Fasnall induces atypically transient stress granules independently of FASN inhibition
Fasnall induces atypically transient stress granules independently of FASN inhibition
Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of atypical Stress Granules, independently of fatty acid synthase inhibition, characterized by high internal mobility and rapid turnover.
Amen, Triana
388dc540-e819-4d07-8f1e-ee0f3949a54b
Kaganovich, Daniel
ebb13f4e-e925-4aef-88e7-ddc25ef52d8f
23 October 2020
Amen, Triana
388dc540-e819-4d07-8f1e-ee0f3949a54b
Kaganovich, Daniel
ebb13f4e-e925-4aef-88e7-ddc25ef52d8f
Amen, Triana and Kaganovich, Daniel
(2020)
Fasnall induces atypically transient stress granules independently of FASN inhibition.
iScience, 23 (10), [101550].
(doi:10.1016/j.isci.2020.101550).
Abstract
Stress Granule formation has been linked to the resistance of some cancer cells to chemotherapeutic intervention. A number of studies have proposed that certain anti-tumor compounds promote cancer cell survival by inducing Stress Granule formation, leading to increased cellular fitness and apoptosis avoidance. Here we show that a potent fatty acid synthase inhibitor, fasnall, known for its anti-tumor capabilities, triggers the formation of atypical Stress Granules, independently of fatty acid synthase inhibition, characterized by high internal mobility and rapid turnover.
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e-pub ahead of print date: 9 September 2020
Published date: 23 October 2020
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© 2020 The Author(s).
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Local EPrints ID: 482130
URI: http://eprints.soton.ac.uk/id/eprint/482130
ISSN: 2589-0042
PURE UUID: 95db4f8a-80ad-40ae-9cd4-19d3cb9b517c
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Date deposited: 19 Sep 2023 17:12
Last modified: 17 Mar 2024 04:22
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Author:
Triana Amen
Author:
Daniel Kaganovich
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