Gallium-based liquid metal particles for therapeutics
Gallium-based liquid metal particles for therapeutics
Gallium (Ga) and Ga-based liquid metal (LM) alloys offer low toxicity, excellent electrical and thermal conductivities, and fluidity at or near room temperature. Ga-based LM particles (LMPs) synthesized from these LMs exhibit both fluidic and metallic properties and are suitable for versatile functionalization in therapeutics. Functionalized Ga-based LMPs can be actuated using physical or chemical stimuli for drug delivery, cancer treatment, bioimaging, and biosensing. However, many of the fundamentals of their unique characteristics for therapeutics remain underexplored. We present the most recent advances in Ga-based LMPs in therapeutics based on the underlying mechanisms of their design and implementation. We also highlight some future biotechnological opportunities for Ga-based LMPs based on their extraordinary advantages.
gallium, liquid metal particles, therapeutics
624-640
Xie, Wanjie
718129dc-cebc-4007-a495-a791960284d4
Allioux, Francois Marie
06fa4c1f-9d93-4fa4-bff6-2b4b4d497e95
Ou, Jian Zhen
80dec509-7411-417a-b56f-9d693b3510ca
Miyako, Eijiro
4b3c797a-d2b6-46a4-9f21-3bba058c82fe
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Kalantar-Zadeh, Kourosh
aded6a64-8612-40b7-aae9-233fbae916a6
June 2021
Xie, Wanjie
718129dc-cebc-4007-a495-a791960284d4
Allioux, Francois Marie
06fa4c1f-9d93-4fa4-bff6-2b4b4d497e95
Ou, Jian Zhen
80dec509-7411-417a-b56f-9d693b3510ca
Miyako, Eijiro
4b3c797a-d2b6-46a4-9f21-3bba058c82fe
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Kalantar-Zadeh, Kourosh
aded6a64-8612-40b7-aae9-233fbae916a6
Xie, Wanjie, Allioux, Francois Marie, Ou, Jian Zhen, Miyako, Eijiro, Tang, Shi Yang and Kalantar-Zadeh, Kourosh
(2021)
Gallium-based liquid metal particles for therapeutics.
Trends in Biotechnology, 39 (6), .
(doi:10.1016/j.tibtech.2020.10.005).
Abstract
Gallium (Ga) and Ga-based liquid metal (LM) alloys offer low toxicity, excellent electrical and thermal conductivities, and fluidity at or near room temperature. Ga-based LM particles (LMPs) synthesized from these LMs exhibit both fluidic and metallic properties and are suitable for versatile functionalization in therapeutics. Functionalized Ga-based LMPs can be actuated using physical or chemical stimuli for drug delivery, cancer treatment, bioimaging, and biosensing. However, many of the fundamentals of their unique characteristics for therapeutics remain underexplored. We present the most recent advances in Ga-based LMPs in therapeutics based on the underlying mechanisms of their design and implementation. We also highlight some future biotechnological opportunities for Ga-based LMPs based on their extraordinary advantages.
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Published date: June 2021
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Funding Information:
This work has been accomplished with the support of an Australian Research Council (ARC) Laureate Fellowship grant ( FL180100053 ).
Publisher Copyright:
© 2020 Elsevier Ltd
Keywords:
gallium, liquid metal particles, therapeutics
Identifiers
Local EPrints ID: 481762
URI: http://eprints.soton.ac.uk/id/eprint/481762
ISSN: 0167-7799
PURE UUID: 00726e46-b04b-474e-a22b-a25fa5135b6a
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Date deposited: 07 Sep 2023 16:35
Last modified: 18 Mar 2024 04:13
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Contributors
Author:
Wanjie Xie
Author:
Francois Marie Allioux
Author:
Jian Zhen Ou
Author:
Eijiro Miyako
Author:
Shi Yang Tang
Author:
Kourosh Kalantar-Zadeh
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