Stable gold nanoflowers modified by zwitterionic sulfhydryl sulfobetaine for enhanced antitumor efficiency
Stable gold nanoflowers modified by zwitterionic sulfhydryl sulfobetaine for enhanced antitumor efficiency
Gold nanoflowers are flower-like gold nanoparticles with high photothermal conversion efficiency. Unfortunately, many gold nanoflowers have complicated synthesis methods using toxicity molecules and lack colloidal stability. In this work, in order to improve the long-term colloidal stability of existing gold nanoflowers, sulfhydryl sulfobetaine (SB-SH) was modified on the surface of gold nanoflowers by S-Au bonds to produce SB-SH stabilized gold nanoflowers (SB-SH@AuNFs). SB-SH@AuNFs did not generate any precipitation within 24 h and had a high photothermal conversion efficiency at 38.9%. In addition, the relative cell viability of A549 cells was only 11% with 0.193 mM SB-SH@AuNFs under laser irradiation. More importantly, SB-SH@AuNFs had the best antitumor effect in vivo under 808 nm laser irradiation. Thus, stable SB-SH@AuNFs with high photothermal conversion efficient were synthesized by using zwitterionic molecules. The modification of gold nanoflowers using zwitterionic molecules here is a new method to improve the antitumor efficiency of noble metal photothermal agents.
Antitumor, Cell viability, Gold nanoflowers, Photothermal therapy, Zwitterionic
Zhang, Bingjie
2a11a43b-3bec-4ca2-969a-c68248cf2737
Yu, Shuqian
48428451-0ada-4668-9caa-1577b279d16f
Zhou, Lijie
a5c74408-d554-4440-a477-e31a5b40da1a
Feng, Jingjing
d0c3b1d0-1636-4ad8-8336-62b683bd8eef
Xie, Danyang
c7a58071-8be8-4c2d-a55a-3625f0541d48
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
20 September 2023
Zhang, Bingjie
2a11a43b-3bec-4ca2-969a-c68248cf2737
Yu, Shuqian
48428451-0ada-4668-9caa-1577b279d16f
Zhou, Lijie
a5c74408-d554-4440-a477-e31a5b40da1a
Feng, Jingjing
d0c3b1d0-1636-4ad8-8336-62b683bd8eef
Xie, Danyang
c7a58071-8be8-4c2d-a55a-3625f0541d48
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Zhang, Bingjie, Yu, Shuqian, Zhou, Lijie, Feng, Jingjing, Xie, Danyang and Ma, Guanglong
(2023)
Stable gold nanoflowers modified by zwitterionic sulfhydryl sulfobetaine for enhanced antitumor efficiency.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 673, [131805].
(doi:10.1016/j.colsurfa.2023.131805).
Abstract
Gold nanoflowers are flower-like gold nanoparticles with high photothermal conversion efficiency. Unfortunately, many gold nanoflowers have complicated synthesis methods using toxicity molecules and lack colloidal stability. In this work, in order to improve the long-term colloidal stability of existing gold nanoflowers, sulfhydryl sulfobetaine (SB-SH) was modified on the surface of gold nanoflowers by S-Au bonds to produce SB-SH stabilized gold nanoflowers (SB-SH@AuNFs). SB-SH@AuNFs did not generate any precipitation within 24 h and had a high photothermal conversion efficiency at 38.9%. In addition, the relative cell viability of A549 cells was only 11% with 0.193 mM SB-SH@AuNFs under laser irradiation. More importantly, SB-SH@AuNFs had the best antitumor effect in vivo under 808 nm laser irradiation. Thus, stable SB-SH@AuNFs with high photothermal conversion efficient were synthesized by using zwitterionic molecules. The modification of gold nanoflowers using zwitterionic molecules here is a new method to improve the antitumor efficiency of noble metal photothermal agents.
Text
Stable_gold_nanoflowers_modified_by_zwitterionic_sulfhydryl_sulfobetaine_for_enhanced_antitumor_effiecieny
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Accepted/In Press date: 2 June 2023
e-pub ahead of print date: 3 June 2023
Published date: 20 September 2023
Additional Information:
Funding Information:
The authors appreciate financial support from Natural Science Foundation of Hebei Province ( B2017203229 ) and Subsidy for Hebei Key Laboratory of Applied Chemistry after Operation Performance ( 22567616H ).
Publisher Copyright:
© 2023 Elsevier B.V.
Keywords:
Antitumor, Cell viability, Gold nanoflowers, Photothermal therapy, Zwitterionic
Identifiers
Local EPrints ID: 480745
URI: http://eprints.soton.ac.uk/id/eprint/480745
ISSN: 0927-7757
PURE UUID: 62b08a62-8dea-419a-9af7-474b160caed3
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Date deposited: 09 Aug 2023 17:00
Last modified: 17 Mar 2024 04:00
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Contributors
Author:
Bingjie Zhang
Author:
Shuqian Yu
Author:
Lijie Zhou
Author:
Jingjing Feng
Author:
Danyang Xie
Author:
Guanglong Ma
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