The University of Southampton
University of Southampton Institutional Repository

Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model

Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model
Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model

There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.

Compartment model, Computational fluid dynamics, High-shear wet granulation, Population-balance model
1674-2001
Abrahamsson, P.J.
5c71c631-5be2-4c5e-bd33-d1666efe995f
Kvist, P.
22bad1e7-7186-4650-a568-11ee8ad1c852
Reynolds, G.
a15b46ea-24f4-452d-8ba4-d48624e3e3b2
Yu, Xi
7e4f553f-cc11-4c6e-ad6d-9fb5c3c07a60
Niklasson Björn, I.
fc714aae-6fd3-4b0b-86a3-de084f807694
Hounslow, M.J.
f883426e-2100-45c5-890b-3d6e8e3a6e68
Rasmuson, A.
5e590675-86e3-4327-a3a8-033d2e1877e0
Abrahamsson, P.J.
5c71c631-5be2-4c5e-bd33-d1666efe995f
Kvist, P.
22bad1e7-7186-4650-a568-11ee8ad1c852
Reynolds, G.
a15b46ea-24f4-452d-8ba4-d48624e3e3b2
Yu, Xi
7e4f553f-cc11-4c6e-ad6d-9fb5c3c07a60
Niklasson Björn, I.
fc714aae-6fd3-4b0b-86a3-de084f807694
Hounslow, M.J.
f883426e-2100-45c5-890b-3d6e8e3a6e68
Rasmuson, A.
5e590675-86e3-4327-a3a8-033d2e1877e0

Abrahamsson, P.J., Kvist, P., Reynolds, G., Yu, Xi, Niklasson Björn, I., Hounslow, M.J. and Rasmuson, A. (2017) Analysis of mesoscale effects in high-shear granulation through a computational fluid dynamics–population balance coupled compartment model. Particuology, 36. (doi:10.1016/j.partic.2017.01.008).

Record type: Article

Abstract

There is a need for mesoscale resolution and coupling between flow-field information and the evolution of particle properties in high-shear granulation. We have developed a modelling framework that compartmentalizes the high-shear granulation process based on relevant process parameters in time and space. The model comprises a coupled-flow-field and population-balance solver and is used to resolve and analyze the effects of mesoscales on the evolution of particle properties. A Diosna high-shear mixer was modelled with microcrystalline cellulose powder as the granulation material. An analysis of the flow-field solution and compartmentalization allows for a resolution of the stress and collision peak at the impeller blades. Different compartmentalizations showed the importance of resolving the impeller region, for aggregating systems and systems with breakage. An independent study investigated the time evolution of the flow field by changing the particle properties in three discrete steps that represent powder mixing, the initial granulation stage mixing and the late stage granular mixing. The results of the temporal resolution study show clear changes in collision behavior, especially from powder to granular mixing, which indicates the importance of resolving mesoscale phenomena in time and space.

Text
Anslysis of meso-scale effects in high shear granulation through a CFD-PBM coupled compartment model-accpeted version - Accepted Manuscript
Download (601kB)

More information

Accepted/In Press date: 10 January 2017
e-pub ahead of print date: 20 June 2017
Published date: 22 December 2017
Additional Information: Publisher Copyright: © 2017 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences
Keywords: Compartment model, Computational fluid dynamics, High-shear wet granulation, Population-balance model

Identifiers

Local EPrints ID: 482908
URI: http://eprints.soton.ac.uk/id/eprint/482908
ISSN: 1674-2001
PURE UUID: bdacf375-446c-41f0-8e8a-79b9017e67cd

Catalogue record

Date deposited: 17 Oct 2023 16:37
Last modified: 06 Jun 2024 02:19

Export record

Altmetrics

Contributors

Author: P.J. Abrahamsson
Author: P. Kvist
Author: G. Reynolds
Author: Xi Yu ORCID iD
Author: I. Niklasson Björn
Author: M.J. Hounslow
Author: A. Rasmuson

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×