Comparing cost-utility estimates: does the choice of EQ-5D or SF-6D matter?
Comparing cost-utility estimates: does the choice of EQ-5D or SF-6D matter?
Background: A number of different measures can be used within cost-utility analyses, we compared results according to both the EQ-5D and SF-6D.
Methods: A randomized trial was conducted to compare 4 options for people with knee pain. Over the 2 year trial period, the change in cost to health-service was estimated, and both the EQ-5D and SF-6D were used to estimate the change in quality-adjusted life years (QALYs). Using a complete case analysis, the cost-utility (incremental cost-effectiveness ratio [ICER]) of each option, according to both the EQ-5D and SF-6D, was calculated and assessed in relation to the cost-effectiveness threshold of pound20,000 per QALY.
Results: Of the 389 participants, 247 had complete cost, EQ-5D and SF-6D data. According to the EQ-5D, option 1 had an estimated ICER of pound10,815 (compared with option 4), option 2 was dominated by option 1, and option 3 was subject to extended dominance. Conversely, according to the SF-6D, option 3 had an ICER of pound9999 (compared with option 4), option 2 had an ICER of pound36,883 (compared with option 3), and option 1 was subject to extended dominance.
Conclusion: The EQ-5D and SF-6D estimated that different options (1 and 3, respectively) were cost-effective at the pound20,000 per QALY threshold, demonstrating that the choice of measure does matter.
Cost-Benefit Analysis, Health Status Indicators, Humans, Knee Joint, Pain/economics, Pain Management, Quality-Adjusted Life Years, Time Factors
889-94
Sach, Tracey H
5c09256f-ebed-4d14-853a-181f6c92d6f2
Barton, Garry R
bf3455b3-9bee-4af6-94e8-930b2a383b33
Jenkinson, Claire
3bf90b54-206f-4230-b44a-0c51a26cfa5b
Doherty, Michael
ab3e38b1-4e66-48b0-ae34-ec710c4fce2c
Avery, Anthony J
ba667df1-c7e8-4812-855c-8f5d8c37ed86
Muir, Kenneth R
4703d677-d4f5-4386-aa1e-2de40e31354f
1 August 2009
Sach, Tracey H
5c09256f-ebed-4d14-853a-181f6c92d6f2
Barton, Garry R
bf3455b3-9bee-4af6-94e8-930b2a383b33
Jenkinson, Claire
3bf90b54-206f-4230-b44a-0c51a26cfa5b
Doherty, Michael
ab3e38b1-4e66-48b0-ae34-ec710c4fce2c
Avery, Anthony J
ba667df1-c7e8-4812-855c-8f5d8c37ed86
Muir, Kenneth R
4703d677-d4f5-4386-aa1e-2de40e31354f
Sach, Tracey H, Barton, Garry R, Jenkinson, Claire, Doherty, Michael, Avery, Anthony J and Muir, Kenneth R
(2009)
Comparing cost-utility estimates: does the choice of EQ-5D or SF-6D matter?
Medical Care, 47 (8), .
(doi:10.1097/MLR.0b013e3181a39428).
Abstract
Background: A number of different measures can be used within cost-utility analyses, we compared results according to both the EQ-5D and SF-6D.
Methods: A randomized trial was conducted to compare 4 options for people with knee pain. Over the 2 year trial period, the change in cost to health-service was estimated, and both the EQ-5D and SF-6D were used to estimate the change in quality-adjusted life years (QALYs). Using a complete case analysis, the cost-utility (incremental cost-effectiveness ratio [ICER]) of each option, according to both the EQ-5D and SF-6D, was calculated and assessed in relation to the cost-effectiveness threshold of pound20,000 per QALY.
Results: Of the 389 participants, 247 had complete cost, EQ-5D and SF-6D data. According to the EQ-5D, option 1 had an estimated ICER of pound10,815 (compared with option 4), option 2 was dominated by option 1, and option 3 was subject to extended dominance. Conversely, according to the SF-6D, option 3 had an ICER of pound9999 (compared with option 4), option 2 had an ICER of pound36,883 (compared with option 3), and option 1 was subject to extended dominance.
Conclusion: The EQ-5D and SF-6D estimated that different options (1 and 3, respectively) were cost-effective at the pound20,000 per QALY threshold, demonstrating that the choice of measure does matter.
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Published date: 1 August 2009
Keywords:
Cost-Benefit Analysis, Health Status Indicators, Humans, Knee Joint, Pain/economics, Pain Management, Quality-Adjusted Life Years, Time Factors
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Local EPrints ID: 480799
URI: http://eprints.soton.ac.uk/id/eprint/480799
ISSN: 0025-7079
PURE UUID: 2f9636c4-de23-411e-b6da-7930b496d5aa
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Date deposited: 09 Aug 2023 17:14
Last modified: 17 Mar 2024 04:20
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Author:
Tracey H Sach
Author:
Garry R Barton
Author:
Claire Jenkinson
Author:
Michael Doherty
Author:
Anthony J Avery
Author:
Kenneth R Muir
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