Phospholipids in the nucleus--metabolism and possible functions
Phospholipids in the nucleus--metabolism and possible functions
Most of the phospholipids in the nuclear envelope are contained in the double nuclear membrane, and this has an active lipid metabolism consistent with its origins as a component of the endoplasmic reticular system. However, even after removal of the nuclear membrane with detergents, some phospholipids, mostly of unknown location and function, remain. Amongst these are all of the components of what appears to be a nuclear polyphosphoinositide signalling system, distinct from the well-established inositide pathway found in the plasma membrane. The consequences for nuclear function of the activation of these two inositide pathways are discussed, with a detailed consideration of proposed intranuclear functions for protein kinase C, and the maintenance of nuclear Ca2+ homoeostasis.
225-235
Irvine, R. F.
a8a94b1b-419c-4262-b745-eae1941ce145
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
1992
Irvine, R. F.
a8a94b1b-419c-4262-b745-eae1941ce145
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Irvine, R. F. and Divecha, N.
(1992)
Phospholipids in the nucleus--metabolism and possible functions.
Seminars in Cell and Developmental Biology, 3 (4), .
(doi:10.1016/1043-4682(92)90024-p).
Abstract
Most of the phospholipids in the nuclear envelope are contained in the double nuclear membrane, and this has an active lipid metabolism consistent with its origins as a component of the endoplasmic reticular system. However, even after removal of the nuclear membrane with detergents, some phospholipids, mostly of unknown location and function, remain. Amongst these are all of the components of what appears to be a nuclear polyphosphoinositide signalling system, distinct from the well-established inositide pathway found in the plasma membrane. The consequences for nuclear function of the activation of these two inositide pathways are discussed, with a detailed consideration of proposed intranuclear functions for protein kinase C, and the maintenance of nuclear Ca2+ homoeostasis.
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Published date: 1992
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Local EPrints ID: 480060
URI: http://eprints.soton.ac.uk/id/eprint/480060
ISSN: 1043-4682
PURE UUID: d9a125f9-1378-4529-9892-df1f2208f89e
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Date deposited: 01 Aug 2023 16:40
Last modified: 17 Mar 2024 02:59
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Author:
R. F. Irvine
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