Asthma innovations from the first International Collaborative Asthma Network forum
Asthma innovations from the first International Collaborative Asthma Network forum
BACKGROUND: Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on type 2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 and immunity. An international group of investigators developed the International Collaborative Asthma Network (ICAN) with the goal of sharing innovative research on disease mechanisms, developing new technologies and therapies, organising pilot studies and engaging early-stage career investigators from across the world. This report describes the purpose, development and outcomes of the first ICAN forum.
METHODS: Abstracts were solicited from interdisciplinary early-stage career investigators with innovative ideas beyond T2 inflammation for asthma and were selected for presentation at the forum. Breakout sessions were conducted to discuss innovation, collaboration and research translation.
RESULTS: The abstracts were categorised into: 1) general omics and big data analysis; 2) lung-brain axis and airway neurology; 3) sex differences; 4) paediatric asthma; 5) new therapeutic targets inspired by airway epithelial biology; 6) new therapeutics targeting airway and circulating immune mediators; and 7) lung anatomy, physiology and imaging. Discussions revealed that research groups are looking for opportunities to further their findings using larger scale collaboration and the ability to translate their in vitro findings into clinical treatment.
CONCLUSIONS: Through ICAN, teams that included interdisciplinary early-stage career investigators discussed innovation, collaboration and translation in asthma and severe asthma research. With a combination of fresh ideas and energetic, collaborative, global participation, ICAN has laid a firm foundation and model for future collaborative global asthma research.
Gaston, Benjamin
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Gardner, Donna D
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Mahan, Kenzie
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Akuthota, Praveen
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Mendonca, Eneida A
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Durrington, Hannah
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Marozkina, Nadzeya
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Martinez-Nunez, Rocio T
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Newcomb, Dawn
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Ainsworth, Benjamin
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Owora, Arthur H
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Chung, Kian Fan
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Walker, Samantha
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Fowler, Stephen J
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Siddiqui, Salman
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Winders, Tonya
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Zein, Joe
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Jarjour, Nizar
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Huang, Yvonne J
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Cahill, Katherine N
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Djukanovic, Ratko
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30 May 2023
Gaston, Benjamin
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Gardner, Donna D
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Mahan, Kenzie
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Akuthota, Praveen
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Mendonca, Eneida A
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Durrington, Hannah
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Marozkina, Nadzeya
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Martinez-Nunez, Rocio T
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Newcomb, Dawn
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Ainsworth, Benjamin
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Owora, Arthur H
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Chung, Kian Fan
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Walker, Samantha
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Fowler, Stephen J
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Siddiqui, Salman
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Winders, Tonya
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Zein, Joe
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Jarjour, Nizar
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Huang, Yvonne J
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Cahill, Katherine N
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Djukanovic, Ratko
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Gaston, Benjamin, Gardner, Donna D, Mahan, Kenzie, Akuthota, Praveen, Mendonca, Eneida A, Durrington, Hannah, Marozkina, Nadzeya, Martinez-Nunez, Rocio T, Newcomb, Dawn, Ainsworth, Benjamin, Owora, Arthur H, Chung, Kian Fan, Walker, Samantha, Fowler, Stephen J, Siddiqui, Salman, Winders, Tonya, Zein, Joe, Jarjour, Nizar, Huang, Yvonne J, Cahill, Katherine N and Djukanovic, Ratko
(2023)
Asthma innovations from the first International Collaborative Asthma Network forum.
ERJ Open Research, 9 (3), [00090-2023].
(doi:10.1183/23120541.00090-2023).
Abstract
BACKGROUND: Many patients have uncontrolled asthma despite available treatments. Most of the new asthma therapies have focused on type 2 (T2) inflammation, leaving an unmet need for innovative research into mechanisms of asthma beyond T2 and immunity. An international group of investigators developed the International Collaborative Asthma Network (ICAN) with the goal of sharing innovative research on disease mechanisms, developing new technologies and therapies, organising pilot studies and engaging early-stage career investigators from across the world. This report describes the purpose, development and outcomes of the first ICAN forum.
METHODS: Abstracts were solicited from interdisciplinary early-stage career investigators with innovative ideas beyond T2 inflammation for asthma and were selected for presentation at the forum. Breakout sessions were conducted to discuss innovation, collaboration and research translation.
RESULTS: The abstracts were categorised into: 1) general omics and big data analysis; 2) lung-brain axis and airway neurology; 3) sex differences; 4) paediatric asthma; 5) new therapeutic targets inspired by airway epithelial biology; 6) new therapeutics targeting airway and circulating immune mediators; and 7) lung anatomy, physiology and imaging. Discussions revealed that research groups are looking for opportunities to further their findings using larger scale collaboration and the ability to translate their in vitro findings into clinical treatment.
CONCLUSIONS: Through ICAN, teams that included interdisciplinary early-stage career investigators discussed innovation, collaboration and translation in asthma and severe asthma research. With a combination of fresh ideas and energetic, collaborative, global participation, ICAN has laid a firm foundation and model for future collaborative global asthma research.
Text
00090-2023.full
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Accepted/In Press date: 30 May 2023
e-pub ahead of print date: 30 May 2023
Published date: 30 May 2023
Additional Information:
Funding Information:
Support statement: Early exploratory meetings at the American Thoracic Society Conference and European Respiratory Society International Congress were organised and funded by Asthma+Lung UK. The ICAN meeting was funded by the Allergy and Asthma Network, and with grants received from AstraZeneca, Zephryx and the National Heart Lung and Blood Institute (R13 HL156425). Additional support was from NHLBI P01 HL128192 (to B. Gaston) and P01 HL158507 (to B. Gaston). Medical writing and editorial support were provided by Erin P. Scott of Scott Medical Communications. This support was funded by the Allergy and Asthma Network. Funding information for this article has been deposited with the Crossref Funder Registry.
Publisher Copyright:
© The authors 2023.
Identifiers
Local EPrints ID: 481190
URI: http://eprints.soton.ac.uk/id/eprint/481190
ISSN: 2312-0541
PURE UUID: 06af2e42-6f61-44db-9774-5e0cdcd85988
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Date deposited: 17 Aug 2023 17:01
Last modified: 18 Mar 2024 03:13
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Contributors
Author:
Benjamin Gaston
Author:
Donna D Gardner
Author:
Kenzie Mahan
Author:
Praveen Akuthota
Author:
Eneida A Mendonca
Author:
Hannah Durrington
Author:
Nadzeya Marozkina
Author:
Rocio T Martinez-Nunez
Author:
Dawn Newcomb
Author:
Benjamin Ainsworth
Author:
Arthur H Owora
Author:
Kian Fan Chung
Author:
Samantha Walker
Author:
Stephen J Fowler
Author:
Salman Siddiqui
Author:
Tonya Winders
Author:
Joe Zein
Author:
Nizar Jarjour
Author:
Yvonne J Huang
Author:
Katherine N Cahill
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