Enhanced particle self-ordering in a double-layer channel
Enhanced particle self-ordering in a double-layer channel
In this work, a novel double-layer microfluidic device for enhancing particle focusing was presented. The double-layer device consists of a channel with expansion-contraction array and periodical slanted grooves. The secondary flows induced by the grooves modulate the flow patterns in the expansion-contraction-array (ECA) channel, further affecting the particle migration. Compared with the single ECA channel, the double-layer channel can focus the particles over a wider range of flow rate. Due to the differentiation of lateral migration, the double-layer channel is able to distinguish the particles with different sizes. Furthermore, the equilibrium positions could be modulated by the orientation of grooves. This work demonstrates the possibility to enhance and adjust the inertial focusing in an ECA channel with the assistance of grooves, which may provide a simple and portable platform for downstream filtration, separation, and detection.
Double-layer channel, Fluid dynamics, Inertial microfluidics, Self-ordering
Yan, Sheng
1cf2968c-1639-4c47-a90b-481b86c441cb
Li, Yuxing
5e0dfa2f-1857-4c16-b79e-7becedb5eb55
Zhao, Qianbin
4e956b7f-4fb6-42fa-9a3b-b9a7c3703493
Yuan, Dan
76b9b77e-dda5-4682-8db0-75bfad1d1258
Yun, Guolin
240c3dc9-c224-41c0-8740-de165d1eb90b
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Li, Weihua
e2555036-0e48-425a-afeb-db6ffba5238e
1 June 2018
Yan, Sheng
1cf2968c-1639-4c47-a90b-481b86c441cb
Li, Yuxing
5e0dfa2f-1857-4c16-b79e-7becedb5eb55
Zhao, Qianbin
4e956b7f-4fb6-42fa-9a3b-b9a7c3703493
Yuan, Dan
76b9b77e-dda5-4682-8db0-75bfad1d1258
Yun, Guolin
240c3dc9-c224-41c0-8740-de165d1eb90b
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Li, Weihua
e2555036-0e48-425a-afeb-db6ffba5238e
Yan, Sheng, Li, Yuxing, Zhao, Qianbin, Yuan, Dan, Yun, Guolin, Tang, Shi Yang and Li, Weihua
(2018)
Enhanced particle self-ordering in a double-layer channel.
Biomedical Microdevices, 20 (2), [23].
(doi:10.1007/s10544-018-0269-5).
Abstract
In this work, a novel double-layer microfluidic device for enhancing particle focusing was presented. The double-layer device consists of a channel with expansion-contraction array and periodical slanted grooves. The secondary flows induced by the grooves modulate the flow patterns in the expansion-contraction-array (ECA) channel, further affecting the particle migration. Compared with the single ECA channel, the double-layer channel can focus the particles over a wider range of flow rate. Due to the differentiation of lateral migration, the double-layer channel is able to distinguish the particles with different sizes. Furthermore, the equilibrium positions could be modulated by the orientation of grooves. This work demonstrates the possibility to enhance and adjust the inertial focusing in an ECA channel with the assistance of grooves, which may provide a simple and portable platform for downstream filtration, separation, and detection.
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Published date: 1 June 2018
Additional Information:
Funding Information:
Acknowledgments Dr. Sheng Yan is the recipient of the 2018 Endeavour Research Fellowship funded by the Australian Department of Education and Training. Dr. Shi-Yang Tang is the recipient of the Vice-Chancellor’s Postdoctoral Research Fellowship funded by the University of Wollongong.
Publisher Copyright:
© 2018, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords:
Double-layer channel, Fluid dynamics, Inertial microfluidics, Self-ordering
Identifiers
Local EPrints ID: 481694
URI: http://eprints.soton.ac.uk/id/eprint/481694
ISSN: 1387-2176
PURE UUID: fd9a8ab1-f752-4cfe-be45-be7e4d05a94e
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Date deposited: 06 Sep 2023 16:48
Last modified: 18 Mar 2024 04:13
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Contributors
Author:
Sheng Yan
Author:
Yuxing Li
Author:
Qianbin Zhao
Author:
Dan Yuan
Author:
Guolin Yun
Author:
Shi Yang Tang
Author:
Weihua Li
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