Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci

Accepted/In Press date: 19 May 2023

e-pub ahead of print date: 29 June 2023

Published date: July 2023

Additional Information: Funding Information: The opinions expressed in this manuscript are the authors’ own and do not reflect the views of the Canadian Longitudinal Study on Aging (CLSA) or any affiliated institution. This project used data from the UK Biobank under application no. 25331. We acknowledge Mass General Brigham Biobank for providing samples, genomic data and health information data. We acknowledge the participants and investigators of the FinnGen study. This research was made possible using the data/biospecimens collected by the CLSA. Funding for the CLSA is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant no. LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces: Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta and British Columbia. This research has been conducted using the CLSA dataset (Baseline Comprehensive Dataset version 4.0, Follow-up 1 Comprehensive Dataset version 1.0), under Application Number 190225. The CLSA is led by P. Raina, C. Wolfson and S. Kirkland. S.M. is supported by a research fellowship from the Australian National Health and Medical Research Council (NHMRC). S.M., D.A.M., J.E.C. and A.W.H. acknowledge Program Grant (grant no. 1150144) and Centre of Research Excellence (grant no. 1116360) Funding from the Australian NHMRC. P.G. is supported by an NHMRC Investigator Grant (#1173390). J.L.W. acknowledges support from NIH NEI R01 EY022305 and P30 EY014104. L.R.P. is supported by Research to Prevent Blindness (NYC, USA), the Glaucoma Foundation (NYC, USA) and grant nos. NEI R01 EY 015473 and EY 032559. A.V.S., A.R.H. and P.M. were supported by NIH/NEI grant no. R01 EY031424. A.P.K. is supported by a UK Research and Innovation Future Leaders Fellowship, an Alcon Research Institute Young Investigator Award and a Lister Institute for Preventive Medicine Award. This research was supported by the NIHR Biomedical Research Centre at Moorfields Eye Hospital and the UCL Institute of Ophthalmology. We acknowledge a Core Grant for Vision Research from the National Eye Institute/National Institutes of Healthto the University of Wisconsin–Madison (P30EY016665) and an Unrestricted Grant from Research to Prevent Blindness,Inc. to the UW-Madison Department of Ophthalmology and Visual Sciences. We acknowledge the donors of National Glaucoma Research, a program of the BrightFocus Foundation, for support of this research (BrightFocus Grant Submission Number: G2021009S). Funding Information: The opinions expressed in this manuscript are the authors’ own and do not reflect the views of the Canadian Longitudinal Study on Aging (CLSA) or any affiliated institution. This project used data from the UK Biobank under application no. 25331. We acknowledge Mass General Brigham Biobank for providing samples, genomic data and health information data. We acknowledge the participants and investigators of the FinnGen study. This research was made possible using the data/biospecimens collected by the CLSA. Funding for the CLSA is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant no. LSA 94473 and the Canada Foundation for Innovation, as well as the following provinces: Newfoundland, Nova Scotia, Quebec, Ontario, Manitoba, Alberta and British Columbia. This research has been conducted using the CLSA dataset (Baseline Comprehensive Dataset version 4.0, Follow-up 1 Comprehensive Dataset version 1.0), under Application Number 190225. The CLSA is led by P. Raina, C. Wolfson and S. Kirkland. S.M. is supported by a research fellowship from the Australian National Health and Medical Research Council (NHMRC). S.M., D.A.M., J.E.C. and A.W.H. acknowledge Program Grant (grant no. 1150144) and Centre of Research Excellence (grant no. 1116360) Funding from the Australian NHMRC. P.G. is supported by an NHMRC Investigator Grant (#1173390). J.L.W. acknowledges support from NIH NEI R01 EY022305 and P30 EY014104. L.R.P. is supported by Research to Prevent Blindness (NYC, USA), the Glaucoma Foundation (NYC, USA) and grant nos. NEI R01 EY 015473 and EY 032559. A.V.S., A.R.H. and P.M. were supported by NIH/NEI grant no. R01 EY031424. A.P.K. is supported by a UK Research and Innovation Future Leaders Fellowship, an Alcon Research Institute Young Investigator Award and a Lister Institute for Preventive Medicine Award. This research was supported by the NIHR Biomedical Research Centre at Moorfields Eye Hospital and the UCL Institute of Ophthalmology. We acknowledge a Core Grant for Vision Research from the National Eye Institute/National Institutes of Healthto the University of Wisconsin–Madison (P30EY016665) and an Unrestricted Grant from Research to Prevent Blindness,Inc. to the UW-Madison Department of Ophthalmology and Visual Sciences. We acknowledge the donors of National Glaucoma Research, a program of the BrightFocus Foundation, for support of this research (BrightFocus Grant Submission Number: G2021009S). Publisher Copyright: © 2023, The Author(s).

Keywords: eye, genome-wide, glaucoma risk loci, multitrait

Local EPrints ID: 479807

URI: http://eprints.soton.ac.uk/id/eprint/479807

DOI: doi:10.1038/s41588-023-01428-5

ISSN: 1061-4036

PURE UUID: 10a327b9-e399-4bef-a497-9affac6b9203

ORCID for Andrew Lotery: orcid.org/0000-0001-5541-4305

Date deposited: 26 Jul 2023 17:12

Last modified: 18 Mar 2024 02:57