New insights into hepatitis C
New insights into hepatitis C
Hepatitis C infection is characterised by three key features, which are the consequence of a complex interaction between genetic determinants of immune and other host factors and viral characteristics: 1. A high rate of viral persistence after acute infection resulting from a combination of weak T cell responsiveness and specific viral mechanisms of immune escape. 2. Marked interindividual variability in end-organ damage (fibrosis and cirrhosis), probably due to host genetic polymorphisms in genes governing the immune response and fibrosis pathways in addition to viral pathogenicity factors. 3. Significant resistance to antiviral therapies. Viral mechanisms of antiviral resistance parallel those of viral persistence, and include the intriguing possibility that hepatitis C may infect immunologically privileged sites such as the central nervous system.
Antiviral Agents/pharmacology, Disease Progression, Drug Resistance, Microbial, Hepatitis C, Chronic/drug therapy, Humans, Liver Cirrhosis/virology, Polymorphism, Genetic, Risk Factors
554-559
Forton, D M
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Wright, M
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Knapp, S
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Thursz, M R
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Taylor-Robinson, S D
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Thomas, Howard C
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1 November 2002
Forton, D M
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Wright, M
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Knapp, S
b7e3f8e9-0b4b-4433-8077-d6e3fbf4ccee
Thursz, M R
efe8e73d-555b-4b44-a8be-e77a8809208d
Taylor-Robinson, S D
c9a946ff-a1f1-477f-b6d1-fe247a7a875f
Thomas, Howard C
5f9655ae-da0a-4e31-ab66-e0a7a2874e84
Forton, D M, Wright, M, Knapp, S, Thursz, M R, Taylor-Robinson, S D and Thomas, Howard C
(2002)
New insights into hepatitis C.
Clinical Medicine, 2 (6), .
(doi:10.7861/clinmedicine.2-6-554).
Abstract
Hepatitis C infection is characterised by three key features, which are the consequence of a complex interaction between genetic determinants of immune and other host factors and viral characteristics: 1. A high rate of viral persistence after acute infection resulting from a combination of weak T cell responsiveness and specific viral mechanisms of immune escape. 2. Marked interindividual variability in end-organ damage (fibrosis and cirrhosis), probably due to host genetic polymorphisms in genes governing the immune response and fibrosis pathways in addition to viral pathogenicity factors. 3. Significant resistance to antiviral therapies. Viral mechanisms of antiviral resistance parallel those of viral persistence, and include the intriguing possibility that hepatitis C may infect immunologically privileged sites such as the central nervous system.
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More information
Published date: 1 November 2002
Keywords:
Antiviral Agents/pharmacology, Disease Progression, Drug Resistance, Microbial, Hepatitis C, Chronic/drug therapy, Humans, Liver Cirrhosis/virology, Polymorphism, Genetic, Risk Factors
Identifiers
Local EPrints ID: 479773
URI: http://eprints.soton.ac.uk/id/eprint/479773
ISSN: 1470-2118
PURE UUID: 6ab10df5-700d-4994-8806-0f6a8c0ea547
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Date deposited: 26 Jul 2023 17:00
Last modified: 17 Mar 2024 02:14
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Contributors
Author:
D M Forton
Author:
M Wright
Author:
S Knapp
Author:
M R Thursz
Author:
S D Taylor-Robinson
Author:
Howard C Thomas
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