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Metabolic-associated fatty liver disease is associated with colorectal adenomas in young and older Korean adults

Metabolic-associated fatty liver disease is associated with colorectal adenomas in young and older Korean adults
Metabolic-associated fatty liver disease is associated with colorectal adenomas in young and older Korean adults
Background and aims: given that the majority of colorectal cancers (CRCs) develop from high-risk adenomas, identifying risk factors for high-risk adenomas is important. The relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and the risk of colorectal adenoma in young adults remains unclear. We aimed to evaluate this relationship in adults <50 (younger) and ≥50 (older) years of age.

Methods: this cross-sectional study included 184 792 Korean adults (80% <50 years of age) who all underwent liver ultrasound and colonoscopy. Participants were grouped into those with and without MAFLD and classified by adenoma presence into no adenoma, low-risk adenoma, or high-risk adenoma (defined as ≥3 adenomas, any ≥10 mm, or adenoma with high-grade dysplasia/villous features).

Results: the prevalence of low- and high-risk adenomas among young and older adults was 9.6% and 0.8% and 22.3% and 4.8%, respectively. MAFLD was associated with an increased prevalence of low- and high-risk adenomas in young and older adults. Young adults with MAFLD had a 1.30 (95% CIs 1.26–1.35) and 1.40 (1.23–1.59) times higher prevalence of low- and high-risk adenomas, respectively, compared to those without MAFLD. These associations were consistent even in lean adults (BMI < 23 kg/m2) and those without a family history of CRC.

Conclusions: MAFLD is associated with an increased prevalence of low- and high-risk adenomas in Korean adults, regardless of age or obesity status. Whether reducing metabolic risk factors, such as MAFLD, reduces the risk of precancerous lesions and ultimately reduces the risk of early-onset CRC requires further investigation.
metabolic dysfunction-associated fatty liver disease, obesity, young-onset colorectal adenoma
1478-3223
2548-2559
Chang, Jiwon
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Chang, Yoosoo
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Cho, Yoosun
6748a316-767a-46b6-a432-1bc7cf1b2738
Jung, Hyun-Suk
5bd887be-d79e-4b38-86cc-4dca6b78209c
Park, Dong-Il
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Park, Soo-Kyung
33817b5f-cef6-4520-bf4c-555bb70ef8c4
Ham, Soo-Youn
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Wild, Sarah H.
c7bee4a7-3c85-4640-b523-3d79e589b6d2
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Ryu, Seungho
6c420b42-a867-4dc2-9673-937a4733dae8
Chang, Jiwon
7c6eaf97-516a-4115-ba8b-64f8cfdcd38f
Chang, Yoosoo
f410d7b0-86d6-40ae-8474-bf85bb6b1d1b
Cho, Yoosun
6748a316-767a-46b6-a432-1bc7cf1b2738
Jung, Hyun-Suk
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Park, Dong-Il
890616e4-4aef-4cef-9946-6b4296008c4f
Park, Soo-Kyung
33817b5f-cef6-4520-bf4c-555bb70ef8c4
Ham, Soo-Youn
025e5280-9818-4f3b-b4ff-668dda039410
Wild, Sarah H.
c7bee4a7-3c85-4640-b523-3d79e589b6d2
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Ryu, Seungho
6c420b42-a867-4dc2-9673-937a4733dae8

Chang, Jiwon, Chang, Yoosoo, Cho, Yoosun, Jung, Hyun-Suk, Park, Dong-Il, Park, Soo-Kyung, Ham, Soo-Youn, Wild, Sarah H., Byrne, Christopher and Ryu, Seungho (2023) Metabolic-associated fatty liver disease is associated with colorectal adenomas in young and older Korean adults. Liver International, 43 (11), 2548-2559. (doi:10.1111/liv.15738).

Record type: Article

Abstract

Background and aims: given that the majority of colorectal cancers (CRCs) develop from high-risk adenomas, identifying risk factors for high-risk adenomas is important. The relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and the risk of colorectal adenoma in young adults remains unclear. We aimed to evaluate this relationship in adults <50 (younger) and ≥50 (older) years of age.

Methods: this cross-sectional study included 184 792 Korean adults (80% <50 years of age) who all underwent liver ultrasound and colonoscopy. Participants were grouped into those with and without MAFLD and classified by adenoma presence into no adenoma, low-risk adenoma, or high-risk adenoma (defined as ≥3 adenomas, any ≥10 mm, or adenoma with high-grade dysplasia/villous features).

Results: the prevalence of low- and high-risk adenomas among young and older adults was 9.6% and 0.8% and 22.3% and 4.8%, respectively. MAFLD was associated with an increased prevalence of low- and high-risk adenomas in young and older adults. Young adults with MAFLD had a 1.30 (95% CIs 1.26–1.35) and 1.40 (1.23–1.59) times higher prevalence of low- and high-risk adenomas, respectively, compared to those without MAFLD. These associations were consistent even in lean adults (BMI < 23 kg/m2) and those without a family history of CRC.

Conclusions: MAFLD is associated with an increased prevalence of low- and high-risk adenomas in Korean adults, regardless of age or obesity status. Whether reducing metabolic risk factors, such as MAFLD, reduces the risk of precancerous lesions and ultimately reduces the risk of early-onset CRC requires further investigation.

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Accepted/In Press date: 5 September 2023
e-pub ahead of print date: 22 September 2023
Published date: November 2023
Additional Information: Funding Information: This study was supported by the SKKU Excellence in Research Award Research Fund, Sungkyunkwan University (2021), and by the National Research Foundation of Korea, funded by the Ministry of Science, ICT, and Future Planning (NRF‐2021R1A2C1012626). CDB is supported in part by the Southampton National Institute for Health and Care Research Biomedical Research Centre NIHR , NIHR203319. grant code Funding Information: We extend our sincere gratitude to the dedicated staff members of the Kangbuk Samsung Health Study for their unwavering commitment, diligent efforts, and invaluable support. Publisher Copyright: © 2023 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Keywords: metabolic dysfunction-associated fatty liver disease, obesity, young-onset colorectal adenoma

Identifiers

Local EPrints ID: 481870
URI: http://eprints.soton.ac.uk/id/eprint/481870
ISSN: 1478-3223
PURE UUID: b310148f-774e-4586-8a39-1b7de92ad5ae
ORCID for Christopher Byrne: ORCID iD orcid.org/0000-0001-6322-7753

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Date deposited: 12 Sep 2023 16:33
Last modified: 22 Sep 2024 04:01

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Contributors

Author: Jiwon Chang
Author: Yoosoo Chang
Author: Yoosun Cho
Author: Hyun-Suk Jung
Author: Dong-Il Park
Author: Soo-Kyung Park
Author: Soo-Youn Ham
Author: Sarah H. Wild
Author: Seungho Ryu

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