Proteinuria and progressive renal disease: birth weight and microalbuminuria
Proteinuria and progressive renal disease: birth weight and microalbuminuria
BACKGROUND: Microalbuminuria and nephropathy in diabetic subjects has been linked to low birth weight or short stature in adulthood. We have explored the relationship of foetal growth and intrauterine starvation with microalbuminuria in non-diabetic subjects.
METHODS: Albumin excretion rate was measured in an overnight sample in 236 men and women in Preston whose birth anthropometry had been recorded at the local maternity hospital. Albumin excretion rate was also measured in a 2-h and overnight sample in 98 subjects exposed to intrauterine maternal starvation during the Siege of Leningrad as well as in 124 subjects exposed in infancy and 62 born concurrently outside the Siege limits.
RESULTS: In 236 men and women aged 46-54 years in Preston, 11 had microalbuminuria on an overnight urine collection. There were trends for these subjects to have lower birth weight (105.8 oz vs. 112.9 oz, P = 0.20) and lower ponderal index at birth (12.3 oz/in3 x 1000 vs. 13.4 oz/in3 x 1000, P = 0.09) than those who were normoalbuminuric. The albumin excretion rate of the subjects exposed in utero to maternal starvation (daytime sample 5.2 x/divided by 2.8 micrograms.min-1; overnight sample 2.9 x/divided by 2.5 micrograms.min-1) was not significantly different from those of the subjects exposed in infancy (5.5 x/divided by 2.7 micrograms.min-1 and 3.3 x/divided by 2.5 micrograms.min-1, respectively) or from those who were unexposed (5.1 x/divided by 3.0 micrograms.min-1 and 3.2 x/divided by 2.2 micrograms x min-1, respectively), (P = 0.99 for daytime and P = 0.73 for overnight rates controlling for sex, BMI, and systolic blood pressure).
CONCLUSIONS: Consistent relationships of short stature with microalbuminuria and nephropathy in non-diabetic and diabetic subjects might suggest that more subtle anthropometric indices could relate to low nephron number at birth, or that postnatal or genetic influences could underlie the observed link.
Albuminuria/complications, Birth Weight, Disease Progression, Embryonic and Fetal Development, Female, Fetus/physiology, Humans, Kidney Diseases/complications, Male, Middle Aged, Nutritional Status, Pregnancy, Pregnancy Complications, Proteinuria/complications, Starvation/complications
10-3
Yudkin, J S
a0b1ae7c-c872-4143-82a7-8007bd6bdb41
Phillips, D I
9999aedb-22c8-409f-bc87-43f469cf2596
Stanner, S
aad93c41-2b50-4768-9afb-8b62413e3cda
15 December 1997
Yudkin, J S
a0b1ae7c-c872-4143-82a7-8007bd6bdb41
Phillips, D I
9999aedb-22c8-409f-bc87-43f469cf2596
Stanner, S
aad93c41-2b50-4768-9afb-8b62413e3cda
Yudkin, J S, Phillips, D I and Stanner, S
(1997)
Proteinuria and progressive renal disease: birth weight and microalbuminuria.
Nephrology Dialysis Transplantation, 12 (S2), .
Abstract
BACKGROUND: Microalbuminuria and nephropathy in diabetic subjects has been linked to low birth weight or short stature in adulthood. We have explored the relationship of foetal growth and intrauterine starvation with microalbuminuria in non-diabetic subjects.
METHODS: Albumin excretion rate was measured in an overnight sample in 236 men and women in Preston whose birth anthropometry had been recorded at the local maternity hospital. Albumin excretion rate was also measured in a 2-h and overnight sample in 98 subjects exposed to intrauterine maternal starvation during the Siege of Leningrad as well as in 124 subjects exposed in infancy and 62 born concurrently outside the Siege limits.
RESULTS: In 236 men and women aged 46-54 years in Preston, 11 had microalbuminuria on an overnight urine collection. There were trends for these subjects to have lower birth weight (105.8 oz vs. 112.9 oz, P = 0.20) and lower ponderal index at birth (12.3 oz/in3 x 1000 vs. 13.4 oz/in3 x 1000, P = 0.09) than those who were normoalbuminuric. The albumin excretion rate of the subjects exposed in utero to maternal starvation (daytime sample 5.2 x/divided by 2.8 micrograms.min-1; overnight sample 2.9 x/divided by 2.5 micrograms.min-1) was not significantly different from those of the subjects exposed in infancy (5.5 x/divided by 2.7 micrograms.min-1 and 3.3 x/divided by 2.5 micrograms.min-1, respectively) or from those who were unexposed (5.1 x/divided by 3.0 micrograms.min-1 and 3.2 x/divided by 2.2 micrograms x min-1, respectively), (P = 0.99 for daytime and P = 0.73 for overnight rates controlling for sex, BMI, and systolic blood pressure).
CONCLUSIONS: Consistent relationships of short stature with microalbuminuria and nephropathy in non-diabetic and diabetic subjects might suggest that more subtle anthropometric indices could relate to low nephron number at birth, or that postnatal or genetic influences could underlie the observed link.
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Published date: 15 December 1997
Keywords:
Albuminuria/complications, Birth Weight, Disease Progression, Embryonic and Fetal Development, Female, Fetus/physiology, Humans, Kidney Diseases/complications, Male, Middle Aged, Nutritional Status, Pregnancy, Pregnancy Complications, Proteinuria/complications, Starvation/complications
Identifiers
Local EPrints ID: 480384
URI: http://eprints.soton.ac.uk/id/eprint/480384
ISSN: 0931-0509
PURE UUID: 6bff6f00-79b5-45d6-a6f0-16119d2d3521
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Date deposited: 01 Aug 2023 20:18
Last modified: 01 Aug 2023 20:18
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Author:
J S Yudkin
Author:
D I Phillips
Author:
S Stanner
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