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Maternal polyunsaturated fatty acids and allergic disease development in the offspring

Maternal polyunsaturated fatty acids and allergic disease development in the offspring
Maternal polyunsaturated fatty acids and allergic disease development in the offspring
To the Editor,
The increasing global prevalence of allergic diseases makes it imperative to identify modifiable risk factors for allergic disease development. Maternal antenatal plasma fatty acid composition has been proposed as a risk factor of infant allergic disease.1, 2 Polyunsaturated fatty acids (PUFAs) are key components of cell membranes and influence immune cell function by regulating membrane fluidity, intracellular signaling, and gene expression.3 They can be classified into n-3 and n-6 PUFAs, which are linked to production of anti-inflammatory and pro-inflammatory molecules, respectively.3 The fetoplacental unit lacks the desaturase enzymes required to synthesize long chain PUFAs so that, during pregnancy, the fetus is dependent on transplacental supply of PUFAs from the mother
allergic sensitization, eczema, polyunsaturated fatty acids, rhinitis, wheeze
0905-6157
Li, Ruyu
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Lau, Hui Xing
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Yap, Qai Ven
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Chan, Yiong Huak
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Tham, Elizabeth Huiwen
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Goh, Anne Eng Neo
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Van Bever, Hugo
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Eriksson, Johan Gunnar
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Chan, Shiao-Yng
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Tan, Kok Hian
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Chong, Yap Seng
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Lee, Bee Wah
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Shek, Lynette Pei-Chi
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Yap, Fabian Kok Peng
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Calder, Philip C
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Godfrey, Keith M
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Chong, Mary Foong-Fong
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Loo, Evelyn Xiu Ling
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et al.
Li, Ruyu
a7457a3c-c6b0-4eb4-87eb-e3720ebe7a59
Lau, Hui Xing
31f26ca2-82af-47d4-9077-84a4ebc19ba8
Yap, Qai Ven
ccb659a8-9154-46cd-8c86-57f3de54ff6e
Chan, Yiong Huak
3e6bb630-bddc-4713-8a9f-3d90c6dfe712
Tham, Elizabeth Huiwen
e22014ec-8242-478a-aafc-e4177164f814
Goh, Anne Eng Neo
9d869111-5368-420f-97dc-336f052bef41
Van Bever, Hugo
62a49213-7207-41ac-98aa-efe4b351dcb5
Eriksson, Johan Gunnar
eb96b1c5-af07-4a52-8a73-7541451d32cd
Chan, Shiao-Yng
3c9d8970-2cc4-430a-86a7-96f6029a5293
Tan, Kok Hian
4714c94d-334a-42ad-b879-f3aa3a931def
Chong, Yap Seng
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Lee, Bee Wah
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Shek, Lynette Pei-Chi
9a77403c-0e0c-4536-a5ad-628ce94b279a
Yap, Fabian Kok Peng
1e3770e8-40ec-4c13-ba8c-03dba436ead8
Calder, Philip C
1797e54f-378e-4dcb-80a4-3e30018f07a6
Godfrey, Keith M
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Chong, Mary Foong-Fong
1e188259-b1ab-4448-9e65-5b6a0fd99502
Loo, Evelyn Xiu Ling
229ed4b9-220f-4d95-a384-eb6529f6d2d6

Li, Ruyu, Lau, Hui Xing, Yap, Qai Ven, Calder, Philip C, Godfrey, Keith M and Loo, Evelyn Xiu Ling , et al. (2022) Maternal polyunsaturated fatty acids and allergic disease development in the offspring. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 33 (11), [e13876]. (doi:10.1111/pai.13876).

Record type: Letter

Abstract

To the Editor,
The increasing global prevalence of allergic diseases makes it imperative to identify modifiable risk factors for allergic disease development. Maternal antenatal plasma fatty acid composition has been proposed as a risk factor of infant allergic disease.1, 2 Polyunsaturated fatty acids (PUFAs) are key components of cell membranes and influence immune cell function by regulating membrane fluidity, intracellular signaling, and gene expression.3 They can be classified into n-3 and n-6 PUFAs, which are linked to production of anti-inflammatory and pro-inflammatory molecules, respectively.3 The fetoplacental unit lacks the desaturase enzymes required to synthesize long chain PUFAs so that, during pregnancy, the fetus is dependent on transplacental supply of PUFAs from the mother

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More information

Accepted/In Press date: 23 October 2022
Published date: 1 November 2022
Additional Information: Funding Information: This research is supported by the Singapore National Research Foundation under its Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health's National Medical Research Council (NMRC), Singapore—NMRC/TCR/004‐NUS/2008; NMRC/TCR/012‐NUHS/2014. Additional funding is provided by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. EH Tham is supported by the National Medical Research Council (NMRC) Transition Award grant (MOH‐TA18nov‐003) from NMRC, Singapore. KM Godfrey is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator [NF‐SI‐0515‐10042] and NIHR Southampton Biomedical Research Centre [IS‐BRC‐1215‐20004]), the European Union (Erasmus+ Programme ImpENSA 598488‐EPP‐1‐2018‐1‐DE‐EPPKA2‐CBHE‐JP) and the British Heart Foundation (RG/15/17/3174). Funding Information: We thank Marjorelee Colega Joren and Toh Jia Ying for their help with child fish oil supplementation data. We thank the GUSTO study group and all clinical and home-visit staff involved. The voluntary participation of all subjects is greatly appreciated. We thank Dr Anis Larbi and Dr Karen Tan Mei Ling for their help with cytokines analysis. The GUSTO study group includes Allan Sheppard, Amutha Chinnadurai, Anne Eng Neo Goh, Anne Rifkin-Graboi, Anqi Qiu, Arijit Biswas, Bee Wah Lee, Birit Froukje Philipp Broekman, Boon Long Quah, Chai Kiat Chng, Cheryl Shufen Ngo, Choon Looi Bong, Christiani Jeyakumar Henry, Daniel Yam Thiam Goh, Doris Ngiuk Lan Loh, Fabian Kok Peng Yap, George Seow Heong Yeo, Helen Yu Chen, Hugo P. S. van Bever, Iliana Magiati, Inez Bik Yun Wong, Ivy Yee-Man Lau, Jeevesh Kapur, Jenny L. Richmond, Jerry Kok Yen Chan, Joanna Dawn Holbrook, Joshua J. Gooley, Keith M. Godfrey, Kenneth Yung Chiang Kwek, Kok Hian Tan, Krishnamoorthy Naiduvaje, Leher Singh, Lin Lin Su, Lourdes Mary Daniel, Lynette Pei-Chi Shek, Marielle V. Fortier, Mark Hanson, Mary Foong-Fong Chong, Mary Rauff, Mei Chien Chua, Michael J. Meaney, Mya Thway Tint, Neerja Karnani, Ngee Lek, Oon Hoe Teoh, P. C. Wong, Peter David Gluckman, Pratibha Keshav Agarwal, Rob Martinus van Dam, Salome A. Rebello, Seang Mei Saw, Shang Chee Chong, Shirong Cai, Shu-E Soh, Sok Bee Lim, Stephen Chin-Ying Hsu, Victor Samuel Rajadurai, Walter Stunkel, Wee Meng Han, Wei Wei Pang, Yap Seng Chong, Yin Bun Cheung, Yiong Huak Chan, and Yung Seng Lee.
Keywords: allergic sensitization, eczema, polyunsaturated fatty acids, rhinitis, wheeze

Identifiers

Local EPrints ID: 482899
URI: http://eprints.soton.ac.uk/id/eprint/482899
ISSN: 0905-6157
PURE UUID: 03bdf29d-8435-4743-ad90-c464a470e148
ORCID for Philip C Calder: ORCID iD orcid.org/0000-0002-6038-710X
ORCID for Keith M Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 16 Oct 2023 16:58
Last modified: 17 Mar 2024 02:42

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Contributors

Author: Ruyu Li
Author: Hui Xing Lau
Author: Qai Ven Yap
Author: Yiong Huak Chan
Author: Elizabeth Huiwen Tham
Author: Anne Eng Neo Goh
Author: Hugo Van Bever
Author: Johan Gunnar Eriksson
Author: Shiao-Yng Chan
Author: Kok Hian Tan
Author: Yap Seng Chong
Author: Bee Wah Lee
Author: Lynette Pei-Chi Shek
Author: Fabian Kok Peng Yap
Author: Philip C Calder ORCID iD
Author: Keith M Godfrey ORCID iD
Author: Mary Foong-Fong Chong
Author: Evelyn Xiu Ling Loo
Corporate Author: et al.

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