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Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research
Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research

Following on from the NASA twins' study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.

Genomics, Proteomics, Space medicine, Space sciences
2589-0042
107289
Manzano, Aránzazu
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Weging, Silvio
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Bezdan, Daniela
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Borg, Joseph
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Cahill, Thomas
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Carnero-Diaz, Eugénie
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Cope, Henry
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Deane, Colleen S.
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Etheridge, Timothy
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Giacomello, Stefania
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Hardiman, Gary
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Leys, Natalie
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Madrigal, Pedro
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Mastroleo, Felice
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Medina, F. Javier
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Mieczkowski, Jakub
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Fernandez-Rojo, Manuel A.
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Siew, Keith
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Szewczyk, Nathaniel J.
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Walsh, Stephen B.
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da Silveira, Willian A.
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Herranz, Raúl
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Manzano, Aránzazu
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Weging, Silvio
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Bezdan, Daniela
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Borg, Joseph
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Cahill, Thomas
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Carnero-Diaz, Eugénie
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Cope, Henry
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Deane, Colleen S.
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Etheridge, Timothy
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Giacomello, Stefania
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Hardiman, Gary
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Leys, Natalie
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Madrigal, Pedro
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Mastroleo, Felice
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Medina, F. Javier
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Mieczkowski, Jakub
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Fernandez-Rojo, Manuel A.
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Siew, Keith
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Szewczyk, Nathaniel J.
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Walsh, Stephen B.
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da Silveira, Willian A.
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Herranz, Raúl
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Manzano, Aránzazu, Weging, Silvio, Bezdan, Daniela, Borg, Joseph, Cahill, Thomas, Carnero-Diaz, Eugénie, Cope, Henry, Deane, Colleen S., Etheridge, Timothy, Giacomello, Stefania, Hardiman, Gary, Leys, Natalie, Madrigal, Pedro, Mastroleo, Felice, Medina, F. Javier, Mieczkowski, Jakub, Fernandez-Rojo, Manuel A., Siew, Keith, Szewczyk, Nathaniel J., Walsh, Stephen B., da Silveira, Willian A. and Herranz, Raúl (2023) Enhancing European capabilities for application of multi-omics studies in biology and biomedicine space research. iScience, 26 (9), 107289, [107289]. (doi:10.1016/j.isci.2023.107289).

Record type: Review

Abstract

Following on from the NASA twins' study, there has been a tremendous interest in the use of omics techniques in spaceflight. Individual space agencies, NASA's GeneLab, JAXA's ibSLS, and the ESA-funded Space Omics Topical Team and the International Standards for Space Omics Processing (ISSOP) groups have established several initiatives to support this growth. Here, we present recommendations from the Space Omics Topical Team to promote standard application of space omics in Europe. We focus on four main themes: i) continued participation in and coordination with international omics endeavors, ii) strengthening of the European space omics infrastructure including workforce and facilities, iii) capitalizing on the emerging opportunities in the commercial space sector, and iv) capitalizing on the emerging opportunities in human subjects research.

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e-pub ahead of print date: 12 July 2023
Published date: 15 September 2023
Additional Information: Funding Information: All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Horizon Center for Doctoral Training at the University of Nottingham [UKRI grant no. EP/S023305/1] to H.C. the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1] awarded to C.S.D.; the Spanish Comunidad Autonoma de Madrid TALENTO Modalidad-1 program project 2020-5A_BIO-19724 to M.A.F.R.; the Spanish National Research Council Grant 2021AEP135 to F.J.M. & R.H. the Swedish Research Council VR grant 2020-04864 to S.G. and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004, 2021-4800001117 to E.C.D. This research was also funded in part by the Wellcome Trust [110182/Z/15/Z] to K.S. N.J.S. acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O. Research Endowment in the Heritage College of Osteopathic Medicine. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Conceptualization and methodology, A.M. S.W. and R.H.; original draft preparation, A.M. S.W. and R.H.; subsection contributions, review, and editing, all authors; academic English review, C.S.D. K.S. and S.B.W.; project administration and editing, S.G. D.B. N.J.S. W.d.S. and R.H.; funding acquisition, R.H. All authors have read and agreed to the published version of the manuscript. F.M. is CEO/Co-Founder at Genegoggle, D.B. is a cofounder of Poppy Health, Inc. and CSO of Yuri Gravity GmbH and declares affiliations at the NGS Competence Center Tübingen (NCCT), University of Tübingen, Tübingen and Yuri Gravity, Meckenbeuren, Germany. M.F.R. declares additional affiliation at Diamantina Institute, The University of Queensland, St Lucia, Queensland 4072, Australia. S.G. is a scientific consultant of 10x Genomics. One or more of the authors of this paper self-identifies as an underrepresented ethnic minority in their field of research or within their geographical location. One or more of the authors of this paper self-identifies as a gender minority in their field of research. One or more of the authors of this paper self-identifies as a member of the LGBTQIA+ community. We avoided “helicopter science” practices by including the participating local contributors from the region where we conducted the research as authors on the paper. Funding Information: All listed authors are members of the ESA Space Omics Topical Team, funded by the ESA grant/contract 4000131202/20/NL/PG/pt “Space Omics: Toward an integrated ESA/NASA –omics database for spaceflight and ground facilities experiments” awarded to RH, which was the main funding source for this work. Individual authors also acknowledge support from: the Horizon Center for Doctoral Training at the University of Nottingham [ UKRI grant no. EP/S023305/1 ] to H.C., the Medical Research Council part of a Skills Development Fellowship [grant number MR/T026014/1 ] awarded to C.S.D.; the Spanish Comunidad Autonoma de Madrid TALENTO Modalidad-1 program project 2020-5A_BIO-19724 to M.A.F.R.; the Spanish National Research Council Grant 2021AEP135 to F.J.M. & R.H., the Swedish Research Council VR grant 2020-04864 to S.G. and the French Centre National d'Etudes Spatiales grant DAR 2020-4800001004 , 2021-4800001117 to E.C.D. This research was also funded in part by the Wellcome Trust [ 110182/Z/15/Z ] to K.S. N.J.S. acknowledges the support of the Osteopathic Heritage Foundation through funding for the Osteopathic Heritage Foundation Ralph S. Licklider, D.O., Research Endowment in the Heritage College of Osteopathic Medicine . For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from this submission. Publisher Copyright: © 2023 The Authors
Keywords: Genomics, Proteomics, Space medicine, Space sciences

Identifiers

Local EPrints ID: 481561
URI: http://eprints.soton.ac.uk/id/eprint/481561
ISSN: 2589-0042
PURE UUID: 5e548dbb-81ab-4795-8900-6183f69c0e76
ORCID for Colleen S. Deane: ORCID iD orcid.org/0000-0002-2281-6479

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Date deposited: 01 Sep 2023 17:11
Last modified: 13 Aug 2024 02:04

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Contributors

Author: Aránzazu Manzano
Author: Silvio Weging
Author: Daniela Bezdan
Author: Joseph Borg
Author: Thomas Cahill
Author: Eugénie Carnero-Diaz
Author: Henry Cope
Author: Colleen S. Deane ORCID iD
Author: Timothy Etheridge
Author: Stefania Giacomello
Author: Gary Hardiman
Author: Natalie Leys
Author: Pedro Madrigal
Author: Felice Mastroleo
Author: F. Javier Medina
Author: Jakub Mieczkowski
Author: Manuel A. Fernandez-Rojo
Author: Keith Siew
Author: Nathaniel J. Szewczyk
Author: Stephen B. Walsh
Author: Willian A. da Silveira
Author: Raúl Herranz

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