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Tunable particle separation in a hybrid dielectrophoresis (DEP)- inertial microfluidic device

Tunable particle separation in a hybrid dielectrophoresis (DEP)- inertial microfluidic device
Tunable particle separation in a hybrid dielectrophoresis (DEP)- inertial microfluidic device

Particle separation is indispensable in many microfluidic systems and holds a broad range of biomedical applications. Inertial microfluidic devices that work solely on intrinsic hydrodynamic forces and inertial effects can offer label-free, high throughput and high efficiency separation performance. However, the working range of the current inertial microfluidic systems is obtained by tailoring the inertial lift forces and secondary flow drag through flow speed. Each channel design is normally effective for specific target particles, which inevitably lacks the flexibility for various particle mixtures. Redesigning the structure and dimension of microchannels for new sets of particle mixtures is often time-consuming and expensive. In this work, by introducing an external dielectrophoretic force field and coupling it with inertial forces, we proposed here an innovative hybrid DEP-inertial microfluidic platform for particle tunable separation. The working principle of the device was explained and its functionality was validated by experiments. In addition, the dimension of target particle mixture can be varied by adjusting the electrical voltage without redesigning the channel structure or dimensions. It is expected that the proposed DEP-inertial concept can work as a flexible platform for a wide range of biomedical applications.

Dielectrophoresis (DEP), Hybrid microfluidics, Inertial microfluidics, Particle separation
0925-4005
14-25
Zhang, Jun
a4628c00-1e1c-4729-8d8a-e7619a2c1edf
Yuan, Dan
76b9b77e-dda5-4682-8db0-75bfad1d1258
Zhao, Qianbin
4e956b7f-4fb6-42fa-9a3b-b9a7c3703493
Yan, Sheng
1cf2968c-1639-4c47-a90b-481b86c441cb
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Tan, Say Hwa
de336252-0c2c-4d54-acb9-46a4a37a6ec6
Guo, Jinhong
d65d7044-32c8-4028-a6b3-d221ad8bf006
Xia, Huanming
f9e8819e-2dde-4116-acce-02769c67e61a
Nguyen, Nam Trung
1c8ed53f-30d6-4de0-bdd6-e1693d360763
Li, Weihua
e2555036-0e48-425a-afeb-db6ffba5238e
Zhang, Jun
a4628c00-1e1c-4729-8d8a-e7619a2c1edf
Yuan, Dan
76b9b77e-dda5-4682-8db0-75bfad1d1258
Zhao, Qianbin
4e956b7f-4fb6-42fa-9a3b-b9a7c3703493
Yan, Sheng
1cf2968c-1639-4c47-a90b-481b86c441cb
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Tan, Say Hwa
de336252-0c2c-4d54-acb9-46a4a37a6ec6
Guo, Jinhong
d65d7044-32c8-4028-a6b3-d221ad8bf006
Xia, Huanming
f9e8819e-2dde-4116-acce-02769c67e61a
Nguyen, Nam Trung
1c8ed53f-30d6-4de0-bdd6-e1693d360763
Li, Weihua
e2555036-0e48-425a-afeb-db6ffba5238e

Zhang, Jun, Yuan, Dan, Zhao, Qianbin, Yan, Sheng, Tang, Shi Yang, Tan, Say Hwa, Guo, Jinhong, Xia, Huanming, Nguyen, Nam Trung and Li, Weihua (2018) Tunable particle separation in a hybrid dielectrophoresis (DEP)- inertial microfluidic device. Sensors and Actuators, B: Chemical, 267, 14-25. (doi:10.1016/j.snb.2018.04.020).

Record type: Article

Abstract

Particle separation is indispensable in many microfluidic systems and holds a broad range of biomedical applications. Inertial microfluidic devices that work solely on intrinsic hydrodynamic forces and inertial effects can offer label-free, high throughput and high efficiency separation performance. However, the working range of the current inertial microfluidic systems is obtained by tailoring the inertial lift forces and secondary flow drag through flow speed. Each channel design is normally effective for specific target particles, which inevitably lacks the flexibility for various particle mixtures. Redesigning the structure and dimension of microchannels for new sets of particle mixtures is often time-consuming and expensive. In this work, by introducing an external dielectrophoretic force field and coupling it with inertial forces, we proposed here an innovative hybrid DEP-inertial microfluidic platform for particle tunable separation. The working principle of the device was explained and its functionality was validated by experiments. In addition, the dimension of target particle mixture can be varied by adjusting the electrical voltage without redesigning the channel structure or dimensions. It is expected that the proposed DEP-inertial concept can work as a flexible platform for a wide range of biomedical applications.

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More information

Published date: 15 August 2018
Additional Information: Funding Information: J. Zhang greatly acknowledges the support from the National Natural Science Foundation of China (Grant No.51705257) and the Natural Science Foundation of Jiangsu Province (Grant No. BK20170839). N.T. Nguyen and W.H. Li acknowledge the support from the Australian Research Council (ARC) Discovery Project (Grant No. DP180100055). S.H Tan acknowledges the support from the Australian Research Council (ARC) DECRA fellowship (Grant No. DE170100600). Funding Information: J. Zhang greatly acknowledges the support from the National Natural Science Foundation of China (Grant No. 51705257 ) and the Natural Science Foundation of Jiangsu Province (Grant No. BK20170839 ). N.T. Nguyen and W.H. Li acknowledge the support from the Australian Research Council (ARC) Discovery Project (Grant No. DP180100055 ). S.H Tan acknowledges the support from the Australian Research Council (ARC) DECRA fellowship (Grant No. DE170100600 ). Publisher Copyright: © 2018 Elsevier B.V.
Keywords: Dielectrophoresis (DEP), Hybrid microfluidics, Inertial microfluidics, Particle separation

Identifiers

Local EPrints ID: 481702
URI: http://eprints.soton.ac.uk/id/eprint/481702
ISSN: 0925-4005
PURE UUID: e27c0a01-e9de-4078-8e2a-20faa9b50c9f
ORCID for Shi Yang Tang: ORCID iD orcid.org/0000-0002-3079-8880

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Date deposited: 06 Sep 2023 16:50
Last modified: 18 Mar 2024 04:13

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Contributors

Author: Jun Zhang
Author: Dan Yuan
Author: Qianbin Zhao
Author: Sheng Yan
Author: Shi Yang Tang ORCID iD
Author: Say Hwa Tan
Author: Jinhong Guo
Author: Huanming Xia
Author: Nam Trung Nguyen
Author: Weihua Li

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