprint/479671
ISSN: 0022-5347
PURE UUID: 8fb5d13f-700b-4a2c-9840-c3da15cb3ecd
Catalogue record
Date deposited: 26 Jul 2023 16:46
Last modified: 17 Mar 2024 03:42
Export record
Altmetrics
Contributors
Author:
C M Castleden
Author:
H M Duffin
Author:
R S Briggs
Author:
B M Ogden
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics