Linking lipids to chromatin
Linking lipids to chromatin
Dynamic regulation of chromatin structure is thought to be a prerequisite for nuclear functions that require accessibility to DNA such as replication, transcription and DNA repair. The phosphoinositide (PI) pathway is a second messenger signalling system regulated in response to a variety of extracellular (growth factors, differentiation signals) and intracellular (cell cycle progression, DNA damage) stimuli. The presence of a PI pathway in the nucleus together with the recent findings that specific nuclear proteins can interact with and are regulated by phosphoinositides suggest that changes in the nuclear phosphoinositide profile may have a direct role in modulating chromatin structure.
Chromatin/*metabolism Chromatin Assembly and Disassembly/*physiology Humans Phosphatidylinositol Phosphates/metabolism Phosphatidylinositols/*metabolism Signal Transduction/physiology Yeasts/metabolism
196-202
Jones, D. R.
fcbc07f0-6ce7-4ea0-b8b3-f0e6a9581279
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
1 April 2004
Jones, D. R.
fcbc07f0-6ce7-4ea0-b8b3-f0e6a9581279
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Jones, D. R. and Divecha, N.
(2004)
Linking lipids to chromatin.
Current Opinion in Genetics & Development, 14 (2), .
(doi:10.1016/j.gde.2004.02.003).
Abstract
Dynamic regulation of chromatin structure is thought to be a prerequisite for nuclear functions that require accessibility to DNA such as replication, transcription and DNA repair. The phosphoinositide (PI) pathway is a second messenger signalling system regulated in response to a variety of extracellular (growth factors, differentiation signals) and intracellular (cell cycle progression, DNA damage) stimuli. The presence of a PI pathway in the nucleus together with the recent findings that specific nuclear proteins can interact with and are regulated by phosphoinositides suggest that changes in the nuclear phosphoinositide profile may have a direct role in modulating chromatin structure.
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Published date: 1 April 2004
Additional Information:
Jones, David R Divecha, Nullin eng Research Support, Non-U.S. Gov't Review England 2004/06/16 Curr Opin Genet Dev. 2004 Apr;14(2):196-202. doi: 10.1016/j.gde.2004.02.003.
Keywords:
Chromatin/*metabolism Chromatin Assembly and Disassembly/*physiology Humans Phosphatidylinositol Phosphates/metabolism Phosphatidylinositols/*metabolism Signal Transduction/physiology Yeasts/metabolism
Identifiers
Local EPrints ID: 480082
URI: http://eprints.soton.ac.uk/id/eprint/480082
ISSN: 0959-437X
PURE UUID: 9cc10e1c-e654-40b2-99b4-9f3802b45c7b
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Date deposited: 01 Aug 2023 16:45
Last modified: 17 Mar 2024 02:59
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Author:
D. R. Jones
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