Chronobiology, excessive daytime sleepiness and depression: Is there a link?
Chronobiology, excessive daytime sleepiness and depression: Is there a link?
The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical practice, may arise from a variety of psychiatric disorders, most importantly depression. Even though EDS frequently leads depressed patients to seek medical assistance, it is commonly under-evaluated and under-diagnosed. Therefore, a comprehensive understanding and management of EDS is essential in the clinical assessment of depression. Within a theoretical framework, a chronobiological approach may shed new light on the complex interaction of EDS and depression. In this review, studies on EDS and depression are summarized and discussed within the context of circadian and sleep regulatory mechanisms. Furthermore, potential chronobiological therapeutic strategies are proposed to address some of the unmet needs in the treatment of EDS and depression.
505-514
Chellappa, SL
516582b5-3cba-4644-86c9-14c91a4510f2
Schröder, C
e285bc00-4404-4024-a524-c07c5b0c22a3
Cajochen, C
f605e720-e417-45dc-9b5c-244b1a1d6265
27 September 2008
Chellappa, SL
516582b5-3cba-4644-86c9-14c91a4510f2
Schröder, C
e285bc00-4404-4024-a524-c07c5b0c22a3
Cajochen, C
f605e720-e417-45dc-9b5c-244b1a1d6265
Chellappa, SL, Schröder, C and Cajochen, C
(2008)
Chronobiology, excessive daytime sleepiness and depression: Is there a link?
Sleep Medicine, .
(doi:10.1016/j.sleep.2008.05.010).
Abstract
The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical practice, may arise from a variety of psychiatric disorders, most importantly depression. Even though EDS frequently leads depressed patients to seek medical assistance, it is commonly under-evaluated and under-diagnosed. Therefore, a comprehensive understanding and management of EDS is essential in the clinical assessment of depression. Within a theoretical framework, a chronobiological approach may shed new light on the complex interaction of EDS and depression. In this review, studies on EDS and depression are summarized and discussed within the context of circadian and sleep regulatory mechanisms. Furthermore, potential chronobiological therapeutic strategies are proposed to address some of the unmet needs in the treatment of EDS and depression.
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Published date: 27 September 2008
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Local EPrints ID: 479700
URI: http://eprints.soton.ac.uk/id/eprint/479700
ISSN: 1389-9457
PURE UUID: c9348d05-80f7-451f-9090-5256c7e0ce20
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Date deposited: 26 Jul 2023 16:49
Last modified: 17 Mar 2024 04:20
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Author:
SL Chellappa
Author:
C Schröder
Author:
C Cajochen
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