Lipid kinases: charging PtdIns(4,5)P2 synthesis
Lipid kinases: charging PtdIns(4,5)P2 synthesis
Phosphatidylinositol (4,5) bisphosphate is a lipid second messenger that controls diverse cellular processes. Phosphatidylinositolphosphate-5-kinases synthesise this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is controlled. A recent study suggests that the intrinsic surface charge of the plasma membrane may be an important factor.
Cell Membrane/*metabolism Phagocytosis/*physiology Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates/*biosynthesis Phosphotransferases (Alcohol Group Acceptor)/*metabolism Second Messenger Systems/*physiology Static Electricity
R154-7
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
23 February 2010
Divecha, N.
5c2ad0f8-4ce7-405f-8a15-2fc4ab96d787
Abstract
Phosphatidylinositol (4,5) bisphosphate is a lipid second messenger that controls diverse cellular processes. Phosphatidylinositolphosphate-5-kinases synthesise this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is controlled. A recent study suggests that the intrinsic surface charge of the plasma membrane may be an important factor.
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Published date: 23 February 2010
Additional Information:
Divecha, Nullin eng Review England 2010/02/25 Curr Biol. 2010 Feb 23;20(4):R154-7. doi: 10.1016/j.cub.2010.01.016.
Keywords:
Cell Membrane/*metabolism Phagocytosis/*physiology Phosphatidylinositol 4,5-Diphosphate Phosphatidylinositol Phosphates/*biosynthesis Phosphotransferases (Alcohol Group Acceptor)/*metabolism Second Messenger Systems/*physiology Static Electricity
Identifiers
Local EPrints ID: 480188
URI: http://eprints.soton.ac.uk/id/eprint/480188
ISSN: 1879-0445
PURE UUID: 8467b381-37d2-4a91-91ec-1bb6899aff20
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Date deposited: 01 Aug 2023 17:00
Last modified: 17 Mar 2024 02:59
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