Monitoring neurodegenerative diseases using paper based lateral-flow devices
Monitoring neurodegenerative diseases using paper based lateral-flow devices
Alzheimer’s disease is caused by neurodegeneration resulting in cognitive decline, that has been linked to heightened systemic inflammation. Identification of the characteristic amyloid-β (Aβ) plaques in the brain is either by positron-emission tomography (PET) imaging or through its measurement in cerebrospinal fluid (CSF). A minimally invasive, cost-effective test that measures blood-based biomarker could predict the onset of Alzheimer’s earlier and therefore start therapies to improve patient prognosis. To this end, we have developed lateral-flow tests that measure vascular biomarkers, ICAM-1 and VCAM-1 and have validated their clinical use with serum samples.
Iles, Alice
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He, Peijun
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Katis, Ioannis
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Galanis, Panagiotis
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Sones, Collin
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Eason, R.W.
e38684c3-d18c-41b9-a4aa-def67283b020
7 May 2022
Iles, Alice
b0e82316-6070-4bda-8731-a1b6163a6d30
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
Galanis, Panagiotis
4457b788-deef-4293-ab39-76f501b9529d
Sones, Collin
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
Eason, R.W.
e38684c3-d18c-41b9-a4aa-def67283b020
Iles, Alice, He, Peijun, Katis, Ioannis, Galanis, Panagiotis, Sones, Collin and Eason, R.W.
(2022)
Monitoring neurodegenerative diseases using paper based lateral-flow devices.
In Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX.
SPIE..
(doi:10.1117/12.2603877).
Record type:
Conference or Workshop Item
(Paper)
Abstract
Alzheimer’s disease is caused by neurodegeneration resulting in cognitive decline, that has been linked to heightened systemic inflammation. Identification of the characteristic amyloid-β (Aβ) plaques in the brain is either by positron-emission tomography (PET) imaging or through its measurement in cerebrospinal fluid (CSF). A minimally invasive, cost-effective test that measures blood-based biomarker could predict the onset of Alzheimer’s earlier and therefore start therapies to improve patient prognosis. To this end, we have developed lateral-flow tests that measure vascular biomarkers, ICAM-1 and VCAM-1 and have validated their clinical use with serum samples.
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Published date: 7 May 2022
Venue - Dates:
Photonics West 2022, 2022-01-22
Identifiers
Local EPrints ID: 481178
URI: http://eprints.soton.ac.uk/id/eprint/481178
ISSN: 0277-786X
PURE UUID: 089ac961-ddfd-4f4c-9aa7-4d9d63d150a2
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Date deposited: 17 Aug 2023 16:49
Last modified: 17 Mar 2024 03:35
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Author:
Alice Iles
Author:
Panagiotis Galanis
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