Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia
Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia
Preeclampsia (PE) is a pregnancy disorder that may be associated with inadequate maternal nutrition. Fatty acids are vital for placental and fetal growth. Fatty acid desaturases, key enzymes influencing the metabolism of polyunsaturated fatty acids, are reported to be associated with cardiometabolic risk. Any imbalance in the levels of omega-3 and omega-6 fatty acids can result in increased inflammatory response. The current study reports the levels of erythrocyte fatty acids and desaturase index across gestation in women who develop PE (n = 108) and compares them with non-PE women (n = 216). Maternal erythrocyte fatty acids were measured at 4 time points during pregnancy (i.e., 11–14, 18–22, 26–28 weeks and at delivery) using gas chromatography. Maternal total erythrocyte saturated fatty acids and omega-6/omega-3 fatty acid ratio was higher in the PE group as compared to the non-PE group at 11–14 weeks and 18–22 weeks respectively. Maternal Δ5 desaturase index was lower while Δ6 desaturase index was higher in the PE group at 11–14 and 18–22 weeks. Maternal stearoyl CoA desaturase-18 (SCD-18) index was lower at 11–14 weeks and at delivery. These changes were mainly observed in the early onset PE (EOP) group. Δ6 desaturase index at 11–14 weeks predicted the risk of EOP. Imbalance in fatty acid levels and desaturase indices predate the clinical diagnosis of PE, indicating their role in its pathophysiology. Measurement of fatty acids and desaturase indices in early pregnancy merits evaluation as predictors of risk of PE.
Desaturase activity, Fatty acids, LCPUFA, Metabolism, Preeclampsia
Godhamgaonkar, A.A.
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Wadhwani, N.S.
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Randhir, K.N.
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Selukar, S.S.
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Dalvi, S.
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Dangat, Kamini
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Wagh, G.N.
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Lalwani, Sanjay
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Chandiok, N.
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Kulkarni, B.
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Fall, Caroline
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Sachdev, H.
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Gupte, S.
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Joshi, S.R.
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September 2023
Godhamgaonkar, A.A.
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Wadhwani, N.S.
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Randhir, K.N.
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Selukar, S.S.
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Dalvi, S.
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Dangat, Kamini
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Wagh, G.N.
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Lalwani, Sanjay
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Chandiok, N.
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Kulkarni, B.
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Fall, Caroline
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Sachdev, H.
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Gupte, S.
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Joshi, S.R.
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Godhamgaonkar, A.A., Wadhwani, N.S., Randhir, K.N., Selukar, S.S., Dalvi, S., Dangat, Kamini, Wagh, G.N., Lalwani, Sanjay, Chandiok, N., Kulkarni, B., Fall, Caroline, Sachdev, H., Gupte, S. and Joshi, S.R.
(2023)
Erythrocyte fatty acids and desaturase indices in early pregnancy are associated with risk of preeclampsia.
Prostaglandins, Leukotrienes and Essential Fatty Acids, 196, [102583].
(doi:10.1016/j.plefa.2023.102583).
Abstract
Preeclampsia (PE) is a pregnancy disorder that may be associated with inadequate maternal nutrition. Fatty acids are vital for placental and fetal growth. Fatty acid desaturases, key enzymes influencing the metabolism of polyunsaturated fatty acids, are reported to be associated with cardiometabolic risk. Any imbalance in the levels of omega-3 and omega-6 fatty acids can result in increased inflammatory response. The current study reports the levels of erythrocyte fatty acids and desaturase index across gestation in women who develop PE (n = 108) and compares them with non-PE women (n = 216). Maternal erythrocyte fatty acids were measured at 4 time points during pregnancy (i.e., 11–14, 18–22, 26–28 weeks and at delivery) using gas chromatography. Maternal total erythrocyte saturated fatty acids and omega-6/omega-3 fatty acid ratio was higher in the PE group as compared to the non-PE group at 11–14 weeks and 18–22 weeks respectively. Maternal Δ5 desaturase index was lower while Δ6 desaturase index was higher in the PE group at 11–14 and 18–22 weeks. Maternal stearoyl CoA desaturase-18 (SCD-18) index was lower at 11–14 weeks and at delivery. These changes were mainly observed in the early onset PE (EOP) group. Δ6 desaturase index at 11–14 weeks predicted the risk of EOP. Imbalance in fatty acid levels and desaturase indices predate the clinical diagnosis of PE, indicating their role in its pathophysiology. Measurement of fatty acids and desaturase indices in early pregnancy merits evaluation as predictors of risk of PE.
Text
PLEFA Fatty Acid MSaccepted version PLEFA 2023
- Accepted Manuscript
More information
Accepted/In Press date: 20 July 2023
e-pub ahead of print date: 21 July 2023
Published date: September 2023
Additional Information:
Funding Information:
This study was supported by Indian Council of Medical Research , New Delhi, India (grant number: 5/7/1069/13-RCH , dated 31/03/2017).
Funding Information:
The current study is a part of an ongoing project funded by the Indian Council of Medical Research as a center of Advanced Research (ICMR-CAR) – “Investigating Mechanisms leading to Preeclampsia” at IRSHA, Bharati Vidyapeeth University, Pune (5/7/1069/13-RCH, dated 31–03–2017). The study protocol was approved by the Institutional Ethics Committee, Bharati Vidyapeeth Deemed University (IEC/2015/37, dated 03.10.2015). The subjects for this longitudinal study were recruited from two hospitals, Bharati Medical College and Hospital, and Gupte Hospital and Research center, Pune, Western India. Pregnant women visiting the hospital for their first antenatal visit were approached by the counselor and those who agreed to participate and were ready to deliver at the above hospitals were recruited in the study and followed up throughout their gestation till delivery. Written informed consent was obtained from the women. Detailed information such as personal, obstetric, clinical and family history were recorded. The detailed study design and recruitment criteria has been discussed earlier [38] .
Publisher Copyright:
© 2023 Elsevier Ltd
Keywords:
Desaturase activity, Fatty acids, LCPUFA, Metabolism, Preeclampsia
Identifiers
Local EPrints ID: 480529
URI: http://eprints.soton.ac.uk/id/eprint/480529
ISSN: 0952-3278
PURE UUID: 421d3518-da98-40d0-a3eb-e98cfd9d3951
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Date deposited: 04 Aug 2023 16:32
Last modified: 20 Jul 2024 04:01
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Contributors
Author:
A.A. Godhamgaonkar
Author:
N.S. Wadhwani
Author:
K.N. Randhir
Author:
S.S. Selukar
Author:
S. Dalvi
Author:
Kamini Dangat
Author:
G.N. Wagh
Author:
Sanjay Lalwani
Author:
N. Chandiok
Author:
B. Kulkarni
Author:
H. Sachdev
Author:
S. Gupte
Author:
S.R. Joshi
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