READ ME File For 'Dataset title' Hearing and Inflammation Data Dataset DOI: 10.5258/SOTON/D2823 Date that the file was created: 13th October 2023, ------------------- GENERAL INFORMATION ------------------- ReadMe Author: Tracey Newman , University of Southampton [0000 0002 3727 9258] Date of data collection: 2013-2019 Information about geographic location of data collection: Southampton, UK Related projects: 'The effect of Inflammation in the progression of age related hearing loss' [Doctoral thesis] Developing SERS-based point-of-care inflammatory monitoring for risk identification of worsening progression of age-related disease [Doctoral Thesis] -------------------------- SHARING/ACCESS INFORMATION -------------------------- Licenses/restrictions placed on the data, or limitations of reuse: Data can be requested by bone fide researchers, evidence of appropriate ethical approval will be needed for full access. Recommended citation for the data: This dataset supports the publication: AUTHORS: Rachel L Kidd, Akosua Agyemang-Prempeh, Alan Sanderson, Charlotte Stuart, Sumeet Mahajan, Carl A Verschuur, Tracey A Newman. TITLE:Longitudinal urinary neopterin predicts incidence and increased progression of age-related hearing loss JOURNAL: Nature Scientific Reports PAPER DOI IF KNOWN: -------------------- DATA & FILE OVERVIEW -------------------- Dataset is available 'on request' to bone fide researchers. This dataset contains: Hearing loss and Inflammation Data.xlsx This data was previously referred to as CH2 hearing loss and Inflammation data.xlsx Kidd, Rachel 'Developing SERS-based point-of-care inflammatory monitoring for risk identification of worsening progression of age-related disease' [Doctoral thesis].The only change made is the updating of the file name to enable sharing of the data for publication. -------------------------- METHODOLOGICAL INFORMATION -------------------------- Mass spec UNCR ACQUITY: UPC interfaced with a Waters Xevo triple quadrupole (TQD) mass spectrometer equipped with an electrospray ionization probe, column oven and autosampler. Reference doi:10.1373/jalm.2019.030007 (2019) Pure Tone Audiometry was performed in a sound proof booth using a GSI G1 Clinical Audiometer which was calibrated according to ISO-389-1:2000 Standards. PTA was performed according to the British Society of Audiology (BSA) recommended procedure. Air conduction thresholds were measured at 0.25, 0.5, 1, 2, 3, 4, 6 and 8 kHz for both ears. Thresholds for bone conduction were measured at 0.5, 1, 2, 3 and 4 kHz. Circulating inflammatory markers: A HemoCue WBC and differential analyser was used to give an automated White Blood Cell Count and differential count (neutrophils, lymphocytes, monocytes, eosinophils and basophils). Cytokine concentrations were measured using a MSD multi-spot Pro-inflammatory panel-1 kit. Methods for processing the data: Methods for processing data can be found in the paper Software- or Instrument-specific information needed to interpret the data, including software and hardware version numbers: Detail is reported int the paper Standards and calibration information, if appropriate: Reported or referred to in the paper Environmental/experimental conditions: Reported in the paper Describe any quality-assurance procedures performed on the data: Reported in the paper People involved with sample collection, processing, analysis and/or submission: Rachel Kidd, Akosua Agyemang-Prempeh, Alan Sanderson, Charlotte Stuart, Sumeet Mahajan, Carl A Verschuur, Tracey Newman, -------------------------- DATA-SPECIFIC INFORMATION -------------------------- Variable list, defining any abbreviations, units of measure, codes or symbols used: MAss Șpec UNCC = Mass