Crystal structure and NMR of an α,δ-peptide foldamer helix shows side-chains are well placed for bifunctional catalysis: application as a minimalist aldolase mimic**

Accepted/In Press date: 23 May 2023

e-pub ahead of print date: 23 May 2023

Published date: 4 September 2023

Additional Information: Funding Information: We thank The Leverhulme Trust for funding from a Research Project Grant (RPG‐2019‐283), in addition to King's College London and the China Scholarship Council (Studentship to QL) as well as the Wellcome Trust and the Royal Society (Sir Henry Dale Fellowship to MM, 202250/Z/16/Z). In respect of periodic DFT calculations, we are grateful to the UK Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/T022213/1, EP/W032260/1 and EP/P020194/1). We also thank the EPSRC UK National Crystallography Service at the University of Southampton, and the University of Reading's Chemical Analysis Facility, for the collection of the crystallographic data. Hao Lan would like to thank the Bristol Chemical Synthesis CDT, funded by EPSRC (EP/L015366/1), for a PhD studentship. Finally, we thank Prof. Christina Redfield, the University of Oxford, for the help with using 950 MHz ultra‐high resolution NMR spectrometer. Funding Information: We thank The Leverhulme Trust for funding from a Research Project Grant (RPG-2019-283), in addition to King's College London and the China Scholarship Council (Studentship to QL) as well as the Wellcome Trust and the Royal Society (Sir Henry Dale Fellowship to MM, 202250/Z/16/Z). In respect of periodic DFT calculations, we are grateful to the UK Materials and Molecular Modelling Hub for computational resources, which is partially funded by EPSRC (EP/T022213/1, EP/W032260/1 and EP/P020194/1). We also thank the EPSRC UK National Crystallography Service at the University of Southampton, and the University of Reading's Chemical Analysis Facility, for the collection of the crystallographic data. Hao Lan would like to thank the Bristol Chemical Synthesis CDT, funded by EPSRC (EP/L015366/1), for a PhD studentship. Finally, we thank Prof. Christina Redfield, the University of Oxford, for the help with using 950 MHz ultra-high resolution NMR spectrometer. Publisher Copyright: © 2023 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.

Related URLs:

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Keywords: aldolase, catalysis, helical conformation, peptides, peptidic foldamers

Local EPrints ID: 480951

URI: http://eprints.soton.ac.uk/id/eprint/480951

DOI: doi:10.1002/anie.202305326

ISSN: 1433-7851

PURE UUID: fc3f9ea1-c2d4-4eca-9628-07c5b70ad598

ORCID for Peter N. Horton: orcid.org/0000-0001-8886-2016

Date deposited: 11 Aug 2023 16:56

Last modified: 06 Jun 2024 01:38