Probing phospholipid dynamics by electrospray ionisation mass spectrometry
Probing phospholipid dynamics by electrospray ionisation mass spectrometry
Recent advances in electrospray ionisation mass spectrometry (ESI-MS) have greatly facilitated the analysis of phospholipid molecular species in a growing diversity of biological and clinical settings. The combination of ESI-MS and metabolic labelling employing substrates labelled with stable isotopes is especially exciting, permitting studies of phospholipid synthesis and turnover in vivo. This review will first describe the methodology involved and will then detail dynamic lipidomic studies that have applied the stable isotope incorporation approach. Finally, it will summarise the increasing number of studies that have used ESI-MS to characterise structural and signalling phospholipid molecular species in development and disease.
phospholipid molecular species, electrospray ionisation mass spectrometry, stable isotopes, phospholipid synthesis, disease
200-224
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Wilton, David C.
4b995f66-ad6c-4d96-9179-c64f3b54466a
Hunt, Alan N.
95a3e223-da96-40e7-b47d-27dce014e305
Attard, George S.
3219075d-2364-4f00-aeb9-1d90f8cd0d36
May 2007
Postle, Anthony D.
0fa17988-b4a0-4cdc-819a-9ae15c5dad66
Wilton, David C.
4b995f66-ad6c-4d96-9179-c64f3b54466a
Hunt, Alan N.
95a3e223-da96-40e7-b47d-27dce014e305
Attard, George S.
3219075d-2364-4f00-aeb9-1d90f8cd0d36
Postle, Anthony D., Wilton, David C., Hunt, Alan N. and Attard, George S.
(2007)
Probing phospholipid dynamics by electrospray ionisation mass spectrometry.
Progress in Lipid Research, 46 (3-4), .
(doi:10.1016/j.plipres.2007.04.001).
Abstract
Recent advances in electrospray ionisation mass spectrometry (ESI-MS) have greatly facilitated the analysis of phospholipid molecular species in a growing diversity of biological and clinical settings. The combination of ESI-MS and metabolic labelling employing substrates labelled with stable isotopes is especially exciting, permitting studies of phospholipid synthesis and turnover in vivo. This review will first describe the methodology involved and will then detail dynamic lipidomic studies that have applied the stable isotope incorporation approach. Finally, it will summarise the increasing number of studies that have used ESI-MS to characterise structural and signalling phospholipid molecular species in development and disease.
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Published date: May 2007
Keywords:
phospholipid molecular species, electrospray ionisation mass spectrometry, stable isotopes, phospholipid synthesis, disease
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Local EPrints ID: 48151
URI: http://eprints.soton.ac.uk/id/eprint/48151
ISSN: 0163-7827
PURE UUID: e3f9ef4a-3e65-4e7b-b2e3-b82c8cc08b48
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Date deposited: 30 Aug 2007
Last modified: 16 Mar 2024 02:48
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Author:
Alan N. Hunt
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