Spectrometry Urine Neopterin Creatinine Ratio arbitrary units Baseline Hearing = pure tone audiometry measures Year 2 hearing = pure tone audiometry measures Year 3 hearing = pure tone audiometry measures Questionnaire = health data questionnaire Year 3 aud averages = Average values for the pure tone audiometry split by pure tone, low and high frequency averages Units dB [decibels] TEOAE = Transitory evoked otoacoustic emissions Number of variables: 18 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: ID - participant ID number Month 1 Month 2 Month 3 Month 4 Month 5 Month 6 Month 7 Month 8 Month 9 Month 10 Month 11 Month 12 Average - average value over the 12 months Standard deviation- SD of the average AUC/number of samples - area under curve divided by number of samples No. of samples - number of samples measured (out of 12) No. of times above 251- number of times the value months 1-12) was above 251 Baseline Hearing Number of variables:32 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: ID - Participant ID number 1R250 - Baseline right ear 250 Hz 1R500 Baseline right ear 500 Hz 1R1000 Baseline right ear 1000 Hz 1R2000 1R3000 1R4000 1R6000 1R8000 1R12000 1L250 Baseline left ear 250 Hz 1L500 Baseline left ear 500 Hz 1L1000 1L2000 1L3000 1L4000 1L6000 1L8000 1L12000 PTA_AV(250-8000) Baseline PTA average calculated 250-8000 Hz RPTA_AV(250-8000) Baseling right ear PTA Average LPTA_AV(250-8000) Baseline left ear PTA average LFA(250-1000) Baseline low frequency average calculated 250-1000Hz RLFA(250-1000) Baseline right low freq average LLFA(250-1000) Baseline left low freq average HFA(4000-8000) Baseline high frequency average (calculated 4000-8000Hz) RHFA(4000-8000) Baseline right high freq average LHFA(4000-8000) Baseline left high freq average WE_PTA_Av Baseline worse ear pure tone average WE_LFA Baseline worse ear low frequency average WE_HFA Baseline worse ear high frequency average Baseline degree of loss 0 = normal, 1= mild 2= moderate 3= severe Year 2 Hearing Number of variables:32 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: as above Year 3 Hearing Number of variables:32 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: as above Questionnaire Number of variables: 61 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: ID Participant ID number AGE at start age at start of study Age at 3rd test age at end of study GENDER gender 1=male 2=female OCCUPATION HEARINGQUIET difficulty hearing in quiet HEARINGNOISE difficulty hearing in noise NOISEXP history of noise exposure EXP DURATION duration of noise exposure TINNITUS tinnitus FHX family history of hearing loss PHX previous history of hearing problems HA hearing aid user SMOKING history of smoking GIVEUP given up before the age of 40 HYPERTENSION diagnosed with hypertension STATIN USE prescribed statins ANGINA/VALVULAR Dx diagnosis of angina or valvular disease STROKE history of stroke DM diagnosis of diabetes mellitus CVS Dx diagnosis of cardiovascular disease 1 or more Dx (CV or DM) 1 or more diagnoses of cardiovascular disease or diabetes 1_WBC(X109/L) Basline white blood cell count 1_NEU(X109/L) Baseline neutrophil count 1-LYMP(X109/L) Baseline lymphocyte count 1-MONO(X109/L) Baseline monocyte count 1-EOSIN(X109/L) Baseline eosinophil count 1-BASO(X109/L) Baseline basophil count 1-%NEU Baseline neutrophil % 1-%LYM Baseline lymphocyte % 1_%MON Baseline monocyte % 1_%EOS Baseline eosoniphil % 1_%BAS Baseine basophil % 2_WBC(X109/L) year 2 white blood cell count 2_NEU(X109/L) year 2 neutrophil count 2_LYMP(X109/L) 2_MONO(X109/L) 2_EOSIN(X109/L) 2_BASO(X109/L) 2_%NEU 2_%LYM 2_%MON 2_%EOS 2_%BAS Av_WBC average white blood cell count HEARINGQUIET study end difficulty hearing