Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD

Asherson, Phillip, Brookes, Keeley, Franke, Barbara, Chen, Wai, Gill, Michael, Ebstein, Richard P., Buitelaar, Jan, Banaschewski, Tobias, Sonuga-Barke, Edmund, Eisenberg, Jacques, Manor, Iris, Miranda, Ana, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans-Christoph and Faraone, Stephen V. (2007) Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD. American Journal of Psychiatry, 164, 674-677. (doi:10.1176/appi.ajp.164.4.674).

Abstract

Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.

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