Activation of the hippocampal AC-cAMP-PKA-CREB-BDNF signaling pathway using WTKYR in depression model rats
Activation of the hippocampal AC-cAMP-PKA-CREB-BDNF signaling pathway using WTKYR in depression model rats
Depression, also called “depression disorder,” is characterized by a significant and persistent low mood. It has become a major refractory disease in the 21st century. In recent years, Chinese medicine has shown some important clinical value in the treatment of depression. Among them, the Warming and “Tonifying” Kidney-Yang Recipe (WTKYR) has been demonstrated to have obvious effects in the clinical treatments of depression; however, the mechanism remains unclear. This study is based on the adenylyl cyclase (AC)—cyclic adenosine monophosphate (cAMP)—protein kinase A (PKA)—cAMP response element-binding protein (CREB)—brain derived neurotrophic factor (BDNF) signaling pathway, aiming to investigate the mechanism of WTKYR. The results showed that WTKYR can upregulate AC-cAMP-PKA-CREB-BDNF in the hippocampus of depression model rats and alleviate its depressive symptoms, which may be the mechanism of WTKYR.
Chinese medicine, Depression disorder, Hippocampus, Signaling pathway, WTKYR
1245-1250
Peng, Yangzhi
c44ed04c-7be6-44d7-b3a6-82a0a2a5ea21
Zhang, Chengchen
abc47c06-4b99-4aed-be72-463f211e9dfa
Su, Yue
bb3264aa-5a18-443d-8e71-041404abf732
Wang, Zewen
f633e063-50a3-437e-9aac-816665fd9785
Jiang, Yong
99df90d6-6cfb-4c97-870a-39af5a434fb1
Peng, Yangzhi
c44ed04c-7be6-44d7-b3a6-82a0a2a5ea21
Zhang, Chengchen
abc47c06-4b99-4aed-be72-463f211e9dfa
Su, Yue
bb3264aa-5a18-443d-8e71-041404abf732
Wang, Zewen
f633e063-50a3-437e-9aac-816665fd9785
Jiang, Yong
99df90d6-6cfb-4c97-870a-39af5a434fb1
Peng, Yangzhi, Zhang, Chengchen, Su, Yue, Wang, Zewen and Jiang, Yong
(2018)
Activation of the hippocampal AC-cAMP-PKA-CREB-BDNF signaling pathway using WTKYR in depression model rats.
Electrophoresis, 40 (8), .
(doi:10.1002/elps.201800381).
Abstract
Depression, also called “depression disorder,” is characterized by a significant and persistent low mood. It has become a major refractory disease in the 21st century. In recent years, Chinese medicine has shown some important clinical value in the treatment of depression. Among them, the Warming and “Tonifying” Kidney-Yang Recipe (WTKYR) has been demonstrated to have obvious effects in the clinical treatments of depression; however, the mechanism remains unclear. This study is based on the adenylyl cyclase (AC)—cyclic adenosine monophosphate (cAMP)—protein kinase A (PKA)—cAMP response element-binding protein (CREB)—brain derived neurotrophic factor (BDNF) signaling pathway, aiming to investigate the mechanism of WTKYR. The results showed that WTKYR can upregulate AC-cAMP-PKA-CREB-BDNF in the hippocampus of depression model rats and alleviate its depressive symptoms, which may be the mechanism of WTKYR.
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e-pub ahead of print date: 4 December 2018
Additional Information:
Funding Information:
This research was supported by the National Natural Science Foundation of China (81302900).
Publisher Copyright:
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Keywords:
Chinese medicine, Depression disorder, Hippocampus, Signaling pathway, WTKYR
Identifiers
Local EPrints ID: 482318
URI: http://eprints.soton.ac.uk/id/eprint/482318
ISSN: 0173-0835
PURE UUID: ef76c8ef-9b4e-4abe-adad-f18913929814
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Date deposited: 26 Sep 2023 16:52
Last modified: 18 Mar 2024 04:15
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Contributors
Author:
Yangzhi Peng
Author:
Chengchen Zhang
Author:
Yue Su
Author:
Zewen Wang
Author:
Yong Jiang
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