in quiet HEARINGNOISE study end difficulty hearing in noise NOISEXP EXP DURATION TINNITUS FHX PHX HA SMOKING GIVEUP HYPERTENSION STATIN USE ANGINA/VALVULAR Dx STROKE DM CVS Dx Year 3 AUD Averages Number of variables: 37 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: ID Participant ID number 3PTA_AV(250-8000) study end pure tone average 3RPTA_AV(250-8000) study end right ear pure tone average 3LPTA_AV(250-8000) study end left ear pure tone average 3LFA(250-1000) study end low frequency average 3RLFA(250-1000) study end right ear low freq average 3LLFA(250-1000) study end left ear low freq average 3HFA(4000-8000) study end high freq average 3RHFA(4000-8000) study end right ear high freq average 3LHFA(4000-8000) study end left ear high freq average 3WE_PTA_Av study end worse ear pure tone average 3WE_LFA study end worse ear low freq average 3WE_HFA study end worse ear high freq average PTA_AV(250-8000) Baseline pure tone average RPTA_AV(250-8000) Baseline right ear pure tone average LPTA_AV(250-8000) Baseline left ear pure tone average LFA(250-1000) Baseline low freq average RLFA(250-1000) Baseline right ear low freq average LLFA(250-1000) Baseline left ear low freq average HFA(4000-8000) Baseline high freq average RHFA(4000-8000) Baseline right ear high freq average LHFA(4000-8000) Baseline left ear high freq average WE_PTA_Av Baseline worst ear pure tone average WE_LFA Baseline worse ear low freq average WE_HFA Baseline worse ear high freq average DIFF_PTA_AV(250-8000) Difference between baseline and study end pure tone average DIFF_RPTA_AV(250-8000) Difference between baseline and study end right ear pure tone average DIFF_LPTA_AV(250-8000) Difference between baseline and study end left ear pure tone average DIFF_LFA(250-1000) Difference between baseline and study end low freq average DIFF_RLFA(250-1000) Difference between baseline and study end right ear low freq average DIFF_LLFA(250-1000) Difference between baseline and study end left ear low freq av DIFF_HFA(4000-8000) Difference between baseline and study end high freq av DIFF_RHFA(4000-8000) Difference between baseline and study end right ear high freq av DIFF_LHFA(4000-8000) Difference between baseline and study end left ear high freq av DIFF_WE_PTA_Av Difference between baseline and study end worst ear PTA Av DIFF_WE_LFA Difference between baseline and study end worse ear LFA DIFF_WE_HFA Difference between baseline and study end worse ear HFA TEOAE Number of variables:37 Number of cases/rows: 61 Variable list, defining any abbreviations, units of measure, codes or symbols used: ID Year 1 Reproducibility R- Year one Transient OAE right ear reproducibility Year 1 Reproducibility L- Year one Transient OAE left ear reproducibility 1_R_SNR1k Year 1 Transient OAE right ear 1000Hz 1_R_SNR1.5k Year 1 " " " 1500Hz 1_R_SNR2k Year 1 " " " 2000 Hz 1_R_SNR3k 1_R_SNR4k 1_L_SNR1k Year 1 Transient OAE left ear 1000 Hz 1_L_SN1.5k 1_L_SNR2k 1_L_SNR3k 1_L_SNR4k Year 1 Transient OAE left ear 4000 Hz Year 2 Reproducibility R- Year 2 Transient OAE right ear reproducibility Year 2 Reproducibility L- Year 2 Transient OAE left ear reproducibility 2_R_SNR1k Year 2 Transient OAE right ear 1000 Hz 2_R_SNR1.5k Year 2 Transient OAE right ear 1500Hz 2_R_SNR2k 2_R_SNR3k 2_R_SNR4k 2_L_SNR1k Year 2 Transient OAE left ear 1000Hz 2_L_SNR1.5k 2_L_SNR2k 2_L_SNR3k 2_L_SNR4k Year 2 Transient OAE left ear 4000Hz Year 3 Reproducibility R- Year 3 Transient OAE right ear reproducibility Year 3 Reproducibility L- Year 3 Transient OAE left ear reproducibility 3_R_SNR1k Year 3 Transient OAE right ear 1000 Hz 3_R_SNR1.5k 3_R_SNR2k 3_R_SNR3k 3_R_SNR4k 3_L_SNR1k Year 3 Transient OAE left ear 1000 Hz 3_L_SNR1.5k 3_L_SNR2k 3_L_SNR3k 3_L_SNR4k