Recent advances in non-optical microfluidic platforms for bioparticle detection
Recent advances in non-optical microfluidic platforms for bioparticle detection
The effective analysis of the basic structure and functional information of bioparticles are of great significance for the early diagnosis of diseases. The synergism between microfluidics and particle manipulation/detection technologies offers enhanced system integration capability and test accuracy for the detection of various bioparticles. Most microfluidic detection platforms are based on optical strategies such as fluorescence, absorbance, and image recognition. Although optical microfluidic platforms have proven their capabilities in the practical clinical detection of bioparticles, shortcomings such as expensive components and whole bulky devices have limited their practicality in the development of point-of-care testing (POCT) systems to be used in remote and underdeveloped areas. Therefore, there is an urgent need to develop cost-effective non-optical microfluidic platforms for bioparticle detection that can act as alternatives to optical counterparts. In this review, we first briefly summarise passive and active methods for bioparticle manipulation in microfluidics. Then, we survey the latest progress in non-optical microfluidic strategies based on electrical, magnetic, and acoustic techniques for bioparticle detection. Finally, a perspective is offered, clarifying challenges faced by current non-optical platforms in developing practical POCT devices and clinical applications.
Bioparticle detection, Microfluidics, Non-optical methods, Point-of-care testing, Microfluidic Analytical Techniques, Point-of-Care Systems, Point-of-Care Testing, Microfluidics/methods, Biosensing Techniques, Lab-On-A-Chip Devices
114944
Bayinqiaoge,
fb90e81b-7a46-4383-8e5f-373ae47c69bd
Zhang, Yuxin
f858a4e3-2841-46cb-a6d7-a5230e25f467
Cole, Tim
78cebdf5-e360-4e8e-9dea-ba4b88306980
Zheng, Jiahao
44791733-cef3-4cca-9e18-1779b64e3b84
Guo, Jinhong
d65d7044-32c8-4028-a6b3-d221ad8bf006
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
15 February 2023
Bayinqiaoge,
fb90e81b-7a46-4383-8e5f-373ae47c69bd
Zhang, Yuxin
f858a4e3-2841-46cb-a6d7-a5230e25f467
Cole, Tim
78cebdf5-e360-4e8e-9dea-ba4b88306980
Zheng, Jiahao
44791733-cef3-4cca-9e18-1779b64e3b84
Guo, Jinhong
d65d7044-32c8-4028-a6b3-d221ad8bf006
Tang, Shi Yang
1d0f15c6-2a3e-4bad-a3d8-fc267db93ed4
Bayinqiaoge, , Zhang, Yuxin, Cole, Tim, Zheng, Jiahao, Guo, Jinhong and Tang, Shi Yang
(2023)
Recent advances in non-optical microfluidic platforms for bioparticle detection.
Biosensors and Bioelectronics, 222, , [114944].
(doi:10.1016/j.bios.2022.114944).
Abstract
The effective analysis of the basic structure and functional information of bioparticles are of great significance for the early diagnosis of diseases. The synergism between microfluidics and particle manipulation/detection technologies offers enhanced system integration capability and test accuracy for the detection of various bioparticles. Most microfluidic detection platforms are based on optical strategies such as fluorescence, absorbance, and image recognition. Although optical microfluidic platforms have proven their capabilities in the practical clinical detection of bioparticles, shortcomings such as expensive components and whole bulky devices have limited their practicality in the development of point-of-care testing (POCT) systems to be used in remote and underdeveloped areas. Therefore, there is an urgent need to develop cost-effective non-optical microfluidic platforms for bioparticle detection that can act as alternatives to optical counterparts. In this review, we first briefly summarise passive and active methods for bioparticle manipulation in microfluidics. Then, we survey the latest progress in non-optical microfluidic strategies based on electrical, magnetic, and acoustic techniques for bioparticle detection. Finally, a perspective is offered, clarifying challenges faced by current non-optical platforms in developing practical POCT devices and clinical applications.
Text
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Accepted/In Press date: 22 November 2022
Published date: 15 February 2023
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Funding Information:
This research received no external funding.
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© 2022 The Authors
Keywords:
Bioparticle detection, Microfluidics, Non-optical methods, Point-of-care testing, Microfluidic Analytical Techniques, Point-of-Care Systems, Point-of-Care Testing, Microfluidics/methods, Biosensing Techniques, Lab-On-A-Chip Devices
Identifiers
Local EPrints ID: 481991
URI: http://eprints.soton.ac.uk/id/eprint/481991
ISSN: 0956-5663
PURE UUID: aa36751d-670c-4d96-b950-530db777b216
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Date deposited: 14 Sep 2023 16:53
Last modified: 18 Mar 2024 04:13
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Contributors
Author:
Bayinqiaoge
Author:
Yuxin Zhang
Author:
Tim Cole
Author:
Jiahao Zheng
Author:
Jinhong Guo
Author:
Shi Yang Tang
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