The University of Southampton
University of Southampton Institutional Repository

Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task

Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task
Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task
Rationale: Previous research investigating the effects of stimulants, such as methylphenidate (MPH), on children with attention deficit/hyperactivity disorder (AD/HD) has rarely included autonomic measures of arousal.
Objective: Our aim was to clarify the effects of MPH on central and autonomic measures in AD/HD children during a continuous performance task (CPT) using a naturalistic open-label study.
Method: Thirty-six boys (18 AD/HD and 18 control) participated in a CPT over two trial periods, allowing a more valid estimate of the effects of medication, rather than assuming that retesting per se has no substantial impact. MPH was administered to the AD/HD group 1 h prior to the second trial. Errors and reaction time (RT) were recorded as measures of performance, electrodermal activity as an autonomic nervous system measure and event-related potentials (ERPs) as an index of central nervous system activity.
Results: AD/HD children made more errors than controls in the first session, but no group differences were found after medication. No significant differences were observed for RT. Skin conductance level was found to be lower in AD/HD children than controls, but this difference was also ameliorated after medication. Conversely, mean skin conductance response to target stimuli was found not to differ between groups during the initial test phase but became significantly different in phase 2. ERP data showed topographic differences between groups in N1, P2, N2 and P3 at the initial test phase, which were reduced at the second test.
Conclusion: Stimulant medication ameliorated some of the dysfunctions in AD/HD children, which are reflected in behavioural and ERP measures. These results, in combination with general differences in electrodermal activity, support a hypoarousal model of AD/HD, which can explain the action of MPH in these children.
ad/hd, stimulants, event-related potentials, skin conductance, cpt, boys, children, hypoarousal
0033-3158
81-91
Lawrence, C.A.
8420a683-7e75-48f7-bea6-81043a7bc856
Barry, R.J.
d0a7f116-c2a2-4ceb-87a0-bb7bcfebacf6
Clarke, A.R.
744624a2-10dc-4ae7-98cb-a2aef22d113f
Johnstone, S.J.
9d39f70e-22a7-487c-a877-049bc286ca95
McCarthy, R.
c8936841-8eeb-40da-8bfb-bacae664b2d4
Selikowitz, M
647cb4af-58da-4028-97cb-9143863c9d5d
Broyd, S.J.
e15c6cdb-c771-452e-b0d4-22de82b6ba8d
Lawrence, C.A.
8420a683-7e75-48f7-bea6-81043a7bc856
Barry, R.J.
d0a7f116-c2a2-4ceb-87a0-bb7bcfebacf6
Clarke, A.R.
744624a2-10dc-4ae7-98cb-a2aef22d113f
Johnstone, S.J.
9d39f70e-22a7-487c-a877-049bc286ca95
McCarthy, R.
c8936841-8eeb-40da-8bfb-bacae664b2d4
Selikowitz, M
647cb4af-58da-4028-97cb-9143863c9d5d
Broyd, S.J.
e15c6cdb-c771-452e-b0d4-22de82b6ba8d

Lawrence, C.A., Barry, R.J., Clarke, A.R., Johnstone, S.J., McCarthy, R., Selikowitz, M and Broyd, S.J. (2005) Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task. Psychopharmacology, 183 (1), 81-91. (doi:10.1007/s00213-005-0144-y).

Record type: Article

Abstract

Rationale: Previous research investigating the effects of stimulants, such as methylphenidate (MPH), on children with attention deficit/hyperactivity disorder (AD/HD) has rarely included autonomic measures of arousal.
Objective: Our aim was to clarify the effects of MPH on central and autonomic measures in AD/HD children during a continuous performance task (CPT) using a naturalistic open-label study.
Method: Thirty-six boys (18 AD/HD and 18 control) participated in a CPT over two trial periods, allowing a more valid estimate of the effects of medication, rather than assuming that retesting per se has no substantial impact. MPH was administered to the AD/HD group 1 h prior to the second trial. Errors and reaction time (RT) were recorded as measures of performance, electrodermal activity as an autonomic nervous system measure and event-related potentials (ERPs) as an index of central nervous system activity.
Results: AD/HD children made more errors than controls in the first session, but no group differences were found after medication. No significant differences were observed for RT. Skin conductance level was found to be lower in AD/HD children than controls, but this difference was also ameliorated after medication. Conversely, mean skin conductance response to target stimuli was found not to differ between groups during the initial test phase but became significantly different in phase 2. ERP data showed topographic differences between groups in N1, P2, N2 and P3 at the initial test phase, which were reduced at the second test.
Conclusion: Stimulant medication ameliorated some of the dysfunctions in AD/HD children, which are reflected in behavioural and ERP measures. These results, in combination with general differences in electrodermal activity, support a hypoarousal model of AD/HD, which can explain the action of MPH in these children.

Full text not available from this repository.

More information

Published date: 2005
Keywords: ad/hd, stimulants, event-related potentials, skin conductance, cpt, boys, children, hypoarousal

Identifiers

Local EPrints ID: 48224
URI: http://eprints.soton.ac.uk/id/eprint/48224
ISSN: 0033-3158
PURE UUID: 6c703716-c9b4-4deb-8cc0-a87258494ab6

Catalogue record

Date deposited: 06 Sep 2007
Last modified: 13 Mar 2019 20:57

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×