Optimisation of flow path parameters for enhanced sensitivity lateral flow
Optimisation of flow path parameters for enhanced sensitivity lateral flow
Lateral flow devices (LFDs) are widely used point-of-care (POC) diagnostics. The basic LFD design remains largely unchanged since their first development and this limits their use in clinical applications due to lack of sensitivity. To enhance this, we report the use of laser-patterned geometric control barriers, in the form of a constriction, that leads to a slower flow rate and smaller test zone area. This high sensitivity LFD (HS-LFD) achieved 62% increase in test line colour intensity for the detection of procalcitonin (PCT) and reduced the LOD from 10 ng/ml to 1 ng/ml with contrived human samples.
Iles, Alice
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Katis, Ioannis
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He, Peijun
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Galanis, Panagiotis
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Sones, Collin
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Eason, R.W.
e38684c3-d18c-41b9-a4aa-def67283b020
Iles, Alice
b0e82316-6070-4bda-8731-a1b6163a6d30
Katis, Ioannis
f92dfb8f-610d-4877-83f6-fd26a571df12
He, Peijun
2e303166-6aa5-4a09-b22e-440d96a54a9f
Galanis, Panagiotis
4457b788-deef-4293-ab39-76f501b9529d
Sones, Collin
9de9d8ee-d394-46a5-80b7-e341c0eed0a8
Eason, R.W.
e38684c3-d18c-41b9-a4aa-def67283b020
Iles, Alice, Katis, Ioannis, He, Peijun, Galanis, Panagiotis, Sones, Collin and Eason, R.W.
(2022)
Optimisation of flow path parameters for enhanced sensitivity lateral flow.
In Optical Diagnostics and Sensing XXII: Toward Point-of-Care Diagnostics.
SPIE..
(doi:10.1117/12.2603880).
Record type:
Conference or Workshop Item
(Paper)
Abstract
Lateral flow devices (LFDs) are widely used point-of-care (POC) diagnostics. The basic LFD design remains largely unchanged since their first development and this limits their use in clinical applications due to lack of sensitivity. To enhance this, we report the use of laser-patterned geometric control barriers, in the form of a constriction, that leads to a slower flow rate and smaller test zone area. This high sensitivity LFD (HS-LFD) achieved 62% increase in test line colour intensity for the detection of procalcitonin (PCT) and reduced the LOD from 10 ng/ml to 1 ng/ml with contrived human samples.
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e-pub ahead of print date: 12 May 2022
Venue - Dates:
Photonics West 2022, 2022-01-22
Identifiers
Local EPrints ID: 481180
URI: http://eprints.soton.ac.uk/id/eprint/481180
ISSN: 0277-786X
PURE UUID: ff39e8d5-e5fe-46f7-afb7-485e928a7093
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Date deposited: 17 Aug 2023 16:50
Last modified: 17 Mar 2024 03:35
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Contributors
Author:
Alice Iles
Author:
Panagiotis Galanis
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