An emerging role for PtdIns(4,5)P2-mediated signalling in human disease
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease
Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.
Animals Bipolar Disorder/*metabolism Heart Diseases/*metabolism Humans Ion Channels/*metabolism Oculocerebrorenal Syndrome/*metabolism Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates/*metabolism *Signal Transduction
654-660
Halstead, J. R.
019c9dab-c338-4f97-9318-353858ea82ac
Jalink, K.
81124fdb-185d-43c1-a659-cd22dd2d381c
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Halstead, J. R.
019c9dab-c338-4f97-9318-353858ea82ac
Jalink, K.
81124fdb-185d-43c1-a659-cd22dd2d381c
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Halstead, J. R., Jalink, K. and Divecha, N.
(2005)
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease.
Trends in Pharmacological Sciences, 26 (12), .
(doi:10.1016/j.tips.2005.10.004).
Abstract
Although an established regulator of many cellular functions, the phosphoinositide phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2) appears to have evaded the attention of drug-discovery companies. An increasing number of reports have identified potential links between PtdIns(4,5)P2-mediated signalling pathways and the aetiology of many human diseases. Here, we review current knowledge of the regulation and function of PtdIns(4,5)P2 and discuss how aberrant PtdIns(4,5)P2-mediated signalling might contribute to human pathologies such as cardiac failure, bipolar disorder, channelopathies and the genetic disorder Lowe syndrome.
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e-pub ahead of print date: 25 October 2005
Keywords:
Animals Bipolar Disorder/*metabolism Heart Diseases/*metabolism Humans Ion Channels/*metabolism Oculocerebrorenal Syndrome/*metabolism Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates/*metabolism *Signal Transduction
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Local EPrints ID: 480075
URI: http://eprints.soton.ac.uk/id/eprint/480075
ISSN: 0165-6147
PURE UUID: b7cb9664-ea9d-42d1-99d6-304bbf5c03b3
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Date deposited: 01 Aug 2023 16:43
Last modified: 17 Mar 2024 02:59
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Author:
J. R. Halstead
Author:
K. Jalink
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