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Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD

Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD
Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.

1535-7228
674-677
Asherson, Phillip
382cc31a-eead-4caf-a085-59ece24d59d6
Brookes, Keeley
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Franke, Barbara
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Chen, Wai
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Gill, Michael
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Ebstein, Richard P.
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Buitelaar, Jan
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Banaschewski, Tobias
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Sonuga-Barke, Edmund
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Eisenberg, Jacques
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Manor, Iris
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Miranda, Ana
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Oades, Robert D.
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Roeyers, Herbert
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Rothenberger, Aribert
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Sergeant, Joseph
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Steinhausen, Hans-Christoph
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Faraone, Stephen V.
bd307516-e8db-4d38-b649-9d7d7caafe93
Asherson, Phillip
382cc31a-eead-4caf-a085-59ece24d59d6
Brookes, Keeley
dc587ce2-1d39-443c-b453-1d61629e929f
Franke, Barbara
f71c8989-a108-40c4-a159-80a1e60b56bf
Chen, Wai
ad64ca20-e814-4c31-a0ce-230287a988d4
Gill, Michael
408d1dfa-5205-4e50-8130-7b26aa8288e8
Ebstein, Richard P.
b7b70774-d400-4f33-84bf-11a21bc83170
Buitelaar, Jan
0a7a93a0-884f-4fe1-9cd8-6c9f9c5df4da
Banaschewski, Tobias
4627c589-04cc-4f5b-ac2d-05f547f63dfd
Sonuga-Barke, Edmund
bc80bf95-6cf9-4c76-a09d-eaaf0b717635
Eisenberg, Jacques
d0570918-b5a8-4ff2-b46b-9cd25cc2ef30
Manor, Iris
786b2370-0f31-4448-a3b3-484204b3b7e2
Miranda, Ana
e416878c-5ff3-4892-bb8f-17e8de0884ac
Oades, Robert D.
85d7ca21-1a76-458d-a3e3-69d4b13232db
Roeyers, Herbert
3554b6b3-e364-4a6a-9e8b-64f5188a6d60
Rothenberger, Aribert
736981ca-a16d-44b3-8312-2067dc792a6d
Sergeant, Joseph
9d13c879-0b3b-45df-8ba7-3978ca029ac5
Steinhausen, Hans-Christoph
991ad7f9-c5d1-4c61-8118-3d4895d2706d
Faraone, Stephen V.
bd307516-e8db-4d38-b649-9d7d7caafe93

Asherson, Phillip, Brookes, Keeley, Franke, Barbara, Chen, Wai, Gill, Michael, Ebstein, Richard P., Buitelaar, Jan, Banaschewski, Tobias, Sonuga-Barke, Edmund, Eisenberg, Jacques, Manor, Iris, Miranda, Ana, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph, Steinhausen, Hans-Christoph and Faraone, Stephen V. (2007) Confirmation that a specific haplotype of the dopamine transporter gene is associated with combined-type ADHD. American Journal of Psychiatry, 164, 674-677. (doi:10.1176/appi.ajp.164.4.674).

Record type: Article

Abstract

Objective: The primary purpose of this study was to confirm the association of a specific haplotype of the dopamine transporter gene and attention deficit hyperactivity disorder (ADHD), which could be one source of the heterogeneity seen across published studies. Method: The authors previously reported the association of ADHD with a subgroup of chromosomes containing specific alleles of two variable-number tandem repeat polymorphisms within the 3' untranslated region and intron 8 of the dopamine transporter gene. They now report on this association in a sample of ADHD combined-type probands. Results: The original observations were confirmed, with an overall odds ratio of 1.4 across samples. Conclusions: These data challenge results of meta-analyses suggesting that dopamine transporter variation does not have an effect on the risk for ADHD, and they indicate that further investigation of functional variation in the gene is required.

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Published date: April 2007

Identifiers

Local EPrints ID: 48220
URI: https://eprints.soton.ac.uk/id/eprint/48220
ISSN: 1535-7228
PURE UUID: 9fb22e43-1a54-4672-868f-b3589c63936d

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Date deposited: 06 Sep 2007
Last modified: 13 Mar 2019 20:57

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Contributors

Author: Phillip Asherson
Author: Keeley Brookes
Author: Barbara Franke
Author: Wai Chen
Author: Michael Gill
Author: Richard P. Ebstein
Author: Jan Buitelaar
Author: Tobias Banaschewski
Author: Edmund Sonuga-Barke
Author: Jacques Eisenberg
Author: Iris Manor
Author: Ana Miranda
Author: Robert D. Oades
Author: Herbert Roeyers
Author: Aribert Rothenberger
Author: Joseph Sergeant
Author: Hans-Christoph Steinhausen
Author: Stephen V. Faraone

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