Inositides and the nucleus and inositides in the nucleus

Divecha, N., Banfic, H. and Irvine, R. F. (1993) Inositides and the nucleus and inositides in the nucleus. Cell, 74 (3), 405-407. (doi:10.1016/0092-8674(93)80041-c).

Abstract

Although there are many forms of evidence linking phosphoinositides to nuclear function, the substance of the links remains largely undefined. One link between inositide metabolism and the nucleus is suggested by the implication of inositol trisphosphate (IP3) in the process of nuclear envelope reassembly (Sullivan et al., 1993). That paper will be discussed below in its context, but this review will principally focus on another nuclear-inositide connection - a potential inositide cycle in the nucleus. It comes as something of a shock to see data that point to a phosphoinositide cycle entirely separate from the familiar one in the plasma membrane. Again contrary to expectation, the data suggest that the cycle is not in the nuclear membrane but appears to be within the nucleus. This aspect of inositide function has profound implications for the role of inositides in cell division and growth. For example, it makes us rethink the tumor-promoting actions of phorbol esters and the teratogenic effects of Li÷ that have been associated with inositide homeostasis. In this article the evidence of a nuclear inositide cycle and what is known about its control are reviewed, and the role it may play in eukaryotic cell function is discussed. For a discussion of proposed nuclear functions for protein kinase C and what little is known about nuclear Ca2÷, the reader is referred to a more comprehensive recent review (Irvine and Divecha, 1992).

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