European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia
European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia
From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. Our scientific and clinical knowledge underpinning these requirements continues to evolve, as do laboratory methods and technologies. The European LeukemiaNet convened an expert panel to critically consider the current status of genetic laboratory approaches to help diagnose and manage CML patients. Our recommendations focus on current best practice and highlight the strengths and pitfalls of commonly used laboratory tests.
2150-2167
Cross, Nicholas C.P.
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Ernst, Thomas
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Branford, Susan
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Cayuela, Jean-Michel
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Deininger, Michael
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Fabarius, Alice
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Hwan Kim, Dennis Dong
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Machova-Polakova, Katerina
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Radich, Jerald P.
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Hehlmann, Rudiger
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Hochhaus, Andreas
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Apperley, Jane F.
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Soverini, Simona
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1 November 2023
Cross, Nicholas C.P.
f87650da-b908-4a34-b31b-d62c5f186fe4
Ernst, Thomas
96c7805b-c900-4545-9f93-1a83d789cb56
Branford, Susan
fc8a5cf1-4c36-48b5-92f1-835ee701260f
Cayuela, Jean-Michel
006c25d4-e8b6-4e21-82a1-10702e055c72
Deininger, Michael
a2ce09a6-39d6-472f-879b-a6e611c2e585
Fabarius, Alice
5c31b1e0-c6da-49b8-843a-5b0ca736e5a2
Hwan Kim, Dennis Dong
6798ce3e-81ec-4ee6-8cec-3b2517ca0a68
Machova-Polakova, Katerina
4e060d78-afa5-47a4-808f-d1fdffe66518
Radich, Jerald P.
98047ffe-cdce-494e-bfc1-58fd4dfc24aa
Hehlmann, Rudiger
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Hochhaus, Andreas
b37b9b7d-85ff-455e-994d-fcc2adf94088
Apperley, Jane F.
949b93c6-950b-4dd2-b033-4b2b47c54576
Soverini, Simona
a43c135a-5658-4429-93dc-1855227574a1
Cross, Nicholas C.P., Ernst, Thomas, Branford, Susan, Cayuela, Jean-Michel, Deininger, Michael, Fabarius, Alice, Hwan Kim, Dennis Dong, Machova-Polakova, Katerina, Radich, Jerald P., Hehlmann, Rudiger, Hochhaus, Andreas, Apperley, Jane F. and Soverini, Simona
(2023)
European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Leukemia, 37 (11), .
(doi:10.1038/s41375-023-02048-y).
Abstract
From the laboratory perspective, effective management of patients with chronic myeloid leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential assessment of levels of residual disease and investigation of possible reasons for resistance, relapse or progression. Our scientific and clinical knowledge underpinning these requirements continues to evolve, as do laboratory methods and technologies. The European LeukemiaNet convened an expert panel to critically consider the current status of genetic laboratory approaches to help diagnose and manage CML patients. Our recommendations focus on current best practice and highlight the strengths and pitfalls of commonly used laboratory tests.
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s41375-023-02048-y
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Accepted/In Press date: 20 September 2023
e-pub ahead of print date: 4 October 2023
Published date: 1 November 2023
Additional Information:
Funding Information:
NCPC, TE, KMP, AH and SS were supported by the ‘European Treatment and Outcome Study for CML’, EUTOS. We thank Jorge Cortes (Augusta, GA, USA), Valentín García-Gutiérrez (Madrid, Spain), Oliver Hantschel (Marburg, Germany), Qian Jiang (Beijing, China), Dong Wook Kim (Seoul, South Korea), Hugues de Lavallade (London, UK), Hemant Malhotra (Jaipur, India), Katia Pagnano (Campinas, Brazil), Carolina Pavlovsky (Buenos Aires, Argentina), Delphine Rea (Paris, France), Debbie Travis (Sheffield, UK), Peter Westerweel (Dordrecht, The Netherlands) and Helen White (Salisbury, UK) for helpful comments and suggestions.
Funding Information:
NCPC, TE, KMP, AH and SS were supported by the ‘European Treatment and Outcome Study for CML’, EUTOS. We thank Jorge Cortes (Augusta, GA, USA), Valentín García-Gutiérrez (Madrid, Spain), Oliver Hantschel (Marburg, Germany), Qian Jiang (Beijing, China), Dong Wook Kim (Seoul, South Korea), Hugues de Lavallade (London, UK), Hemant Malhotra (Jaipur, India), Katia Pagnano (Campinas, Brazil), Carolina Pavlovsky (Buenos Aires, Argentina), Delphine Rea (Paris, France), Debbie Travis (Sheffield, UK), Peter Westerweel (Dordrecht, The Netherlands) and Helen White (Salisbury, UK) for helpful comments and suggestions.
Publisher Copyright:
© 2023, The Author(s).
Identifiers
Local EPrints ID: 482832
URI: http://eprints.soton.ac.uk/id/eprint/482832
ISSN: 0887-6924
PURE UUID: 02841020-a173-47b5-8859-1654aab2ee5b
Catalogue record
Date deposited: 13 Oct 2023 16:32
Last modified: 18 Mar 2024 02:54
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Contributors
Author:
Thomas Ernst
Author:
Susan Branford
Author:
Jean-Michel Cayuela
Author:
Michael Deininger
Author:
Alice Fabarius
Author:
Dennis Dong Hwan Kim
Author:
Katerina Machova-Polakova
Author:
Jerald P. Radich
Author:
Rudiger Hehlmann
Author:
Andreas Hochhaus
Author:
Jane F. Apperley
Author:
Simona Soverini
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