DNA methylation at the suppressor of cytokine signaling 3 (SOCS3) gene influences height in childhood

Accepted/In Press date: 1 August 2023

e-pub ahead of print date: 25 August 2023

Published date: 25 August 2023

Additional Information: Funding Information: MMNP: We are grateful to the families who took part, and the team of fieldworkers, nurses, research assistants, and data managers who carried out the study. The original trial was supported by the Wellcome Trust, United Kingdom; the Medical Research Council, United Kingdom; the Department for International Development, United Kingdom; USAID; the Parthenon Trust, Switzerland; and the Industrial Credit and Investment Corporation of India Bank Ltd Social Initiatives Group, Mumbai, India. The SARAS KIDS children’s follow-up study was funded by the Medical Research Council, UK research grant no: MR/M005186/1. PMMST and ENID: We thank all the study participants in West Kiang, The Gambia for their time and commitment. We also thank members of the laboratory and field teams. We acknowledge the work of Z. Herceg, M.N. Routledge, Y.Y. Gong, and H. Hernandez-Vargas in acquiring the ENID 2-year 450k array data and Toby Candler in acquiring samples and data in the follow-up study in 5–7-year-old children. PMMST was supported by MRC (U1232661351, U105960371, and MC-A760-5QX00) and DFID under the MRC/DFID Concordat, and other members of the Gambian team were supported by MRC grants U105960371, U123261351 and MR/M01424X/1. The ENID trial was jointly funded by the UK Medical Research Council (MRC) and the Department for International Development (DFID) under the MRC/DFID Concordat agreement (MRC Program MC-A760-5QX00). Methylation analysis of ENID early childhood samples was supported by the Bill & Melinda Gates Foundation (grant no. OPP1 066947). The generation of methylation data from the same cohort in late childhood was funded by the UK MRC (grant no. MC_PC_MR/RO20183/1). The EMPHASIS study was jointly funded by MRC, DFID, and the Department of Biotechnology (DBT), Ministry of Science and Technology, India, under the Newton Fund initiative (MRC Grant No.: MR/ N006208/1 and DBT Grant No.: BT/IN/DBT-MRC/DFID/24/GRC/2015–16). MPC: We thank all the participating families, CSI Holdsworth Memorial Hospital staff, the research team, and the staff of the MRC Lifecourse Epidemiology Unit for their support. MPC was supported by the Parthenon Trust, Switzerland; the Wellcome Trust, UK; the MRC, UK and the Department for International Development (UK). The follow-up at 21 years was supported by the DBT/Wellcome Trust India Alliance Fellowship [Grant Number: IA/CPHS/16/1/502655]. Thanks to the Council of Scientific and Industrial Research (CSIR), Ministry of Science and Technology, Government of India, India for funds for generating high-throughput genomic and methylation data. ALSPAC: We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. Hannah R. Elliott, Eleanor C.M. Sanderson, and Caroline L. Relton are members of the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council and the University of Bristol (MC_UU_00011/5 and MC_UU_00011/1). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ). GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. Funding Information: MMNP: We are grateful to the families who took part, and the team of fieldworkers, nurses, research assistants, and data managers who carried out the study. The original trial was supported by the Wellcome Trust, United Kingdom; the Medical Research Council, United Kingdom; the Department for International Development, United Kingdom; USAID; the Parthenon Trust, Switzerland; and the Industrial Credit and Investment Corporation of India Bank Ltd Social Initiatives Group, Mumbai, India. The SARAS KIDS children’s follow-up study was funded by the Medical Research Council, UK research grant no: MR/M005186/1. PMMST and ENID: We thank all the study participants in West Kiang, The Gambia for their time and commitment. We also thank members of the laboratory and field teams. We acknowledge the work of Z. Herceg, M.N. Routledge, Y.Y. Gong, and H. Hernandez-Vargas in acquiring the ENID 2-year 450k array data and Toby Candler in acquiring samples and data in the follow-up study in 5–7-year-old children. PMMST was supported by MRC (U1232661351, U105960371, and MC-A760-5QX00) and DFID under the MRC/DFID Concordat, and other members of the Gambian team were supported by MRC grants U105960371, U123261351 and MR/M01424X/1. The ENID trial was jointly funded by the UK Medical Research Council (MRC) and the Department for International Development (DFID) under the MRC/DFID Concordat agreement (MRC Program MC-A760-5QX00). Methylation analysis of ENID early childhood samples was supported by the Bill & Melinda Gates Foundation (grant no. OPP1 066947). The generation of methylation data from the same cohort in late childhood was funded by the UK MRC (grant no. MC_PC_MR/RO20183/1). The EMPHASIS study was jointly funded by MRC, DFID, and the Department of Biotechnology (DBT), Ministry of Science and Technology, India, under the Newton Fund initiative (MRC Grant No.: MR/ N006208/1 and DBT Grant No.: BT/IN/DBT-MRC/DFID/24/GRC/2015–16). MPC: We thank all the participating families, CSI Holdsworth Memorial Hospital staff, the research team, and the staff of the MRC Lifecourse Epidemiology Unit for their support. MPC was supported by the Parthenon Trust, Switzerland; the Wellcome Trust, UK; the MRC, UK and the Department for International Development (UK). The follow-up at 21 years was supported by the DBT/Wellcome Trust India Alliance Fellowship [Grant Number: IA/CPHS/16/1/502655]. Thanks to the Council of Scientific and Industrial Research (CSIR), Ministry of Science and Technology, Government of India, India for funds for generating high-throughput genomic and methylation data. ALSPAC: We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists, and nurses. Hannah R. Elliott, Eleanor C.M. Sanderson, and Caroline L. Relton are members of the Medical Research Council Integrative Epidemiology Unit at the University of Bristol, which is supported by the Medical Research Council and the University of Bristol (MC_UU_00011/5 and MC_UU_00011/1). The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf). GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. Publisher Copyright: © 2023, Springer Nature Limited.

Keywords: Child, Cytokines, DNA Methylation/genetics, Epigenesis, Genetic, Epigenomics, Female, Humans, Pregnancy, Suppressor of Cytokine Signaling 3 Protein/genetics, Suppressor of Cytokine Signaling Proteins/genetics

Local EPrints ID: 481787

URI: http://eprints.soton.ac.uk/id/eprint/481787

DOI: doi:10.1038/s41467-023-40607-0

ISSN: 2041-1723

PURE UUID: 304794cc-7457-44f4-8a28-671e97a21086

ORCID for Kate A. Ward: orcid.org/0000-0001-7034-6750

ORCID for Karen A. Lillycrop: orcid.org/0000-0001-7350-5489

ORCID for Caroline H.D. Fall: orcid.org/0000-0003-4402-5552

Date deposited: 07 Sep 2023 16:42

Last modified: 06 Jun 2024 01:55