Association of longer leukocyte telomere length with cardiac size, function, and heart failure
Association of longer leukocyte telomere length with cardiac size, function, and heart failure
Importance: longer leukocyte telomere length (LTL) is associated with a lower risk of adverse cardiovascular outcomes. The extent to which variation in LTL is associated with intermediary cardiovascular phenotypes is unclear.
Objective: to evaluate the associations between LTL and a diverse set of cardiovascular imaging phenotypes
Design, Setting, and Participants: this is a population-based cross-sectional study of UK Biobank participants recruited from 2006 to 2010. LTL was measured using a quantitative polymerase chain reaction method. Cardiovascular measurements were derived from cardiovascular magnetic resonance using machine learning. The median (IQR) duration of follow-up was 12.0 (11.3-12.7) years. The associations of LTL with imaging measurements and incident heart failure (HF) were evaluated by multivariable regression models. Genetic associations between LTL and significantly associated traits were investigated by mendelian randomization. Data were analyzed from January to May 2023.
Exposure: LTL.
Main Outcomes and Measures: cardiovascular imaging traits and HF.
Results: of 40 459 included participants, 19 529 (48.3%) were men, and the mean (SD) age was 55.1 (7.6) years. Longer LTL was independently associated with a pattern of positive cardiac remodeling (higher left ventricular mass, larger global ventricular size and volume, and higher ventricular and atrial stroke volumes) and a lower risk of incident HF (LTL fourth quartile vs first quartile: hazard ratio, 0.86; 95% CI, 0.81-0.91; P = 1.8 × 10−6). Mendelian randomization analysis suggested a potential causal association between LTL and left ventricular mass, global ventricular volume, and left ventricular stroke volume.
Conclusions and Relevance: in this cross-sectional study, longer LTL was associated with a larger heart with better cardiac function in middle age, which could potentially explain the observed lower risk of incident HF.
808-815
Aung, Nay
709b152d-e704-4fdc-b066-7eafaa643a0b
Wang, Qingning
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van Duijvenboden, Stefan
83c9a693-2d89-43fd-b5a1-cf7b1979efa3
Burns, Richard
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Stoma, Svetlana
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Raisi-Estabragh, Zahra
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Ahmet, Selda
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Allara, Elias
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Wood, Angela
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Di Angelantonio, Emanuele
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Danesh, John
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Munroe, Patricia B.
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Young, Alistair
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Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Codd, Veryan
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Nelson, Christopher P.
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Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Samani, Nilesh J
548b29ab-a422-4827-a9c6-5db0e6cf8ae6
26 July 2023
Aung, Nay
709b152d-e704-4fdc-b066-7eafaa643a0b
Wang, Qingning
f65fb117-c5fb-4c02-8bfa-8d1769854038
van Duijvenboden, Stefan
83c9a693-2d89-43fd-b5a1-cf7b1979efa3
Burns, Richard
a8d38083-05bd-4f5f-a9e4-ef5213f97c74
Stoma, Svetlana
2a368ba8-5b88-4548-8f25-75657327bee7
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Ahmet, Selda
41225d24-776f-4249-aa6d-fb391bbfae3f
Allara, Elias
6da74d5d-2cb7-4a2d-a483-2a77593fa9d2
Wood, Angela
797aaf86-157c-4cb6-89c6-e095928e6ba7
Di Angelantonio, Emanuele
40046c2c-dc6a-4232-aae1-eb971665a69a
Danesh, John
8804d59b-cb74-4150-8e95-3ccd81e51deb
Munroe, Patricia B.
44d23746-20cd-4572-860e-7350424cc031
Young, Alistair
16202b80-e848-474f-91f8-fbdfa34d61a1
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Codd, Veryan
18ed4108-1eb4-4702-bff1-468efae23aae
Nelson, Christopher P.
7354f6bf-5b2a-4670-a234-4bdd5cf8dcd6
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Samani, Nilesh J
548b29ab-a422-4827-a9c6-5db0e6cf8ae6
Aung, Nay, Wang, Qingning, van Duijvenboden, Stefan, Burns, Richard, Stoma, Svetlana, Raisi-Estabragh, Zahra, Ahmet, Selda, Allara, Elias, Wood, Angela, Di Angelantonio, Emanuele, Danesh, John, Munroe, Patricia B., Young, Alistair, Harvey, Nicholas C., Codd, Veryan, Nelson, Christopher P., Petersen, Steffen E. and Samani, Nilesh J
(2023)
Association of longer leukocyte telomere length with cardiac size, function, and heart failure.
JAMA Cardiology, 8 (9), .
(doi:10.1001/jamacardio.2023.2167).
Abstract
Importance: longer leukocyte telomere length (LTL) is associated with a lower risk of adverse cardiovascular outcomes. The extent to which variation in LTL is associated with intermediary cardiovascular phenotypes is unclear.
Objective: to evaluate the associations between LTL and a diverse set of cardiovascular imaging phenotypes
Design, Setting, and Participants: this is a population-based cross-sectional study of UK Biobank participants recruited from 2006 to 2010. LTL was measured using a quantitative polymerase chain reaction method. Cardiovascular measurements were derived from cardiovascular magnetic resonance using machine learning. The median (IQR) duration of follow-up was 12.0 (11.3-12.7) years. The associations of LTL with imaging measurements and incident heart failure (HF) were evaluated by multivariable regression models. Genetic associations between LTL and significantly associated traits were investigated by mendelian randomization. Data were analyzed from January to May 2023.
Exposure: LTL.
Main Outcomes and Measures: cardiovascular imaging traits and HF.
Results: of 40 459 included participants, 19 529 (48.3%) were men, and the mean (SD) age was 55.1 (7.6) years. Longer LTL was independently associated with a pattern of positive cardiac remodeling (higher left ventricular mass, larger global ventricular size and volume, and higher ventricular and atrial stroke volumes) and a lower risk of incident HF (LTL fourth quartile vs first quartile: hazard ratio, 0.86; 95% CI, 0.81-0.91; P = 1.8 × 10−6). Mendelian randomization analysis suggested a potential causal association between LTL and left ventricular mass, global ventricular volume, and left ventricular stroke volume.
Conclusions and Relevance: in this cross-sectional study, longer LTL was associated with a larger heart with better cardiac function in middle age, which could potentially explain the observed lower risk of incident HF.
Text
jamacardiology_aung_2023_oi_230032_1689092909.06174
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Accepted/In Press date: 31 May 2023
e-pub ahead of print date: 26 July 2023
Published date: 26 July 2023
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© 2023 American Medical Association. All rights reserved.
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Local EPrints ID: 480497
URI: http://eprints.soton.ac.uk/id/eprint/480497
ISSN: 2380-6583
PURE UUID: 884c5502-b967-44d4-aa0f-5da07589e417
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Date deposited: 03 Aug 2023 16:41
Last modified: 18 Mar 2024 02:59
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Contributors
Author:
Nay Aung
Author:
Qingning Wang
Author:
Stefan van Duijvenboden
Author:
Richard Burns
Author:
Svetlana Stoma
Author:
Zahra Raisi-Estabragh
Author:
Selda Ahmet
Author:
Elias Allara
Author:
Angela Wood
Author:
Emanuele Di Angelantonio
Author:
John Danesh
Author:
Patricia B. Munroe
Author:
Alistair Young
Author:
Veryan Codd
Author:
Christopher P. Nelson
Author:
Steffen E. Petersen
Author:
Nilesh J Samani
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